Results 121 to 130 of about 74,341 (223)
ABSTRACT Objectives Genetic rare diseases (GRDs), including chronic granulomatous disease, familial hemophagocytic lymphohistiocytosis, and congenital neutropenia, often require hematopoietic stem cell transplantation (HSCT) as the only curative option.
Bo Kyung Kim +6 more
wiley +1 more source
Peritoneal Tuberculosis and Chronic Myeloid Leukaemia: A Case of Hickam's Dictum
ABSTRACT We report the case of a 34‐year‐old male with persistent fever, ascites, thrombocytosis and clinical deterioration despite broad‐spectrum therapy who was ultimately diagnosed with peritoneal tuberculosis and concurrent chronic myeloid leukaemia.
Zayn Al‐Timimi +3 more
wiley +1 more source
Control of Gemcitabine Activity With Blue and Red Light
Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten +6 more
wiley +1 more source
Force profiles of imatinib dissociation from imatinib-Abl complex.
(A) Force profile of imatinib unbinding along ATP-channel. (B) Force profile of imatinib unbinding along allosteric-pocket-channel. (C) Averaged force profiles of imatinib unbinding along ATP-channel (red) and allosteric-pocket-channel (black).
Jun Zou (683) +5 more
core +1 more source
Clinical pharmacokinetics of imatinib and its therapeutic relevance
The pharmacokinetic profile of imatinib has been assessed in healthy subjects and in population studies among thousands of patients with CML or GIST. Imatinib is rapidly and extensively absorbed from the GI tract, reaching a peak plasma concentration ...
Csajka, C. +9 more
core
F Duffaud, S Salas, T Huyn, JL DevilleLa Timone University Hospital, Marseille, FranceAbstract: Mutations of the KIT gene are the molecular hallmark of most gastrointestinal stromal tumors (GISTs).
F Duffaud, T Huyn, et al, S Salas
core
The effects of saquinavir on imatinib-resistant chronic myelogenous leukemia cell lines
We evaluated the effect of the human immunodeficiency virus (HIV) protease inhibitor saquinavir on the imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia cell lines.
F Timeus +6 more
doaj
Imatinib mesylate is highly effective in relapsed chronic myelogenous leukemia (CML) after allogeneic hematopoetic stem cell transplantation (HSCT). However, it is unknown whether imatinib produces durable molecular remissions.
M Weisser +5 more
doaj

