Results 51 to 60 of about 378 (110)

Renal Pathologic Findings in TAFRO Syndrome: Is There a Continuum Between Thrombotic Microangiopathy and Membranoproliferative Glomerulonephritis? A Case Report and Literature Review

Frontiers in Immunology, 2019
Background: TAFRO syndrome is a clinical subtype of idiopathic multicentric Castleman disease (iMCD) that is characterized by thrombocytopenia, anasarca, fever and/or elevated serum C-reactive protein, renal dysfunction, and organomegaly.Case ...
Amélie Leurs, Amélie Leurs, Viviane Gnemmi, Arnaud Lionet, Loïc Renaud, Loïc Renaud, Jean-Baptiste Gibier, Marie-Christine Copin, Eric Hachulla, Pierre-Yves Hatron, David Launay, David Launay, David Fajgenbaum, Louis Terriou, Louis Terriou   +14 more
doaj   +1 more source

Next-generation sequencing of idiopathic multicentric and unicentric Castleman disease and follicular dendritic cell sarcomas

Blood Advances, 2018
: Castleman disease (CD) is a rare lymphoproliferative disorder subclassified as unicentric CD (UCD) or multicentric CD (MCD) based on clinical features and the distribution of enlarged lymph nodes with characteristic histopathology.
Alexandra Nagy, Aparna Bhaduri, Nahid Shahmarvand, Jahanbanoo Shahryari, James L. Zehnder, Roger A. Warnke, Tariq Mughal, Siraj Ali, Robert S. Ohgami   +8 more
doaj   +1 more source

Interleukin-6 in Castleman disease subtypes: look to tissues, not just blood [PDF]

Not ...
Luke Y.C. Chen, Mariam Goubran
core   +2 more sources

Efficacy of High‐Dose Intravenous Anakinra in Pediatric TAFRO Syndrome: Report of Two Cases and Literature Review

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly) syndrome is a rare, life‐threatening inflammatory condition linked to infections, neoplasms, and idiopathic multicentric Castleman disease. Interleukin (IL)‐6 inhibitors are the primary treatment, but refractory cases require alternatives. This
Serena Palmeri, Jacopo Ferro, Valentina Natoli, Caterina Matucci‐Cerinic, Riccardo Papa, Silvia Rosina, Stefania Sorrentino, Stefano Volpi, Valerio Gaetano Vellone, Marco Gattorno, Roberta Caorsi   +10 more
wiley   +1 more source

TAFRO syndrome is associated with anti-SSA/Ro60 antibodies, in contrast to idiopathic castleman disease

Scientific Reports
TAFRO syndrome is an acute systemic inflammatory disease characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis/renal dysfunction, and organomegaly.
Mirei Shirakashi, Yuri Nishida, Ran Nakashima, Masakazu Fujimoto, Ryosuke Hiwa, Hideaki Tsuji, Koji Kitagori, Shuji Akizuki, Akio Morinobu, Hajime Yoshifuji   +9 more
doaj   +1 more source

Interleukin‐6 transcripts up‐regulation in lymph nodes from unicentric and multicentric Castleman disease

eJHaem, Volume 5, Issue 6, Page 1182-1189, December 2024.
Abstract Introduction Castleman disease (CD) represents a spectrum of heterogeneous lymphoproliferative disorders sharing peculiar histopathological features, clinically subdivided into unicentric CD (UCD) and multicentric CD (MCD) and presenting with variable inflammatory symptoms.
Marco Lucioni, Gaia Morello, Caterina Cristinelli, Sara Fraticelli, Giuseppe Neri, Erica Travaglino, Marco Minetto, Francesca Antoci, Paolo Libretti, Marcello Gambacorta, Luca Arcaini, Claudio Tripodo, Marco Paulli   +12 more
wiley   +1 more source

Tacrolimus Treatment for TAFRO Syndrome

Biomedicines
TAFRO syndrome is an acute systemic inflammatory disorder characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly.
Taiichiro Shirai, Shinya Ichikawa, Jun Saegusa   +2 more
doaj   +1 more source

The value of a PET scan in selecting the best lymph node to biopsy, and confirming the diagnosis of idiopathic multicentric Castleman disease with HLH and EBV viremia in a previously healthy adult [PDF]

Introduction: Castleman disease (CD) is a rare lymphoproliferative disorder having a variegated clinical presentation. Diagnosis of the idiopathic HIV- and HHV8-negative multicentric CD (iMCD) subtype poses a challenge given its non-specific clinical ...
Erica Bitektine, Hamila Hagh-Daoust, Jean-Pierre Routy, René P. Michel, Stephane Isnard   +4 more
core   +2 more sources

Idiopathic multicentric Castleman disease with marrow fibrosis and extramedullary hematopoiesis

European Journal of Haematology, Volume 113, Issue 6, Page 833-841, December 2024.
Abstract Background Idiopathic multicentric Castleman disease (iMCD) is a rare inflammatory disorder mediated by excessive proinflammatory cytokine signaling, most notably by interleukin 6 (IL‐6). IL‐6‐induced extramedullary hematopoiesis (EMH) has been reported in murine models of iMCD. Herein we present four cases of iMCD with EMH in humans.
Marley Blommers, Sorin Selegean, Richard K. Wood, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, E. Ashley Wiley, Emilie Comeau, Allam A. Shawwa, Stefan Rose‐John, David C. Fajgenbaum, Luke Y. C. Chen   +10 more
wiley   +1 more source

Concurrent idiopathic multicentric Castleman disease with TAFRO and Sjögren’s syndrome in a young patient: a challenging diagnostic overlap

European Journal of Case Reports in Internal Medicine
Background: Idiopathic multicentric Castleman disease (iMCD) with TAFRO syndrome (characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, organomegaly) is a recently described disorder. The diagnostic criteria for iMCD-TAFRO
Maria Carolina Carvalho, Matilde Coimbra, João Fernandes Serodio, José Delgado Alves   +3 more
doaj   +1 more source