Results 1 to 10 of about 378 (110)

Increase in Vascular Endothelial Growth Factor (VEGF) Expression and the Pathogenesis of iMCD-TAFRO [PDF]

Biomedicines
TAFRO (thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (F/R), renal failure (R), and organomegaly (O)) is a heterogeneous clinical subtype of idiopathic multicentric Castleman disease (iMCD) associated with a significantly poorer prognosis than other subtypes of iMCD.
Srkalovic G, Nijim S, Srkalovic M, Fajgenbaum D.   +3 more
europepmc   +6 more sources

Genetic basis for iMCD-TAFRO. [PDF]

Oncogene, 2020
TAFRO syndrome, a clinical subtype of idiopathic multicentric Castleman disease (iMCD), consists of a constellation of symptoms/signs including thrombocytopenia, anasarca, fever, reticulin fibrosis/renal dysfunction, and organomegaly. The etiology of iMCD-TAFRO and the basis for cytokine hypersecretion commonly seen in iMCD-TAFRO patients has not been ...
Yoshimi A, Trippett TM, Zhang N, Chen X, Penson AV, Arcila ME, Pichardo J, Baik J, Sigler A, Harada H, Fajgenbaum DC, Dogan A, Abdel-Wahab O, Xiao W.   +13 more
europepmc   +11 more sources

Increased mTORC2 pathway activation in lymph nodes of iMCD-TAFRO. [PDF]

J Cell Mol Med, 2022
AbstractIdiopathic multicentric Castleman disease (iMCD) is a rare and life‐threatening haematologic disorder involving polyclonal lymphoproliferation and organ dysfunction due to excessive cytokine production, including interleukin‐6 (IL‐6). Clinical trial and real‐world data demonstrate that IL‐6 inhibition is effective in 34–50% of patients.
Phillips AD, Kakkis JJ, Tsao PY, Pierson SK, Fajgenbaum DC.   +4 more
europepmc   +6 more sources

International definition of iMCD-TAFRO: future perspectives. [PDF]

J Clin Exp Hematop, 2022
Since thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly (TAFRO) syndrome was first proposed in 2010, there has been considerable progress in this area, particularly regarding its association with idiopathic multicentric Castleman disease (iMCD).
Nishimura Y, Nishimura MF, Sato Y.
europepmc   +5 more sources

Morphological and quantitative CT features of anterior mediastinal lesions in TAFRO syndrome and idiopathic multicentric Castleman disease. [PDF]

Front Immunol
We investigated the diagnostic challenges of TAFRO syndrome and idiopathic multicentric Castleman disease (iMCD), focusing on the usefulness of anterior mediastinal lesions for distinguishing the disease subtypes.
Mohamed L, Umeda M, Tsutsui S, Toya R, Umetsu A, Otsuka M, Endo Y, Shimizu T, Fukui S, Sumiyoshi R, Kawakami A, Koga T.   +11 more
europepmc   +5 more sources

TAFRO Syndrome Without Pathology Supporting Castleman Disease: To Be Treated as Idiopathic Multicentric Castleman Disease-TAFRO or a Distinct Disease Entity? [PDF]

Turk J Haematol
TAFRO syndrome, entailing thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly, was previously considered a subtype of idiopathic multicentric Castleman disease (iMCD-TAFRO), with the diagnosis requiring pathology supporting Castleman disease.
Li SY, Gao YH, Dang Y, Zhang L, Li J.
europepmc   +5 more sources

Exploring the Clinical Diversity of Castleman Disease and TAFRO Syndrome: A Japanese Multicenter Study on Lymph Node Distribution Patterns. [PDF]

Am J Hematol
Nagasaki University (長崎大学)博士(医学)Individuals diagnosed with Castleman disease (CD) and TAFRO syndrome (characterized by thrombocytopenia, anasarca, fever, bone marrow fibrosis, and organomegaly) displays a wide range of clinical symptoms, including ...
Otsuka M, Koga T, Sumiyoshi R, Fukui S, Kaneko Y, Shimizu T, Katsube A, Yano S, Masaki Y, Ide M, Yoshifuji H, Kitano M, Sato Y, Sawa N, Niiro H, Nakamura N, Fajgenbaum DC, van Rhee F, Kawakami A.   +18 more
europepmc   +4 more sources

Development and implementation of the International AIDA Network Castleman's disease registry. [PDF]

Front Med (Lausanne)
Castleman’s disease (CD) consists of a wide spectrum of rare disorders classified into unicentric CD and multicentric CD (MCD), based on the diffusion of disease distribution and the severity of clinical manifestations.
Vitale A, Sbalchiero J, Caggiano V, Lazzi S, Tharwat S, Fotis L, Lopalco G, Emmi G, Ruscitti P, Tufan A, Ragab G, Hissaria P, Dagna L, Wiesik-Szewczyk E, Hernández-Rodríguez J, González-Garcia A, Karamanakos A, Batu ED, Direskeneli H, Iannone F, Di Cola I, Kucuk H, Duran R, Saad MA, Ghanema M, Sikora M, Alibaz-Öner F, Beecher M, Ozen S, Cencini E, Bocchia M, Balistreri A, Fabiani C, Frediani B, Cantarini L, Zinzani P.   +35 more
europepmc   +7 more sources

Case Report: TAFRO syndrome misdiagnosed as liver cirrhosis due to persistent abdominal distension. [PDF]

Front Immunol
This report described a male patient presenting with recurrent fever, fatigue, persistent abdominal distension, and diarrhea, who was repeatedly misdiagnosed with decompensated cirrhosis at multiple hospitals.
Ma L, Gu R, Ma L, Li X, Yang L, Xie P, Xiao X, Gao F, Liu F, Shen C, Zhao C.   +10 more
europepmc   +3 more sources

Transcriptome analysis of the cytokine storm-related genes among the subtypes of idiopathic multicentric Castleman disease. [PDF]

J Clin Exp Hematop
Idiopathic multicentric Castleman disease (iMCD) is a type of Castleman disease unrelated to the Kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV8) infection.
Nishikori A, Nishimura MF, Tomida S, Chijimatsu R, Ueta H, Lai YC, Kawahara Y, Takeda Y, Ochi S, Haratake T, Ennishi D, Nakamura N, Momose S, Sato Y.   +13 more
europepmc   +3 more sources