Results 111 to 120 of about 19,050 (169)

Comparative in-vitro Intrinsic Clearance of Imipramine in Multiple Species Liver Microsomes: Human, Rat, Mouse and Dog

, 2012
Imipramine is a renowned tricyclic anti-depressant molecule. It is known to be highly potent and efficient as compared to any other antidepressants available.
J. Singh, A. Solanki, V. Shirsath
semanticscholar   +1 more source

Metabolism of Imipramine by Microorganisms

Journal of Pharmaceutical Sciences, 1981
The microbial metabolism of imipramine was studied using selected fungal organisms. The major microbial metabolites were isolated, and their structures were established by spectroscopic analyses (particularly 13C-NMR) and by comparison with authentic samples.
Alice M. Clark, John K. Baker, George A. Capiton, Charles D. Huffordx   +3 more
openaire   +3 more sources

Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Report of the NIMH Collaborative Study Group comparing lithium carbonate, imipramine, and a lithium carbonate-imipramine combination.

Archives of General Psychiatry, 1984
In a double-blind, long-term follow-up study, 117 bipolar patients received lithium carbonate, imipramine hydrochloride, or both and 150 unipolar patients received lithium carbonate, imipramine, both lithium carbonate and imipramine, or placebo.
R. Prien, D. Kupfer, P. Mansky, J. Small, Vincente B. Tuason, C. Voss, Wayne E. Johnson   +6 more
semanticscholar   +1 more source

A Controlled Trial of Imipramine

British Journal of Psychiatry, 1964
A comparison of imipramine and electroplexy in 31 depressed patients selected for the latter treatment has already been reported (Robin and Harris, 1962). The following study concerns depressed patients chosen for conservative measures.
A. A. Robin, G. E. Langley
openaire   +3 more sources

Double-blind, placebo-controlled comparison of imipramine and paroxetine in the treatment of bipolar depression.

American Journal of Psychiatry, 2001
OBJECTIVE This study compared the efficacy and safety of paroxetine and imipramine with that of placebo in the treatment of bipolar depression in adult outpatients stabilized on a regimen of lithium.
C. Nemeroff, D. Evans, L. Gyulai, G. Sachs, C. Bowden, I. Gergel, R. Oakes, C. Pitts   +7 more
semanticscholar   +1 more source

Antidepressants for the treatment of generalized anxiety disorder. A placebo-controlled comparison of imipramine, trazodone, and diazepam.

Archives of General Psychiatry, 1993
OBJECTIVE The current study examines whether antidepressants, contrary to current thinking, are safe and effective treatments for generalized anxiety disorder (GAD) not complicated by depression or panic disorder.
K. Rickels, R. Downing, E. Schweizer, Howard H Hassman   +3 more
semanticscholar   +1 more source

The treatment of chronic depression, part 3: psychosocial functioning before and after treatment with sertraline or imipramine.

Journal of Clinical Psychiatry, 1998
BACKGROUND Previous research has suggested that depressed patients, and particularly chronically depressed patients, have significant impairments in many areas of their lives. While previous studies suggested that these "psychosocial" impairments improve
I. Miller, G. Keitner, A. Schatzberg, D. Klein, M. Thase, A. Rush, J. Markowitz, David S. Schlager, S. Kornstein, S. Davis, W. Harrison, M. Keller   +11 more
semanticscholar   +1 more source

Imipramine for Nightmares

JAMA: The Journal of the American Medical Association, 1974
To the Editor.— In connection with the question by Dr. Leo Sell and the answer by Dr. Anthony Kales (227:1066, 1974), I would like to draw your attention to clinical observations we have made in a study of 12 sleepwalking and pavor nocturnus children. We used 25 to 50 mg of imipramine before bedtime with great success. From the psychotherapeutic point
openaire   +2 more sources

Tritiated imipramine binding sites are decreased in the frontal cortex of suicides.

Science, 1982
Binding characteristics of tritiated imipramine were determined in the frontal cortex of suicides and well-matched controls. Maximal binding was significantly lower in brains from the suicides.
M. Stanley, J. Virgilio, S. Gershon
semanticscholar   +1 more source

Hepatic sensitivity to imipramine

The American Journal of Digestive Diseases, 1977
A case of significant hepatic reaction related to imipramine is presented, documented by challenge with imipramine and liver biopsy. The mechanism, while not entirely clear, is presumed to involve hypersensitivity or induction of toxic metabolites.
Dennis Pavlinac, John S. Davis, Gary A. Weaver   +2 more
openaire   +2 more sources