Results 1 to 10 of about 175,104 (304)

Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma. [PDF]

Cancer Res, 2015
Abstract Glioblastoma (GBM) is the most common and aggressive human brain tumor. Human cytomegalovirus (HCMV) immediate-early (IE) proteins that are endogenously expressed in GBM cells are strong viral transactivators with oncogenic properties. Here, we show how HCMV IEs are preferentially expressed in glioma stem–like cells (GSC), where
Soroceanu L, Matlaf L, Khan S, Akhavan A, Singer E, Bezrookove V, Decker S, Ghanny S, Hadaczek P, Bengtsson H, Ohlfest J, Luciani-Torres MG, Harkins L, Perry A, Guo H, Soteropoulos P, Cobbs CS.   +16 more
europepmc   +7 more sources

A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts [PDF]

mBio, 2017
ABSTRACT Herpes simplex virus 1 (HSV-1) genes are transcribed by cellular RNA polymerase II (RNA Pol II). While four viral immediate early proteins (ICP4, ICP0, ICP27, and ICP22) function in some capacity in viral transcription, the mechanism by which ICP22 functions remains unclear.
Neal A. DeLuca, Jill A. Dembowski, Hannah L. Fox   +2 more
openaire   +4 more sources

Role of Human Cytomegalovirus Immediate-Early Proteins in Cell Growth Control [PDF]

Journal of Virology, 2000
ABSTRACT Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that has been implicated in several disorders, including an association between HCMV reactivation and the overproliferation of arterial smooth muscle cells observed in restenosis.
Castillo, Jonathan Patrick, Yurochko, Andrew D., Kowalik, Timothy F.   +2 more
openaire   +5 more sources

Human cytomegalovirus immediate early proteins upregulate endothelial p53 function [PDF]

FEBS Letters, 2000
Infected endothelial cells are found to be resistant to apoptosis possibly mediated by p53 cytoplasmic sequestration. We explored whether the immediate early 84 kDa protein (IE84) of cytomegalovirus (CMV) is responsible for p53 cytoplasmic sequestration.
Xing L. Wang, Xing L. Wang, Gregory M. Vercellotti, John D. Belcher, Paul H. Marker, Jun Wang, Linda J. Burns, David E.L. Wilcken   +7 more
openaire   +5 more sources

Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter [PDF]

Journal of Virology, 1990
The immediate-early two (IE2) gene products of human cytomegalovirus negatively regulate gene expression from the major immediate-early promoter in permissive human fibroblasts. A mutational analysis of the IE2 proteins indicated that the carboxyl-terminal region is required for negative regulation. The IE2 proteins that lack amino acid residues 365 to
Mark F. Stinski, Cheryl L. Malone, T W Hermiston   +2 more
openaire   +3 more sources

Transcriptional activation by the pseudorabies virus immediate early protein. [PDF]

Genes & Development, 1990
The pseudorabies virus immediate early (IE) protein is a potent, promiscuous activator of viral and cellular gene transcription. The promiscuous action of IE protein has led to the suggestion that it functions by an unusual mechanism. Here, we show that IE protein has the two essential features of a typical cellular activator: (1) a transcriptional ...
Katherine J. Martin, Michael R. Green, James W. Lillie   +2 more
openaire   +2 more sources

Gem: an Induced, Immediate Early Protein Belonging to the Ras Family [PDF]

Science, 1994
A gene encoding a 35-kilodalton guanosine triphosphate (GTP)-binding protein, Gem, was cloned from mitogen-induced human peripheral blood T cells. Gem and Rad, the product of a gene overexpressed in skeletal muscle in individuals with Type II diabetes, constitute a new family of Ras-related GTP-binding proteins. The distinct structural features of this
Maguire, J., Santoro, T., Jensen, P., Siebenlist, U., Yewdell, J., Kelly, K.   +5 more
openaire   +4 more sources

TAF-like functions of human cytomegalovirus immediate-early proteins [PDF]

Journal of Virology, 1997
The human cytomegalovirus (HCMV) major immediate-early (IE) proteins IEP86 (IE2(579aa)) and IEP72 (IE1(491aa)) can transcriptionally activate a variety of simple promoters containing a TATA element and one upstream transcription factor binding site. In our previous studies, transcriptional activation was shown to correlate with IEP86 binding to both ...
James C. Alwine, David M. Lukac, Noam Y. Harel, Naoko Tanese   +3 more
openaire   +2 more sources

Immunological evasion of immediate-early varicella zoster virus proteins [PDF]

Immunogenetics, 2016
The varicella zoster virus (VZV) causes the childhood disease commonly known as chickenpox and can later in life reactivate as herpes zoster. The adaptive immune system is known to play an important role in suppressing VZV reactivation. A central aspect of this system is the presentation of VZV-derived peptides by the major histocompatibility complex ...
Dmitry Fedorov, Viggo Van Tendeloo, Kris Laukens, Pieter Meysman, Benson Ogunjimi, Benson Ogunjimi   +5 more
openaire   +3 more sources

Multimerization of ICP0, a herpes simplex virus immediate-early protein [PDF]

Journal of Virology, 1992
ICP0, a herpes simplex virus immediate-early gene product, is a highly phosphorylated nuclear protein that is a potent activator of virus and host genes. Using biochemical and genetic assays employing plasmids encoding mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we mutant forms of ICP0 and a recombinant adenovirus that ...
Saul Silverstein, Christos A. Panagiotidis, Jianxing Chen   +2 more
openaire   +3 more sources