Results 21 to 30 of about 378 (110)

Heterogeneous Presentations of iMCD: A Single-Institution Case Series. [PDF]

Case Rep Hematol
Background Idiopathic multicentric Castleman disease (iMCD) is a rare lymphadenopathic disorder characterized by hyperplasia of multiple lymph nodes and can be associated with a wide range of symptoms and presentations, from mild disease to life‐threatening organ failure.
Kaur J, Sisk A, Zuckerman JE, Abdulhaq H.   +3 more
europepmc   +2 more sources

International Consensus Histopathological Criteria for Subtyping Idiopathic Multicentric Castleman Disease Based on Machine Learning Analysis. [PDF]

Am J Hematol
ABSTRACT Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder classified into three recognized clinical subtypes—idiopathic plasmacytic lymphadenopathy (IPL), TAFRO, and NOS. Although clinical criteria are available for subtyping, diagnostically challenging cases with overlapping histopathological features highlight ...
Nishimura MF, Haratake T, Nishimura Y, Nishikori A, Sumiyoshi R, Ujiie H, Kawahara Y, Koga T, Ueki M, Laczko D, Oksenhendler E, Fajgenbaum DC, van Rhee F, Kawakami A, Sato Y.   +14 more
europepmc   +2 more sources

The Evolution and Recent Advances in Diagnostic Criteria for Idiopathic Multicentric Castleman Disease. [PDF]

Am J Hematol
Idiopathic Multicentric Castleman Disease. ABSTRACT Idiopathic multicentric Castleman disease (iMCD) is a rare cytokine‐driven disorder characterized by systemic inflammation, organ dysfunction, and altered lymph node microscopic architecture. Over the past decade, diagnostic criteria have evolved significantly, integrating clinical, histopathological,
Alnoor F, Spies NC, Kumar J, Samghabadi P, Silva O, Luo MX, Chisholm KM, Zhang J, Rangel A, Ng D, Li P, Ohgami RS.   +11 more
europepmc   +2 more sources

TAFRO syndrome requiring combined IL 6 and IL 1 inhibition: a case report. [PDF]

Front Immunol
IntroductionTAFRO syndrome is a rare and severe variant of idiopathic multicentric Castleman disease (iMCD). The name-giving presentation is a combination of thrombocytopenia, anasarca, fever, reticulin fibrosis/renal dysfunction, and organomegaly.
Sultan AW, Grießhammer E, Hinrichs C, Trenkmann L, Oschlies I, Hanitsch LG, Haibel H, Schneider T, Leistner R.   +8 more
europepmc   +2 more sources

Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease [PDF]

, 2021
Thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly (TAFRO) syndrome is a heterogeneous entity manifesting with a constellation of symptoms described above that can occur in the context of idiopathic multicentric ...
Fajgenbaum, David C., Iwaki, Noriko, Izutsu, Koji, Kawano, Mitsuhiro, Maeda, Yoshinobu, Nakamura, Naoya, Nishikori, Asami, Nishimura, Midori Filiz, Nishimura, Yoshito, Oksenhendler, Eric, Otsuka, Fumio, Pierson, Sheila K., Sato, Yasuharu, Takeuchi, Kengo, van Rhee, Frits, Yoshizaki, Kazuyuki   +15 more
core   +1 more source

Historical and pathological overview of Castleman disease [PDF]

, 2022
Castleman disease consists of several lymphoproliferative subtypes that share some histological features in the lymph nodes. On the other hand, numerous clinical findings and etiologies make the disease challenging to understand.
Nishikori, Asami, Nishimura, Midori Filiz, Nishimura, Yoshito, Sato, Yasuharu, Yoshino, Tadashi   +4 more
core   +1 more source

Clinical Presentation, Treatment, and Outcomes of 28 Patients With Castleman Disease: A Retrospective Analysis of an Italian Cohort. [PDF]

EJHaem
ABSTRACT Background Castleman disease (CD) encompasses a range of heterogeneous non‐clonal lymphoproliferative disorders, including unicentric (UCD), and multicentric (MCD) forms. The latter is subdivided into HHV‐8+ MCD, POEMS‐MCD, and idiopathic‐MCD, not otherwise specified (iMCD‐NOS).
Cristinelli C, Merli M, Lucioni M, Gotti M, Sciarra R, Rattotti S, Carpi F, Favrin G, Bianchi B, Neri G, Coscia M, Gambacorta M, Passamonti F, Paulli M, Arcaini L.   +14 more
europepmc   +2 more sources

TAFRO Syndrome and Elusive Diagnosis of Idiopathic Multicentric Castleman Disease Treated with Empiric Anti-Interleukin-6 Therapy

Case Reports in Oncology, 2021
TAFRO syndrome is defined by the presence of thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis/renal dysfunction (R), and organomegaly (O) and can be seen with idiopathic multicentric Castleman disease (iMCD) or as an isolated process ...
Corinne Williams, Alexis Phillips, Vikram Aggarwal, Liron Barnea Slonim, David C. Fajgenbaum, Reem Karmali   +5 more
doaj   +1 more source

Idiopathic Multicentric Castleman Disease With Severe Eosinophilia and Diffuse Centrilobular Nodule-A Rare Case Report. [PDF]

Case Rep Hematol
Rationale Idiopathic multicentric Castleman disease (iMCD), also known as angiofollicular lymph node hyperplasia, is a rare inflammatory lymphoproliferative disease with diverse clinical presentations. We report a rare case of iMCD accompanied by severe eosinophilia and diffuse centrilobular pulmonary nodules, which have rarely been previously ...
Li X, Li S, Zhao T, Xu B, Du X, Song X, Wang Y.   +6 more
europepmc   +2 more sources

Idiopathic Plasmacytic Lymphadenopathy Forms an Independent Subtype of Idiopathic Multicentric Castleman Disease [PDF]

, 2022
Idiopathic multicentric Castleman disease (iMCD) is a type of Castleman disease that is not related to KSHV/HHV8 infection. Currently, iMCD is classified into iMCD-TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly) and iMCD ...
Maehama, Kanna, Momose, Shuji, Nakamura, Naoya, Nishikori, Asami, Nishimura, Midori Filiz, Nishimura, Yoshito, Ohsawa, Kumiko, Otsuka, Fumio, Sato, Yasuharu   +8 more
core   +2 more sources