Results 111 to 120 of about 51,042 (305)
Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens [PDF]
, 2013 There is accumulating evidence that the nucleus accumbens (NAc) has an important role in the pathophysiology of depression. As the NAc is a key component in the neural circuitry of reward, it has been hypothesized that anhedonia, a core symptom of ...
A Dranovsky +32 more
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Opportunities and Challenges of Population Pharmacogenomics
Annals of Human Genetics, Volume 89, Issue 5, Page 384-397, September 2025.ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou +3 more
wiley +1 more source
Research in Pharmaceutical Sciences, 2016 High-performance liquid chromatography (HPLC) methods employing ultraviolet (UV) detector are not sufficiently sensitive to measure the low plasma concentrations following single oral dose of imipramine.
Mahboubeh Rezazadeh, Jaber Emami
doaj
The Treatment of Depressive Conditions with Imipramine (G 22355) [PDF]
, 1958 H. E. Lehmann +2 more
openalex +1 more source
Revista Brasileira de Psiquiatria, 2009 OBJECTIVE Clinical findings suggest that ketamine may be used for the treatment of major depression. The present study aimed to compare behavioral effects and brain Creatine kinase activity in specific brain regions after administration of ketamine and ...
L. C. Assis +7 more
semanticscholar +1 more source
Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia [PDF]
, 2016 The use of tyrosine kinase inhibitors (TKI), including nilotinib, has revolutionized the treatment of chronic myeloid leukemia (CML). However current unmet clinical needs include combating activation of additional survival signaling pathways in ...
Arbiser +47 more
core +3 more sources
The Locus Coeruleus—Noradrenergic System in the Healthy and Diseased Brain: A Narrative Review
European Journal of Neurology, Volume 32, Issue 9, September 2025.The locus coeruleus (LC) is a small brainstem nucleus that serves as the main source of noradrenaline for the central nervous system, influencing a wide range of cognitive and physiological processes. By integrating anatomical, neurochemical, and functional perspectives, this review provides a comprehensive understanding of the LC‐NA system's role in ...
Sielke Caestecker +5 more
wiley +1 more source
The Effect of Sympathetic Antagonists on the Antidepressant Action of Alprazolam
Libyan Journal of Medicine, 2008 Alprazolam is an anti-anxiety drug shown to be effective in the treatment of depression. In this study, the effect of sympathetic receptor antagonists on alprazolam–induced antidepressant action was studied using a mouse model of forced swimming ...
Gorash ZM +4 more
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Disturbance of Motor Function During Treatment with Imipramine [PDF]
, 1959 Avianna Foster, N. P. Lancaster
openalex +1 more source
The management of nocturnal enuresis in children [PDF]
, 2016 Introduction : Nocturnal enuresis is more prevalent in the male gender. Studies such as that by Butler & McKenna (2002) show how nocturnal enuresis is hereditary, with approximately 50% of the children affected if one parent has suffered from it ...
Galea, Keith +2 more
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