Results 91 to 100 of about 87,925 (315)

Promotion of Autophagy and Apoptosis in Colorectal Cancer Exposed to Imatinib and Thymoquinone. [PDF]

J Biochem Mol Toxicol
The combination of IM and TQ induced autophagy in HCT116 cell line which in turn enhanced apoptosis. The combination inhibited colonies formation as well as the increments of various apoptotic markers. AMPK, when senses the rising autophagy, it will always activate apoptosis in a stress‐defense response.
El-Khouly D, Thabet NA, Sayed-Ahmed M, Omran MM.   +3 more
europepmc   +2 more sources

Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia.

New England Journal of Medicine, 2003
BACKGROUND In a randomized trial, 1106 patients with chronic myeloid leukemia (CML) in chronic phase were assigned to imatinib or interferon alfa plus cytarabine as initial therapy.
T. Hughes, J. Kaeda, S. Branford, Z. Rudzki, A. Hochhaus, M. Hensley, I. Gathmann, A. Bolton, Iris van Hoomissen, J. Goldman, J. Radich   +10 more
semanticscholar   +1 more source

Recent Green and Sustainable Pd‐Catalyzed Aminations

ChemSusChem, Accepted Article.
Pd‐catalyzed aminations, while a powerful and commonly employed method of C‐N bond construction, often relies on unsustainable technologies that utilize: egregious organic solvents, high temperatures, long reaction times, and high catalyst loadings, especially of palladium.
John M Saunders, kylee Dismuke Rodriguez, Robert Lammert, Jordan Yirak, Karthik S Iyer, Bruce Howard Lipshutz, Madison J Wong   +6 more
wiley   +1 more source

Safety, tolerability, and pharmacokinetics of single and multiple topical ophthalmic administration of imatinib mesylate in healthy subjects

Clinical and Translational Science, 2022
For the long‐term efficacy of dry eye disease treatment, relieving underlying inflammation is necessary. Imatinib mesylate is a novel ophthalmic formulation of imatinib mesylate, which is expected to alleviate inflammation by inhibiting the discoidin ...
Joo Young Na, Ki Young Huh, Kyung‐Sang Yu, Joon Young Hyon, Hye Cheong Koo, Jong Ho Lee, Ji Chang You, Jae‐Yong Chung   +7 more
doaj   +1 more source

Natural killer-cell counts are associated with molecular relapse-free survival after imatinib discontinuation in chronic myeloid leukemia: the IMMUNOSTIM study

Haematologica, 2017
Despite persistence of leukemic stem cells, patients with chronic myeloid leukemia who achieve and maintain deep molecular responses may successfully stop the tyrosine kinase inhibitor imatinib.
D. Réa, Guylaine Henry, Zena Khaznadar, G. Étienne, F. Guilhot, F. Nicolini, J. Guilhot, P. Rousselot, F. Huguet, L. Legros, M. Gardembas, V. Dubruille, A. Guerci-Bresler, A. Charbonnier, F. Maloisel, J. Ianotto, B. Villemagne, F. Mahon, H. Moins‐Teisserenc, N. Dulphy, A. Toubert   +20 more
semanticscholar   +1 more source

Erratum to: Exploiting the promiscuity of imatinib [PDF]

BMC Biology, 2010
An error in the PDB code occurred in the article published in the Journal of Biology [1]. In the legend to Figure One, instead of 1FW3, the correct PDB code is 3FW1.
Lee, Shun J, Wang, Jean YJ
openaire   +4 more sources

A Comprehensive Review on Capillary Electrophoresis–Mass Spectrometry in Advancing Biomolecular Research

ELECTROPHORESIS, EarlyView.
ABSTRACT This review provides an in‐depth exploration of capillary electrophoresis–mass spectrometry (CE–MS) in biomolecular research from 2020 to 2024. CE–MS emerges as a versatile and powerful tool due to its numerous advantages, facilitating the analysis of various biomolecules, including proteins, peptides, oligonucleotides, and other metabolites ...
Laura Pont, María Vergara‐Barberán, Enrique Javier Carrasco‐Correa   +2 more
wiley   +1 more source

Proteome Changes Induced by Imatinib and Novel Imatinib Derivatives in K562 Human Chronic Myeloid Leukemia Cells

Proteomes, 2014
Imatinib mesylate is the leading compound to treat chronic myeloid leukemia (CML) and other cancers, through its inhibition of Bcr-Abl tyrosine kinases.
Katerina Arvaniti, Anastasia Papadioti, Maria Kinigopoulou, Vassiliki Theodorou, Konstantinos Skobridis, Georgios Tsiotis   +5 more
doaj   +1 more source

Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro. [PDF]

PLoS ONE, 2011
Imatinib Mesylate (Gleevec) is a drug that potently counteracts diabetes both in humans and in animal models for human diabetes. We have previously reported that this compound in human pancreatic islets stimulates NF-κB signaling and islet cell survival.
Dariush Mokhtari, Tingting Li, Tao Lu, Nils Welsh   +3 more
doaj   +1 more source

A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies

Exploration, EarlyView.
The monkeypox virus (MPXV) has spread to many countries and caused thousands of infections all over the world. This review comprehensively introduces the biology, epidemiological characteristics of MPXV, and clinical manifestations of Mpox. The approaches for diagnosis, treatment, and prevention are also introduced, aiming to improve the general ...
Lin Jiang, Ailan Xu, Lin Guan, Yong Tang, Guangshuai Chai, Junya Feng, Yueqi Wu, Maochen Li, Chuxie Zhang, Xiaojing Liu, Xiaolong Xu, Qingquan Liu, Lihua Song, Yigang Tong, Renald Blundell, Huahao Fan   +15 more
wiley   +1 more source