Results 31 to 40 of about 4,736 (263)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

An automated approach to the quantitation of vocalizations and vocal learning in the songbird. [PDF]

open access: yesPLoS Computational Biology, 2018
Studies of learning mechanisms critically depend on the ability to accurately assess learning outcomes. This assessment can be impeded by the often complex, multidimensional nature of behavior.
David G Mets, Michael S Brainard
doaj   +1 more source

Johannine Ethics: An Exegetical-Theological Summary and a ‘Desiderative’ Extension of Mimesis

open access: yesReligions, 2022
If we consider the Johannine literature to have primarily espoused an exemplary (rather than an imperatival) ethical paradigm, our understanding of its moral teaching becomes much richer.
Paul Anthony Hartog
doaj   +1 more source

Profound Leadership Strategies: Transcending the Leadership Crisis in the Age of Artificial Intelligence

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of organizational leadership amidst the rapid advancements in artificial intelligence (AI). It explores a broadly experienced and documented crisis in leadership, due in part to the disruptive nature of AI and emerging technology.
Rachel Wlodarsky, Davin Carr Chellman
wiley   +1 more source

Neonatal imitation in rhesus macaques.

open access: yesPLoS Biology, 2006
The emergence of social behaviors early in life is likely crucial for the development of mother-infant relationships. Some of these behaviors, such as the capacity of neonates to imitate adult facial movements, were previously thought to be limited to ...
Pier F Ferrari   +5 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem   +17 more
wiley   +1 more source

Safe and Human‐Like Trajectory Planning of Self‐Driving Cars: A Constraint Imitative Method

open access: yesAdvanced Intelligent Systems, 2023
Safe and human‐like trajectory planning is crucial for self‐driving cars. While model‐based planning has demonstrated reliability, it is beneficial to incorporate human demonstrations and align the results with human behaviors. This work aims at bridging
Mingyang Cui   +6 more
doaj   +1 more source

Dancing in Your Head: An Interdisciplinary Review

open access: yesFrontiers in Psychology, 2021
The aim of this review is to highlight the most relevant contributions on dance in neuroscientific research. Neuroscience has analyzed the mirror system through neuroimaging techniques, testing its role in imitative learning, in the recognition of other ...
Andrea Zardi   +4 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

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