Results 161 to 170 of about 1,882,249 (253)

Preliminary Results: Large Bore Clinical MPI System Imaging Human Head-sized FOVs

Clinical-scale MPI development has, so far, typically been optimized toward specific body parts and/or clinical applications, including functional brain imaging[1], perfusion[2], interventional[3], and cardiac imaging[4].
Mattingly, Eli, Trease, David, Fields, Kyle, Konkle, Justin J, Goodwill, Patrick W, Chandeeing, Mike, Truxal, Ashley, Weyhmiller, Marcela, Davison, Bryanna, Greve, Joan, Barcikowski, Elliott, Fetsch, Walter, Mason, Erica E, Fellows, Benjamin, Sehl, Olivia, Sanders, Toby, Carl, John   +16 more
core   +1 more source

Phantoms for use in optical coherence elastography. [PDF]

J Biomed Opt
Navaeipour F, Li J, Zamani S, Kranold L, Sanderson RW, Kennedy BF.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

In-silico investigation into optimal photoacoustic probe design using a digital thyroid phantom. [PDF]

J Biomed Opt
Rietberg MT, Veltman J, Wolterink JM, Manohar S.   +3 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Enhancing skin tone representation in optical vascular phantoms. [PDF]

J Biomed Opt
Ranta-Lassila A, Rannaste L, Petäjä J, Korkalainen M, Alamäki M, Popov A.   +5 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Use of a Retinal Phantom to Facilitate Adaptive Optics Scanning Light Ophthalmoscopy Imaging in a Multicenter Clinical Trial. [PDF]

Transl Vis Sci Technol
Kreis J, Wong J, Yang Y, Bharadwaj P, Cooper RF, Gaffney M, Govindasamy N, Green AL, Higgins BP, Jiang YY, Kalitzeos A, Michaelides M, Morgan JIW, Porter J, Rogers JD, Rosenthal I, Sabesan R, Sapoznik KA, Schill AW, Sochol RD, Wang Y, Warner RL, Warr E, Wendel BJ, Wynne N, Xu P, Tarima S, Hammer DX, Agrawal A, Duncan JL, Carroll J.   +30 more
europepmc   +1 more source