Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt [PDF]
Microbiology Spectrum, 2023 Human cytomegalovirus (HCMV) is an opportunistic pathogen that infects most of the population. The complex 236 kbp genome encodes more than 170 open reading frames, whose expression is temporally regulated by both viral transcriptional regulators and ...
Eleonora Forte +11 more
doaj +3 more sources
Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma. [PDF]
Cancer Res, 2015 Abstract Glioblastoma (GBM) is the most common and aggressive human brain tumor. Human cytomegalovirus (HCMV) immediate-early (IE) proteins that are endogenously expressed in GBM cells are strong viral transactivators with oncogenic properties.
Soroceanu L +16 more
europepmc +7 more sources
Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle. [PDF]
PLoS Pathogens, 2009 The gamma-herpesvirus Epstein-Barr virus (EBV) persists for life in infected individuals despite the presence of a strong immune response. During the lytic cycle of EBV many viral proteins are expressed, potentially allowing virally infected cells to be ...
Nathan P Croft +10 more
doaj +12 more sources
Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner. [PDF]
PLoS Pathogens, 2020 Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ and ...
Liling Shan +12 more
doaj +2 more sources
The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses [PDF]
Viruses, 2009 The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency.
Michael Nevels, Christina Paulus
doaj +2 more sources
Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function [PDF]
Viruses, 2020 The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections cause severe disease in immunosuppressed patients and congenital defects in ...
Catherine S. Adamson +1 more
doaj +2 more sources
Non-covalent Interaction With SUMO Enhances the Activity of Human Cytomegalovirus Protein IE1
Frontiers in Cell and Developmental Biology, 2021 Viruses interact with the host cellular pathways to optimize cellular conditions for replication. The Human Cytomegalovirus (HCMV) Immediate-Early protein 1 (IE1) is the first viral protein to express during infection.
Vasvi Tripathi +2 more
doaj +1 more source
Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells. [PDF]
PLoS ONE, 2016 Protein kinase inhibitors can be used as tools to identify proteins and pathways required for virus replication. Using virus replication assays and western blotting we found that the widely used protein kinase inhibitor BAY61-3606 inhibits replication of
Catherine M K Ho +5 more
doaj +1 more source
Time course of immediate early gene protein expression in the spinal cord following conditioning stimulation of the sciatic nerve in rats. [PDF]
PLoS ONE, 2015 Long-term potentiation induced by conditioning electrical stimulation of afferent fibers is a widely studied form of synaptic plasticity in the brain and the spinal cord.
Ognjen Bojovic +4 more
doaj +1 more source
Microbiology Spectrum, 2021 Human cytomegalovirus (HCMV) immediate-early 2 (IE2) protein is the major transactivator for viral gene expression and is required for lytic replication.
Salome Manska, Cyprian C. Rossetto
doaj +1 more source