Results 71 to 80 of about 103,585 (306)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
On Improving the Classification of Imbalanced Data
Cybernetics and Information Technologies, 2017 Mining of imbalanced data isachallenging task due to its complex inherent characteristics. The conventional classifiers such as the nearest neighbor severely bias towards the majority class, as minority class data are under-represented and outnumbered ...
Mathews Lincy Meera, Seetha Hari
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Recapitulation of Imbalanced Data
International Journal of Innovative Technology and Exploring Engineering, 2020 In today’s authentic universe almost all applications are imbalanced. Data imbalance is growing faster than ever before as many systems are interested in extracting knowledge from lake of data. Imbalance issue occurs because required data is very rare and using that rare data if classification is done we may lead to inaccurate result.
Shaheen Layaq*, Dr. B. Manjula
openaire +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Connection Science, 2019 Learning a classifier from imbalanced data is a challenging problem in Machine learning. A dataset is said to be imbalanced when the number of instances belonging to one class is much less than the number of instances belonging to the other class ...
N. K. Sreeja
doaj +1 more source
MPSUBoost: A Modified Particle Stacking Undersampling Boosting Method
IEEE Access, 2022 Class imbalance problems are prevalent in the real world. In such cases, traditional supervised algorithms tend to have difficulty in recognizing minority data because the models are likely to maximize prediction accuracy by simply ignoring minority data.
Sang-Jin Kim, Dong-Joon Lim
doaj +1 more source
Data sorting of oversampling for imbalanced data.
, 2021 Data sorting of oversampling for imbalanced data.
Chang Wang (328274) +3 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source