Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma. [PDF]
Cancer Res, 2015 Glioblastoma (GBM) is the most common and aggressive human brain tumor. Human cytomegalovirus (HCMV) immediate-early (IE) proteins that are endogenously expressed in GBM cells are strong viral transactivators with oncogenic properties.
Soroceanu L +16 more
europepmc +8 more sources
The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses [PDF]
Viruses, 2009 The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency.
Michael Nevels, Christina Paulus
doaj +3 more sources
A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts [PDF]
mBio, 2017 Herpes simplex virus 1 (HSV-1) genes are transcribed by cellular RNA polymerase II (RNA Pol II). While four viral immediate early proteins (ICP4, ICP0, ICP27, and ICP22) function in some capacity in viral transcription, the mechanism by which ICP22 ...
Hannah L. Fox +2 more
doaj +4 more sources
The Core Histone-binding Region of the Murine Cytomegalovirus 89K Immediate Early Protein [PDF]
Journal of General Virology, 1991 The gene regulatory immediate early protein, pp89, of murine cytomegalovirus interacts with both DNA-associated and isolated histones in vitro. We characterized the histone-binding region of pp89 and its cellular localization during cell division to ...
Karin Münch +3 more
core +7 more sources
Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt [PDF]
Microbiology Spectrum, 2023 Human cytomegalovirus (HCMV) is an opportunistic pathogen that infects most of the population. The complex 236 kbp genome encodes more than 170 open reading frames, whose expression is temporally regulated by both viral transcriptional regulators and ...
Eleonora Forte +11 more
doaj +2 more sources
Analysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infection. [PDF]
PLoS One, 2014 Post-translational modification of proteins by members of the small ubiquitin-like modifier (SUMO) is involved in diverse cellular functions. Many viral proteins are SUMO targets and also interact with the cellular SUMOylation system.
Kim ET +5 more
europepmc +2 more sources
Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle. [PDF]
PLoS Pathogens, 2009 The gamma-herpesvirus Epstein-Barr virus (EBV) persists for life in infected individuals despite the presence of a strong immune response. During the lytic cycle of EBV many viral proteins are expressed, potentially allowing virally infected cells to be ...
Nathan P Croft +10 more
doaj +9 more sources
Role of Human Cytomegalovirus Immediate-Early Proteins in Cell Growth Control [PDF]
Journal of Virology, 2000 ABSTRACT Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that has been implicated in several disorders, including an association between HCMV reactivation and the overproliferation of arterial smooth muscle cells observed in restenosis.
Jonathan Castillo +2 more
semanticscholar +6 more sources
E2F/Rb Family Proteins Mediate Interferon Induced Repression of Adenovirus Immediate Early Transcription to Promote Persistent Viral Infection. [PDF]
PLoS Pathogens, 2016 Interferons (IFNs) are cytokines that have pleiotropic effects and play important roles in innate and adaptive immunity. IFNs have broad antiviral properties and function by different mechanisms. IFNs fail to inhibit wild-type Adenovirus (Ad) replication
Yueting Zheng +2 more
doaj +2 more sources
Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner. [PDF]
PLoS Pathogens, 2020 Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ and ...
Liling Shan +12 more
doaj +2 more sources