Results 71 to 80 of about 64,427 (282)
ABSTRACT The chronic nature of chronic myeloid leukemia (CML) has a negative impact on patients’ health‐related quality of life (HRQOL) and the need for prolonged oral tyrosine kinase inhibitors (TKIs) poses a risk to low or nonadherence over time. This systematic review seeks to analyze HRQOL outcomes and adherence to TKIs among pediatric, adolescent,
Rachel S. Werk+2 more
wiley +1 more source
Nanotechnology in Hematology: Enhancing Therapeutic Efficacy With Nanoparticles
ABSTRACT Background and Aims Hematological malignancies, such as leukemia, lymphoma, and multiple myeloma, contribute significantly to global cancer diagnoses. Despite progress in conventional therapies, such as chemotherapy and immunotherapy, these treatments face limitations, including nonspecific targeting, side effects, and drug resistance. The aim
Nima Torabi Fard+3 more
wiley +1 more source
Imatinib Mesylate-Induced Hyperpigmentation of the Nose and Palate
Dear Editor: Imatinib mesylate, a tyrosine kinase inhibitor targeting c-kit and platelet-derived growth factor, has been used for the treatment of hematologic malignancies.
Hyo Sang Song, H. Kang
semanticscholar +1 more source
Imatinib resistance: diagnostic and therapeutic choices
We report a case of a 42-year-old woman with t(9;22) positive chronic myeloid leukemia (CML) who developed a sub-optimal response to therapy with imatinib mesylate due to M351T mutation and low plasma level of imatinib. Dose increase of imatinib resulted
Marianna De Muro+3 more
doaj +1 more source
Gastrointestinal stromal tumor (GIST) of the Treitz’s angle– a very rare cause of high bowel obstruction [PDF]
Gastrointestinal stromal tumors (GIST) are somewhat rare gastrointestinal tumors - approximately 1% to 3% incidence, but they are the most common mesenchymal neoplasms of the gastrointestinal tract.
Georgescu, Lota Corina+3 more
core +3 more sources
ABSTRACT Background Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue malignancy with aggressive growth. Objective To summarize the surgical treatment and results of DFSP based on a case series and literature review. Methods Seventeen DFSP cases were analyzed retrospectively at our hospital from June 2016 to December 2022, including 14 males
Bing‐Jie Zhou+6 more
wiley +1 more source
A unique case of a 50-year-old Japanese male with jejunal leiomyosarcoma (LMS) who subsequently developed gastrointestinal stromal tumor (GIST) and desmoid tumor (DT) during five years and six months after the initial surgery is reported. The patient was
Yuji Kurihara+2 more
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Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap+10 more
wiley +1 more source
The monkeypox virus (MPXV) has spread to many countries and caused thousands of infections all over the world. This review comprehensively introduces the biology, epidemiological characteristics of MPXV, and clinical manifestations of Mpox. The approaches for diagnosis, treatment, and prevention are also introduced, aiming to improve the general ...
Lin Jiang+15 more
wiley +1 more source
Effect of astaxanthin in imatinib mesylate-induced cardiotoxicity
Aim: Imatinib mesylate is a tyrosine kinase inhibitor and is approved as a standard first-line therapy of chronic myeloid leukemia. Oxidative stress, as well as intracellular calcium overload and mitochondrial dysfunction, play an important role in ...
İshak Suat Övey, Can Ramazan Öncel
doaj