Results 131 to 140 of about 6,084,382 (354)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

UWB device for breast microwave imaging: phantom and clinical validations

Measurement, 2019
Alessandro Vispa, Lorenzo Sani, Martina Paoli, Alessandra Bigotti, Giovanni Raspa, N. Ghavami, S. Caschera, M. Ghavami, Michele Duranti, G. Tiberi   +9 more
semanticscholar   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

An international phantom study of inter-site variability in Technetium-99m image quantification: analyses from the TARGET radioembolization study

EJNMMI Physics
Background Personalised multi-compartment dosimetry based on [99mTc]Tc-MAA is a valuable tool for planning 90Y radioembolization treatments. The establishment and effective application of dose–effect relationships in yttrium-90 (90Y) radioembolization ...
Grace Keane, Rob van Rooij, Marnix Lam, S. Cheenu Kappadath, Bilal Kovan, Stephanie Leon, Matthew Dreher, Kirk Fowers, Hugo de Jong   +8 more
doaj   +1 more source

FUNDAMENTAL STUDY OF CEREBRAL BLOOD FLOW IMAGING WITH SINGLE-PHOTON-EMISSION COMPUTED TOMOGRAPHY. : COMPARISON AMONG PHANTOM IMAGES USING ^<123>I PRODUCED BY THE (p, 2n) OR (p, 5n) REACTION AND ^<99m>Tc NUCLIDE

, 1987
Shinichi Yanagimoto, T Tomomitsu, Hiroaki Mimura, Naomasa Narihiro, Koushi Ishii, Hiroo Hiji   +5 more
openalex   +2 more sources

Three-Dimensional Image Registration of Phantom Vertebrae for Image-Guided Surgery: A Preliminary Study [PDF]

, 2002
Diane M. Muratore, Jeannette Herring Russ, Benoît M. Dawant, Robert L. Galloway   +3 more
openalex   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Assessment of ultrasound image quality in a reference phantom using gel and liquid standoff pads

WFUMB Ultrasound Open
Background: and Methods: This paper presents a review of image quality in ultrasound imaging when using gel and liquid standoff pads, compared to imaging without a standoff pad. Imaging metrics assessed are lateral resolution, nearfield target intensity,
Catherine Paverd, Alexander Martin, Marga Rominger, Lisa Ruby   +3 more
doaj