Results 161 to 170 of about 117,898 (292)

Supplementary Methods from Imatinib Sensitivity in BCR-ABL1–Positive Chronic Myeloid Leukemia Cells Is Regulated by the Remaining Normal <i>ABL1</i> Allele

, 2023
Annarosa Virgili, Mateusz Koptyra, Yashodhara Dasgupta, Eliza Głodkowska‐Mrówka, Tomasz Stokłosa, Elisabeth P. Nacheva, Tomasz Skórski   +6 more
openalex   +1 more source

A Proteomics Resource Investigating Fibrosis: Proof‐of‐Concept for Identifying Novel Drug Candidates

PROTEOMICS, Volume 26, Issue 1, Page 94-99, January 2026.
ABSTRACT Fibrosis is characterised by inappropriate wound healing and the buildup of excessive fibrous connective tissue, in particular within the extracellular matrix (ECM). This can occur in multiple organs, ultimately leading to organ failure. Despite the high burden of fibrosis, treatment options only delay disease progression.
Hanne Devos, Manousos Makridakis, Rafael Stroggilos, Mayra Alejandra Jaimes Campos, Aggeliki Tserga, Marika Mokou, Maria G. Roubelakis, Jerome Zoidakis, Antonia Vlahou, Agnieszka Latosinska   +9 more
wiley   +1 more source

Dasatinib in the treatment of imatinib refractory chronic myeloid leukemia

Biologics: Targets & Therapy, 2009
Radhakrishnan Ramchandren, Charles A SchifferDivision of Hematology/Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USAAbstract: The development of imatinib for the treatment of chronic myeloid leukemia (CML ...
Radhakrishnan Ramchandren, Charles A Schiffer   +1 more
doaj  

Supplemental Figure 1 from Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor

, 2023
Phillip Zook, Harsh B. Pathak, Martin G. Belinsky, Lawrence Gersz, Karthik Devarajan, Yan Zhou, Andrew K. Godwin, Margaret von Mehren, Lori Rink   +8 more
openalex   +1 more source

Physiologically‐Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT A physiologically‐based pharmacokinetic (PBPK) model of niraparib and its primary metabolite using a relevant virtual cancer population is reported here. A series of in vitro experiments using liver S9, microsomes, and hepatocytes with various inhibitors and recombinant supersomes demonstrated that niraparib is specifically metabolized by ...
Gareth J. Lewis, Roxanne C. Jewell, Anu Shilpa Krishnatry, Kunal S. Taskar   +3 more
wiley   +1 more source

Pharmaceutical inhibition of BCL6 ameliorates resistance to imatinib in chronic myeloid leukemia [PDF]

Yingying Xiao, Fang Deng, Yun Luo, Teng Wang   +3 more
openalex   +1 more source

Genomic Subtypes of GISTs for Stratifying Patient Response to Sunitinib following Imatinib Resistance: A Pooled Analysis and Systematic Review [PDF]

, 2018
Siyuan Tan, Ping Chen, Jiafu Ji, Shanshan Guo, Dapeng Yu, Tetsuya Asakawa, Yu Zhou, Masanobu Abe, Liang Zong   +8 more
openalex   +1 more source

Supplementary Figure S5 from Dual Inhibition of Bcr-Abl and Hsp90 by C086 Potently Inhibits the Proliferation of Imatinib-Resistant CML Cells

, 2023
Lixian Wu, Jing Yu, Ruijia Chen, Yang Liu, Liguang Lou, Ying Wu, Lisen Huang, Yingjuan Fan, Pinzhang Gao, Meijuan Huang, Yong Wu, Yuanzhong Chen, Jianhua Xu   +12 more
openalex   +1 more source

From Hypoglycaemia to Haemorrhage: A Case of Giant Pleural Solitary Fibrous Tumour With Doege–Potter Syndrome

Respirology Case Reports, Volume 14, Issue 1, January 2026.
We describe a case of Doege–Potter syndrome from a giant pleural solitary fibrous tumour in a 76‐year‐old male. This case highlights the potential for maintaining pre‐operative normoglycaemia without glucocorticoids and emphasises recognising tumour vascularity on imaging to anticipate intra‐operative bleeding risk. ABSTRACT Doege–Potter Syndrome (DPS)
Michael Xie, Ronan O'Donnabhain, Zemin Cao, Jazmin Eckhaus, Phillip Parente, Alan Wong, David Holcdorf, Victor Duong   +7 more
wiley   +1 more source

Data from Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation

, 2023
Xianping Shi, Xin Chen, Xiaofen Li, Xiaoying Lan, Chong Zhao, Shouting Liu, Hongbiao Huang, Ningning Liu, Siyan Liao, Wenbin Song, Ping Zhou, Shunqing Wang, Xu Li, Xuejun Wang, Q. Ping Dou, Jinbao Liu   +15 more
openalex   +1 more source