Results 71 to 80 of about 177,603 (326)

Estimated Probabililty of Chest Injury During an International Space Station Mission [PDF]

, 2013
The Integrated Medical Model (IMM) is a decision support tool that is useful to spaceflight mission planners and medical system designers when assessing risks and optimizing medical systems. The IMM project maintains a database of medical conditions that
Brooker, John E., Lewandowski, Beth E., Milo, Eric A., Myers, Jerry G., Jr., Weaver, Aaron S.   +4 more
core   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, EarlyView.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

PRELID1 and VDAC3 Coordinate a Senescence‐Like State in Germinal Center B Cells to Promote IL‐7–Driven Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao, Huimeng Xu, Xinghua Zhuo, Shupeng Hu, Lanhui Huang, Zhe Hao, Jianxiong Chen, Yulu Wang, Jun Zhou   +8 more
wiley   +1 more source

Evidence of soft bound behaviour in analogue memristive devices for neuromorphic computing

Scientific Reports, 2018
The development of devices that can modulate their conductance under the application of electrical stimuli constitutes a fundamental step towards the realization of synaptic connectivity in neural networks. Optimization of synaptic functionality requires
Jacopo Frascaroli, Stefano Brivio, Erika Covi, Sabina Spiga   +3 more
doaj   +1 more source

A Cost-Effective Vehicle Localization Solution Using an Interacting Multiple Model−Unscented Kalman Filters (IMM-UKF) Algorithm and Grey Neural Network

Sensors, 2017
In this paper, we propose a cost-effective localization solution for land vehicles, which can simultaneously adapt to the uncertain noise of inertial sensors and bridge Global Positioning System (GPS) outages. First, three Unscented Kalman filters (UKFs)
Qimin Xu, Xu Li, Ching-Yao Chan
doaj   +1 more source

Randomised, open-label, phase II study of Gemcitabine with and without IMM-101 for advanced pancreatic cancer [PDF]

, 2016
Background: Immune Modulation and Gemcitabine Evaluation-1, a randomised, open-label, phase II, first-line, proof of concept study (NCT01303172), explored safety and tolerability of IMM-101 (heat-killed Mycobacterium obuense; NCTC 13365) with ...
A Bilici, A Carrato, A Wang-Gillam, Alberto Zaniboni, Andrew Gaya, Andrés J Muñoz Martín, Angus G Dalgleish, Bartomeu Massuti, Carlos Fernandez-Martos, Cristina Granetto, D Fowler, David Chang, DD Von Hoff, Demetris Papamichael, Douglas JA Adamson, DT Le, E Poplin, F Braiteh, G Colucci, HA Burris 3rd, J Stebbing, Jose M Vieitez, Justin Stebbing, Karen McAdam, Kevin J Carroll, KS Gunturu, M Haas, M Hidalgo, MA Tempero, Paolo Bidoli, Raymond McDermott, Rob Glynne-Jones, Robert Diaz-Beveridge, Roberto Pazo-Cid, S Bazzi, Satvinder S Mudan, Seema Safia Arif, Shama Wagle, SM Wormann, Sue Cheeseman, T Conroy, T Nywening, T Seufferlein, Y Pico de Coana   +43 more
core   +4 more sources

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Use interactive multimedia to improve your programming course [PDF]

, 2001
This paper reports first year students’ experiences with multimedia-based learning for programming and its influence on students obtained from two case studies at Napier and Brunel universities.
Cairncross, S, Choi, S, Kalganova, T
core  

Topological Materials and Related Applications

Advanced Electronic Materials, EarlyView.
This review covers topological materials—including topological insulators, quantum valley Hall and quantum spin Hall insulators, and topological Weyl and Dirac semimetals—as well as their most recent advancements in fields such as spintronics, electronics, photonics, thermoelectrics, and catalysis.
Carlo Grazianetti, Roberto Mantovan, Emanuele Longo, Harold J. W. Zandvliet, Pantelis Bampoulis, Yu Pan, Fan Li, Xia Wang, Payton Downey, Alessandro Molle   +9 more
wiley   +1 more source

The Interactive Multiple Model Strategy With Matrix Form Mode Probability for Models With Different State Vectors

IEEE Access
The Interactive Multiple Model (IMM) strategy is widely used for systems with multiple operating modes characterized by varying dynamics. This approach is particularly effective when a system undergoes sudden transitions between different modes, such as ...
Ehsan Majma, Ryan Ahmed, Uday Deshpande, Saeid Habibi   +3 more
doaj   +1 more source