Results 11 to 20 of about 378 (110)

Long-term tolerance and efficacy of siltuximab (anti-IL-6) in a young adult with idiopathic multicentric Castleman disease during COVID-19 [PDF]

European Journal of Case Reports in Internal Medicine, 2023
Background: Castleman disease (CD) is a rare lymphoproliferative disorder with various subtypes, including the HHV-8-negative/idiopathic multicentric CD (iMCD).
Chelsea Maedler-Kron, Helbies Bedier, Jean-Pierre Routy, Stéphane Isnard   +3 more
core   +4 more sources

TAFRO Syndrome Mimicking Solid Cancer and Successfully Treated by Tocilizumab: A Case and Literature Review

Journal of Cancer Research and Practice, 2023
TAFRO syndrome, or now formally termed idiopathic multicentric Castleman disease (iMCD) with thrombocytopenia, anasarca, fever, renal insufficiency or reticulin fibrosis, and organomegaly (iMCD-TAFRO), describes a unique subtype of iMCD.
Chia-Chi Wu, Pei-An Fu, Ya-Ting Hsu
core   +2 more sources

Distinct interleukin-6 production in IPL and TAFRO subtypes of idiopathic multicentric Castleman disease [PDF]

Haematologica
Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder characterized by systemic inflammation and lymphadenopathy.
Asami Nishikori, Daisuke Ennishi, David C. Fajgenbaum, Frits van Rhee, Himawari Ueta, Michael V. Gonzalez, Midori Filiz Nishimura, Rio Yamada, Ryota Chijimatsu, Sayaka Ochi, Shuji Momose, Tomohiro Koga, Tomoka Haratake, Toshihiro Ito, Yasuharu Sato, Yoshito Nishimura, Yudai Takeda, Yuri Kawahara   +17 more
core   +4 more sources

Longitudinal, natural history study reveals the disease burden of idiopathic multicentric Castleman disease [PDF]

Haematologica
Idiopathic multicentric Castleman disease (iMCD) is a rare hematologic disorder with heterogeneous presentations ranging from moderate constitutional symptoms to life-threatening multiorgan system involvement.
Adam Bagg, Daisy Alapat, David C. Fajgenbaum, Frits van Rhee, Gordan Srkalovic, Hongzhe Li, Joshua D. Brandstadter, Mary Jo Lechowicz, Mateo Sarmiento Bustamante, Megan S. Lim, Natalie Mango, Sheila K. Pierson, Yue Ren   +12 more
core   +5 more sources

DOENÇA DE CLASTLEMAN MULTICÊNTRICA COM SÍNDROME TAFRO (IMCD-TAFRO) − RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Objetivo: Descrição de um caso de Doença de Clastleman Multicêntrica (DCM) com Síndrome TAFRO associada. Material e métodos: Relato de caso descritivo, retrospectivo e observacional realizado a partir de dados obtidos por meio da análise de prontuários eletrônicos de paciente internado em instituição privada de referência em Hematologia no estado de ...
LB Anastacio, PDT Oliveira, JC Leite, LL Paula, HM Oliveira   +4 more
openaire   +3 more sources

Oligocentric Castleman disease: clinical characteristics and surgical outcomes from a single-centre retrospective study. [PDF]

Front Immunol
IntroductionOligocentric Castleman Disease (OCD), a distinct subtype of Castleman Disease (CD) intermediate between Unicentric (UCD) and idiopathic Multicentric (iMCD) forms, remains poorly characterised.MethodsThis study retrospectively analysed the ...
Duan Y, Gao X, Qian S, Hua R, Qiao H, Zhang S, Zong F, Li S, Song Y, Zhang M, Chen Q, Dong M, Zhang X.   +12 more
europepmc   +3 more sources

Biomarkers and Signaling Pathways Implicated in the Pathogenesis of Idiopathic Multicentric Castleman Disease/Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, Renal Insufficiency, and Organomegaly (TAFRO) Syndrome

Biomedicines
Idiopathic multicentric Castleman disease (iMCD) and TAFRO syndrome present a variety of symptoms thought to be caused by excessive inflammatory cytokines and chemokines, but the underlying mechanisms are unknown.
Atsushi Kawakami, Remi Sumiyoshi, Tomohiro Koga   +2 more
core   +2 more sources

Systemic sclerosis presenting TAFRO syndrome-like manifestations including renal glomerular microangiopathy: a case report and literature review

Immunological Medicine
TAFRO syndrome is a systemic inflammatory disorder of unknown etiology, and its diagnosis requires the exclusion of autoimmune diseases. A 42-year-old Japanese woman presented with TAFRO syndrome-like manifestations, but had undiagnosed limited-cutaneous
Dai Inoue, Hideki Nomura, Hiroko Ikeda, Hiroyuki Kawahara, Ichiro Mizushima, Mitsuhiro Kawano, Noriko Iwaki, Satoshi Hara, Yasufumi Masaki, Yasunori Iwata   +9 more
core   +2 more sources

TAFRO Syndrome: A Syndrome or a Subtype of Multicentric Castleman Disease?

Biomedicines
TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis of bone marrow/renal dysfunction, organomegaly) syndrome is a systemic inflammatory disorder of unknown etiology.
Kazue Takai
core   +2 more sources

Expert Perspective: Diagnosis and Treatment of Castleman Disease. [PDF]

Arthritis Rheumatol
Castleman disease (CD) is a major diagnostic challenge for rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region, whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Chen LYC, Zhang L, Fajgenbaum DC.
europepmc   +2 more sources