Results 161 to 170 of about 18,911,738 (262)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Design, fabrication, and optical imaging performance comparison of precision microlens arrays for application in plenoptic microscopy systems. [PDF]

Sci Rep
Kim C, Lee M.
europepmc   +1 more source

Inclusion of quasi-vertex views in a brain-dedicated multi-pinhole SPECT system for improved imaging performance. [PDF]

Phys Med Biol, 2021
Auer B, Zeraatkar N, Goding JC, Könik A, Fromme TJ, Kalluri KS, Furenlid LR, Kuo PH, King MA.   +8 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Variation in Prostate Magnetic Resonance Imaging Performance: Data from the Prostate Biopsy Collaborative Group. [PDF]

Eur Urol Oncol
Nalavenkata SB, Vertosick E, Briganti A, Ahmed H, Eldred-Evans D, Gordon S, Raghallaigh H, Gratzke C, O'Callaghan M, Liss M, Chiu P, Müntener M, Yaxley J, Poyet C, Jahnen M, Toi A, Ghai S, Margolis D, Ankerst D, Ehdaie B, Patel MI, Vickers AJ.   +21 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Theoretical Investigation of Photon Interaction and X-Ray Imaging Performance of PEEK-Based Composites for Medical Implants. [PDF]

Polymers (Basel)
Akhdar H.
europepmc   +1 more source

The Heating Efficiency and Imaging Performance of Magnesium Iron Oxide@tetramethyl Ammonium Hydroxide Nanoparticles for Biomedical Applications. [PDF]

Nanomaterials (Basel), 2021
Darwish MSA, Kim H, Bui MP, Le TA, Lee H, Ryu C, Lee JY, Yoon J.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Development of a portable testing chamber to assess imaging performance of laparoscopes in low- and middle-income countries. [PDF]

J Biomed Opt
Barnes AC, Kaluzienski M, Quang T, Chen J, Singh S, Smith W, Simcox T, Kworekwa P, Nansubuga RK, Ssekitoleko R, Fitzgerald TN, Mueller JL.   +11 more
europepmc   +1 more source