Results 111 to 120 of about 72,525 (247)
European Journal of Haematology, EarlyView.ABSTRACT Objectives Genetic rare diseases (GRDs), including chronic granulomatous disease, familial hemophagocytic lymphohistiocytosis, and congenital neutropenia, often require hematopoietic stem cell transplantation (HSCT) as the only curative option.
Bo Kyung Kim +6 more
wiley +1 more source
İmatinib: Mechanisms of Action and Mechanisms of Resistance Development
, 2012 İmatinib is a specific drug which was developed for the treatment of chronic myelogenous leukemia (KML) and is the pioneer drug in this area. İmatinib mesylate (Glivec) is a derivative of 2-phenylaminopyrimidine.
M. Merve Tuğlu, Mehmet Melli
core +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley +1 more source
Post‐Hoc Long‐Read Sequencing Links Leukemic Mutation Status to Single‐Cell Transcriptomes
European Journal of Haematology, EarlyView.ABSTRACT Single‐cell RNA‐sequencing‐based characterization of cells that belong to the neoplastic clone is a major challenge in hematologic neoplasms, where malignant and normal cells coexist. Confident molecular profiling requires simultaneous analysis of gene expression and genetic mutations in individual cells, an ability that is not supported by ...
Sofia Papavasileiou +8 more
wiley +1 more source
Clinical pharmacokinetics of imatinib and its therapeutic relevance
, 2013 The pharmacokinetic profile of imatinib has been assessed in healthy subjects and in population studies among thousands of patients with CML or GIST. Imatinib is rapidly and extensively absorbed from the GI tract, reaching a peak plasma concentration ...
Csajka, C. +9 more
core +1 more source
Imatinib treatment for idiopathic pulmonary fibrosis: Randomized placebo-controlled trial results
, 2010 Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with no known efficacious therapy. Imatinib is a tyrosine kinase inhibitor with potential efficacy to treat fibrotic lung disease.
Daniels, Craig E +6 more
core +1 more source
HIV Medicine, EarlyView.Abstract Background Data on chemotherapeutic efficacy and tolerability for Kaposi Sarcomas (KS) in people living with HIV (PWH) and HIV‐virological control are limited. We aimed to describe clinical responses and tolerability of KS therapies in PWH with HIV‐aviraemic KS in a prospective cohort.
S. Bacquart +10 more
wiley +1 more source
Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate [PDF]
, 2007 The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML).
Wei, Yuan
core +1 more source
Pulmonary CirculationPulmonary tumor thrombotic microangiopathy (PTTM) is a severe and fatal disease that rapidly causes pulmonary hypertension (PH). While imatinib shows potential for treating PH related to PTTM, it remains unclear if imatinib should continue or be ...
Atsumasa Kurozumi +10 more
doaj +1 more source