MMBM-Driven and IMU-Assisted Adaptive Deblurring for Periodic Rotational-Scanning Panoramic Imaging Systems. [PDF]
Sensors (Basel)Wang Y +5 more
europepmc +1 more source
Technologies for depth scanning in miniature optical imaging systems [Invited]. [PDF]
Biomed Opt Express, 2023 Liu Y, Zhang H, Li X.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Photoacoustic imaging of micro-calcifications
, 2014 [[abstract]]Breast microcalcifications are one of the important indicators for early breast cancer detection. Currently, X-ray mammography and ultrasound imaging are routine diagnostic tools in clinics for breast cancer; however, X-ray mammography is ...
M.-L. Li;T.-C. Hsiao;P.-H. Wang;Y.-Y. Cheng;C.-T. Fan
core
Dual-Wavelength Metalens Design for Compact LWIR and MWIR Imaging Systems. [PDF]
Sensors (Basel)Liu T +6 more
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Influence of ocular biometry on peripheral retinal visualization: a comparative study of Clarus and Optos widefield imaging systems. [PDF]
BMC OphthalmolSpartalis C, Fisus A, Ruiss M, Findl O.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Challenges in visualizing endogenous <i>loci</i> in the human genome using CRISPR-based imaging systems. [PDF]
BioTechnologia (Pozn)Nowaczyk M +3 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source