The efficacy of generic imatinib in patients with chronic myeloid leukemia: A single centre experience [PDF]
Vojnosanitetski Pregled, 2021 Background/Aim. The treatment of chronic myeloid leukemia (CML) has changed dramatically with the advent of targeted therapies. This study aimed to assess the efficacy of generic imatinib in CML patients treated in our center. Methods.
Urošević Ivana +9 more
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Induction of autophagy has protective roles in imatinib-induced cardiotoxicity
Toxicology Reports, 2021 Cardiotoxicity is one of the severe adverse effects of chemotherapeutic agents. Imatinib was previously reported to induce cardiotoxicity. Autophagy is an intracellular bulk protein and organelle degradation process, but its roles in cardiac diseases are
Miyuki Kobara +3 more
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The Oncologist, 2007 Learning Objectives After completing this course, the reader will be able to: Identify the current indications for imatinib.Describe the pharmacokinetics of imatinib.Discuss the mechanisms involved in imatinib resistance. Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist ...
Christine E, de Kogel +1 more
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Case Reports in Oncology, 2021 Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse drug reaction; reported cases are sometimes imatinib mesylate induced.
Hyerin Park, Gil-Soon Choi, Eun Mi Lee
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Antitumor effect of the tyrosine kinase inhibitor nilotinib on gastrointestinal stromal tumor (GIST) and imatinib-resistant GIST cells. [PDF]
PLoS ONE, 2014 Despite the benefits of imatinib for treating gastrointestinal stromal tumors (GIST), the prognosis for high risk GIST and imatinib-resistant (IR) GIST remains poor. The mechanisms of imatinib resistance have not yet been fully clarified.
Hiroyuki Sako +9 more
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Inhibition of c-Kit is not required for reversal of hyperglycemia by imatinib in NOD mice. [PDF]
PLoS ONE, 2014 Recent studies indicate that tyrosine kinase inhibitors, including imatinib, can reverse hyperglycemia in non-obese diabetic (NOD) mice, a model of type 1 diabetes (T1D). Imatinib inhibits c-Abl, c-Kit, and PDGFRs.
Janet Lau +5 more
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Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes [PDF]
, 2020 Integration of microfluidics and biosensing functionalities on a single device holds promise in continuous health monitoring and disease diagnosis for point-of-care applications.
Dodd, Linzi +10 more
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Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity. [PDF]
PLoS Pathogens, 2015 Imatinib mesylate (Gleevec) inhibits Abl1, c-Kit, and related protein tyrosine kinases (PTKs) and serves as a therapeutic for chronic myelogenous leukemia and gastrointestinal stromal tumors.
Ruth J Napier +16 more
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Frontiers in Systems Neuroscience, 2022 Lamina propria interstitial cells that express the tyrosine kinase receptor, platelet-derived growth factor receptor alpha (PDGFRα) may play a role in urinary sensory signaling.
Megan E. Perkins +3 more
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Is Imatinib Maintenance Required for Patients with Relapse Chronic Myeloid Leukemia Post-Transplantation Obtaining CMR? A Pilot Retrospective Investigation. [PDF]
PLoS ONE, 2013 Imatinib can induce complete molecular remission (CMR) in relapse chronic myelogenous leukemia (CML) after allogeneic hematopoietic stem cell transplantation, but it is indefinite whether imatinib is required to maintain CMR.
Hua Jin +11 more
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