Results 91 to 100 of about 101,700 (245)

Targeting RTK signaling pathways in cancer [PDF]

, 2015
The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding.
Regad, T
core   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Whole‐transcriptome sequencing analyses identified exosomal circular RNAs in the plasma of pancreatic cancer patients as novel blood‐based biomarkers of disease

VIEW, EarlyView.
Pancreatic cancer (PaCa) has a poor prognosis, with low resection rates and high relapse rates, highlighting the urgent need for novel diagnostic biomarkers. Here, we performed whole‐transcriptome sequencing of plasma‐derived exosomes from PaCa patients and identified several differentially expressed circular RNAs (circRNAs).
Xiaomeng He, Yang Di, Lixiang Sun, Zhirong Wu, Mengting Luo, Xin Zhang, Huaqin Sun, Wanli Xu, Wenchuan Wu, Boheng Zhang, Jin Wang   +10 more
wiley   +1 more source

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I [PDF]

, 2012
Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase activity.
Badura, Susanne, Khateb, Mamduh, Mahajna, Jamal, Metodieva, Anna, Mian, Afsar Ali, Najajreh, Yousef, Ottmann, Oliver Gerhard, Ruimi, Nili, Ruthardt, Martin   +8 more
core   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. [PDF]

, 2011
Tyrosine kinase inhibitors (TKIs) are widely used to treat patients with leukaemia driven by BCR-ABL1 (ref. 1) and other oncogenic tyrosine kinases. Recent efforts have focused on developing more potent TKIs that also inhibit mutant tyrosine kinases ...
Braig, Melanie, Cerchietti, Leandro, Duy, Cihangir, Geng, Huimin, Graeber, Thomas G, Heisterkamp, Nora, Herzog, Sebastian, Hofmann, Wolf-Karsten, Hurtz, Christian, Jumaa, Hassan, Kim, Yong-mi, Klemm, Lars, Koeffler, H Phillip, Kweon, Soo-mi, Melnick, Ari, Müschen, Markus, Nahar, Rahul, Park, Eugene, Shojaee, Seyedmehdi, Swaminathan, Srividya, Wu, Hong, Ye, B Hilda, Yu, J Jessica   +22 more
core  

Model for tumour growth with treatment by continuous and pulsed chemotherapy [PDF]

, 2013
Peer ...
A.M. Batista, Ahn, Anderson, Balduzzi, Banerjee, Baptista, Baserga, Becker, Brú, C. Grebogi, De Pillis, De Pillis, F.S. Borges, H.P. Ren, Iarosz, K.C. Iarosz, Kuebler, Kuznetsov, Liu, M.S. Baptista, Matta, Michor, Pinho, R.L. Viana, S.R. Lopes, Sarkar, Shulman, Siu, Villasana, Wodarz   +29 more
core   +2 more sources

Potential targets for renal cell carcinoma therapy: Mechanistic research and prospects of CAFs in renal cell carcinoma

VIEW, EarlyView.
Cancer‐associated fibroblasts exert intricate mechanisms in the progression and metastasis of renal cell carcinoma. Existing studies have validated the relevant mechanisms of three signaling pathways, which hold promising potential as novel therapeutic targets.
Ruiqiang Sun, Jiankun Zhang, Meixi Liu, Xiyue Dong, Yuanshan Cui   +4 more
wiley   +1 more source

Imatinib and its combination with 2,5-dimethyl-celecoxibinduces apoptosis of human HT-29 colorectal cancer cells

Research in Pharmaceutical Sciences, 2017
Mono-targeting by imatinib as a main antitumor agent does not always accomplish complete cancer suppression. 2,5-dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor, celecoxib, that lacks COX-2 ...
Somayeh Atari-Hajipirloo, Saba Nikanfar, Amir Heydari, Fatemeh Kheradmand   +3 more
doaj   +1 more source

Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series) [PDF]

, 2016
The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH).
Awad, Keytam S., de Jesus Perez, Vinicio, MacLean, Margaret, West, James D.   +3 more
core   +1 more source