Results 141 to 150 of about 18,911,738 (262)

Experimental demonstration of improved magnetorelaxometry imaging performance using optimized coil configurations. [PDF]

Med Phys, 2022
Schier P, Liebl M, Steinhoff U, Wiekhorst F, Baumgarten D.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Opto-Mechanical Integrated Analysis of Micro-Vibration Effects on the Imaging Performance of a Precision Optical System. [PDF]

Micromachines (Basel)
Liu R, Liang Z, Zhang Y, Li Q.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Novel Mixed Stimulation Pattern for Balanced Pulmonary EIT Imaging Performance. [PDF]

Bioengineering (Basel)
Zhao Z, Gao Z, Zhu H, Zhao Z, Dai M, Liu Z, Fu F, Yang L.   +7 more
europepmc   +1 more source

Analysis of the surface plasmon resonance interferometric imaging performance of scanning confocal surface plasmon microscopy. [PDF]

Biomed Opt Express, 2022
Tontarawongsa S, Visitsattapongse S, Pechprasarn S.   +2 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Assessing imaging performance of ultrasound systems using a random hypoechoic sphere phantom with freehand scanning. [PDF]

Med Phys
Yu B, Wu D, Baiu C, Lu ZF.
europepmc   +1 more source

Safety and imaging performance of two-channel RF shimming for fetal MRI at 3T. [PDF]

Magn Reson Med, 2021
Yetisir F, Abaci Turk E, Guerin B, Gagoski BA, Grant PE, Adalsteinsson E, Wald LL.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source