Results 161 to 170 of about 11,587,356 (306)

Comparative Evaluation of Field of View Across Widefield Retinal Imaging Systems. [PDF]

Transl Vis Sci Technol
Ni S, Ng R, Bayhaqi Y, Sutter D, Ostmo S, Huang D, Young BK, Campbell JP, Jian Y.   +8 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

High magnification optical imaging systems for the characterization of soft X-ray focii. [PDF]

J Synchrotron Radiat
Al Haddad A, Sarracini A, Schnorr K, Knopp G, Krempasky J, Arrell C, Augustin S, Bassement L, Brupbacher K, Vila-Comamala J, David C, Flechsig U, Follath R, Guo Z, Herzog M, Knurr J, Lombosi C, Manetti E, Mandal S, Morillo-Candas AS, Qi P, Sorokin BV, Stubbs S, Sun Z, Tiefenbacher SC, Vonka J, Wagner UH, Xie X, Yang N, Zhang H, Bostedt C.   +30 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Radiographic Imaging System [PDF]

Science, 1973
openaire   +2 more sources

Microwave head imaging systems for early brain tumor detection: antenna designs and emerging substrates. [PDF]

MethodsX
Mathew J, Khalaf OI, George NM, Michel A, Abraham NE, Alsekait DM, Alzu'bi S, AbdElminaam DS.   +7 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Concordance of AI-Assisted and Hybrid AI-Assisted Cervical Imaging Systems with Visual Inspection with Acetic Acid for Cervical Precancer Screening in West Bandung, Indonesia. [PDF]

Int J Womens Health
Mantilidewi KI, Zenyda RRS, Alhayat MRVA, Wardhana RMW, Adzkia Q, Nabiylah NA, Zahran MGS, Mukhayadi H, Suardi D, Agustian D, Hidayat YM.   +10 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source