Results 1 to 10 of about 473,081 (212)

Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt [PDF]

Microbiology Spectrum, 2023
Human cytomegalovirus (HCMV) is an opportunistic pathogen that infects most of the population. The complex 236 kbp genome encodes more than 170 open reading frames, whose expression is temporally regulated by both viral transcriptional regulators and ...
Eleonora Forte, Ming Li, Fatma Ayaloglu Butun, Qiaolin Hu, Eva Maria Borst, Matthew J. Schipma, Andrea Piunti, Ali Shilatifard, Scott S. Terhune, Michael Abecassis, Jeffery L. Meier, Mary Hummel   +11 more
doaj   +2 more sources

Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma. [PDF]

Cancer Res, 2015
Abstract Glioblastoma (GBM) is the most common and aggressive human brain tumor. Human cytomegalovirus (HCMV) immediate-early (IE) proteins that are endogenously expressed in GBM cells are strong viral transactivators with oncogenic properties.
Soroceanu L, Matlaf L, Khan S, Akhavan A, Singer E, Bezrookove V, Decker S, Ghanny S, Hadaczek P, Bengtsson H, Ohlfest J, Luciani-Torres MG, Harkins L, Perry A, Guo H, Soteropoulos P, Cobbs CS.   +16 more
europepmc   +6 more sources

Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner. [PDF]

PLoS Pathogens, 2020
Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ and ...
Liling Shan, Shuang Li, Jan Meeldijk, Bernadet Blijenberg, Astrid Hendriks, Karlijn J W M van Boxtel, Sara P H van den Berg, Ian J Groves, Martin Potts, Adriana Svrlanska, Thomas Stamminger, Mark R Wills, Niels Bovenschen   +12 more
doaj   +2 more sources

A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts [PDF]

mBio, 2017
Herpes simplex virus 1 (HSV-1) genes are transcribed by cellular RNA polymerase II (RNA Pol II). While four viral immediate early proteins (ICP4, ICP0, ICP27, and ICP22) function in some capacity in viral transcription, the mechanism by which ICP22 ...
Hannah L. Fox, Jill A. Dembowski, Neal A. DeLuca   +2 more
doaj   +3 more sources

Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones [PDF]

Virology, 1988
The conditions that permit the interaction of immediate-early proteins of murine cytomegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the regulatory major immediate-early protein, interacts with DNA and dissociates at salt concentrations ...
Münch, Konrad, Keil, Günther M., Messerle, Martin, Koszinowski, Ulrich H.   +3 more
openaire   +5 more sources

The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses [PDF]

Viruses, 2009
The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency.
Michael Nevels, Christina Paulus
doaj   +2 more sources

Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter [PDF]

Journal of Virology, 1990
The immediate-early two (IE2) gene products of human cytomegalovirus negatively regulate gene expression from the major immediate-early promoter in permissive human fibroblasts. A mutational analysis of the IE2 proteins indicated that the carboxyl-terminal region is required for negative regulation. The IE2 proteins that lack amino acid residues 365 to
T W, Hermiston, C L, Malone, M F, Stinski   +2 more
openaire   +2 more sources

Non-covalent Interaction With SUMO Enhances the Activity of Human Cytomegalovirus Protein IE1

Frontiers in Cell and Developmental Biology, 2021
Viruses interact with the host cellular pathways to optimize cellular conditions for replication. The Human Cytomegalovirus (HCMV) Immediate-Early protein 1 (IE1) is the first viral protein to express during infection.
Vasvi Tripathi, Kiran Sankar Chatterjee, Ranabir Das   +2 more
doaj   +1 more source

TAF-like functions of human cytomegalovirus immediate-early proteins [PDF]

Journal of Virology, 1997
The human cytomegalovirus (HCMV) major immediate-early (IE) proteins IEP86 (IE2(579aa)) and IEP72 (IE1(491aa)) can transcriptionally activate a variety of simple promoters containing a TATA element and one upstream transcription factor binding site. In our previous studies, transcriptional activation was shown to correlate with IEP86 binding to both ...
D M, Lukac, N Y, Harel, N, Tanese, J C, Alwine   +3 more
openaire   +2 more sources

Human cytomegalovirus immediate early proteins upregulate endothelial p53 function [PDF]

FEBS Letters, 2000
Infected endothelial cells are found to be resistant to apoptosis possibly mediated by p53 cytoplasmic sequestration. We explored whether the immediate early 84 kDa protein (IE84) of cytomegalovirus (CMV) is responsible for p53 cytoplasmic sequestration.
Wang, Jun, Marker, Paul H, Belcher, John D, Wilcken, David E.L, Burns, Linda J, Vercellotti, Gregory M, Wang, Xing L   +6 more
openaire   +2 more sources