Results 11 to 20 of about 72,525 (247)
Analysis of imatinib in bone marrow and plasma samples of chronic myeloid leukaemia patients using solid phase extraction LC-ESI-MS [PDF]
, 2011 The LC-ESI-MS was developed and validated for the analysis of imatinib in plasma and bone marrow samples using deuterated imatinib (D(8)-IM) as an internal standard. The biological samples were extracted using Strata-X-C SPE cartridges and separated on C(
Iqbal, Zafar +4 more
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Antitumor effect of the tyrosine kinase inhibitor nilotinib on gastrointestinal stromal tumor (GIST) and imatinib-resistant GIST cells. [PDF]
PLoS ONE, 2014 Despite the benefits of imatinib for treating gastrointestinal stromal tumors (GIST), the prognosis for high risk GIST and imatinib-resistant (IR) GIST remains poor. The mechanisms of imatinib resistance have not yet been fully clarified.
Hiroyuki Sako +9 more
doaj +2 more sources
The efficacy of generic imatinib in patients with chronic myeloid leukemia: A single centre experience [PDF]
Vojnosanitetski Pregled, 2021 Background/Aim. The treatment of chronic myeloid leukemia (CML) has changed dramatically with the advent of targeted therapies. This study aimed to assess the efficacy of generic imatinib in CML patients treated in our center. Methods.
Urošević Ivana +9 more
doaj +1 more source
Imatinib in the treatment of chronic myeloid leukemia: current perspectives on optimal dose
Blood and Lymphatic Cancer: Targets and Therapy, 2015 Joanna Waclaw,1 Tomasz Sacha,1 Tomasz Stoklosa,21Department of Hematology, Jagiellonian University Collegium Medicum, Kraków, 2Department of Immunology, Medical University of Warsaw, Warsaw, Poland Abstract: Imatinib was the first tyrosine kinase
Waclaw J, Sacha T, Stoklosa T
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Induction of autophagy has protective roles in imatinib-induced cardiotoxicity
Toxicology Reports, 2021 Cardiotoxicity is one of the severe adverse effects of chemotherapeutic agents. Imatinib was previously reported to induce cardiotoxicity. Autophagy is an intracellular bulk protein and organelle degradation process, but its roles in cardiac diseases are
Miyuki Kobara +3 more
doaj +1 more source
The Oncologist, 2007 Learning Objectives After completing this course, the reader will be able to: Identify the current indications for imatinib.Describe the pharmacokinetics of imatinib.Discuss the mechanisms involved in imatinib resistance. Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist ...
Christine E, de Kogel +1 more
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Case Reports in Oncology, 2021 Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse drug reaction; reported cases are sometimes imatinib mesylate induced.
Hyerin Park, Gil-Soon Choi, Eun Mi Lee
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Inhibition of c-Kit is not required for reversal of hyperglycemia by imatinib in NOD mice. [PDF]
PLoS ONE, 2014 Recent studies indicate that tyrosine kinase inhibitors, including imatinib, can reverse hyperglycemia in non-obese diabetic (NOD) mice, a model of type 1 diabetes (T1D). Imatinib inhibits c-Abl, c-Kit, and PDGFRs.
Janet Lau +5 more
doaj +1 more source
Dasatinib in the treatment of imatinib refractory chronic myeloid leukemia
Biologics: Targets & Therapy, 2009 Radhakrishnan Ramchandren, Charles A SchifferDivision of Hematology/Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USAAbstract: The development of imatinib for the treatment of chronic myeloid leukemia (CML ...
Radhakrishnan Ramchandren +1 more
doaj +1 more source
Frontiers in Systems Neuroscience, 2022 Lamina propria interstitial cells that express the tyrosine kinase receptor, platelet-derived growth factor receptor alpha (PDGFRα) may play a role in urinary sensory signaling.
Megan E. Perkins +3 more
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