Results 101 to 110 of about 891,156 (376)
Neurobiology of Disease, 2005 Extracellular nucleotides exert a variety of biological actions through different subtypes of P2 receptors. Here we characterized in the human neuroblastoma SH-SY5Y cells the simultaneous presence of various P2 receptors, belonging to the P2X ionotropic ...
Fabio Cavaliere +7 more
doaj
Embryonic demise caused by targeted disruption of a cysteine protease Dub-2. [PDF]
PLoS ONE, 2012 BACKGROUND: A plethora of biological metabolisms are regulated by the mechanisms of ubiquitination, wherein this process is balanced with the action of deubiquitination system.
Kwang-Hyun Baek +9 more
doaj +1 more source
Circulation, 1999 BACKGROUND Restenotic and atherosclerotic lesions often contain smooth muscle cells (SMCs), which display high rates of proliferation and apoptosis. Human cytomegalovirus (HCMV) may increase the incidence of restenosis and predispose to atherosclerosis ...
Koichi Tanaka +7 more
semanticscholar +1 more source
Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
FEBS Open Bio, EarlyView.Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa +13 more
wiley +1 more source
Functional interaction of nuclear domain 10 and its components with cytomegalovirus after infections: cross-species host cells versus native cells. [PDF]
PLoS ONE, 2011 Species-specificity is one of the major characteristics of cytomegaloviruses (CMVs) and is the primary reason for the lack of a mouse model for the direct infection of human CMV (HCMV). It has been determined that CMV cross-species infections are blocked
Ruth Cruz Cosme +2 more
doaj +1 more source
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2018 While the causes of myriad medical and infectious illnesses have been identified, the etiologies of neuropsychiatric illnesses remain elusive. This is due to two major obstacles.
Ketan K. Marballi, Amelia L. Gallitano
doaj +1 more source
Caspase-Dependent Cleavage of an Immediate Early Herpes Simplex Virus Protein [PDF]
, 2009 Advisor: Marie Nguyen of Des Moines UniversityHerpes Simplex Virus 1 (HSV-1) is a member of the Herpesviridae family. All herpesviruses cause life-long infections that shift between latent and lyticand have many treatments but no cures.
Craig, Trevor, Pradhan, Prajakta
core +1 more source
Synthesis of (Immediate-Early) Proteins in Vero Cells Infected with Pseudorabies Virus
Journal of General Virology, 1984 The synthesis of alpha (immediate-early) polypeptides in Vero cells infected with pseudorabies virus was studied. Cycloheximide was added at the beginning of infection and removed several hours later. The accumulated alpha mRNA was translated either in vivo in the presence of actinomycin D to prevent further mRNA synthesis, or in vitro. In intact cells
Fenwick, M, Mcmenamin, M
openaire +4 more sources
FEBS Open Bio, EarlyView.Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper +5 more
wiley +1 more source