Results 11 to 20 of about 480,670 (335)

A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts [PDF]

mBio, 2017
Herpes simplex virus 1 (HSV-1) genes are transcribed by cellular RNA polymerase II (RNA Pol II). While four viral immediate early proteins (ICP4, ICP0, ICP27, and ICP22) function in some capacity in viral transcription, the mechanism by which ICP22 ...
Hannah L. Fox, Jill A. Dembowski, Neal A. DeLuca   +2 more
doaj   +3 more sources

Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones [PDF]

Virology, 1988
The conditions that permit the interaction of immediate-early proteins of murine cytornegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the ...
Alberts, Bookout, Ebeling, Einck, Everett, Faber, Freeman, Green, Günther M. Keil, Hay, Hermiston, Isenberg, Kedes, Keil, Keil, Keil, Keil, Konrad Munch, Koszinowski, Koszinowski, Koszinowski, Kristie, Kristie, Martin Messerle, O'Hare, Ohlenbusch, Purifoy, Reddehase, Rigby, Stein, Tevethia, Ulrich H. Koszinowski, Weissbach   +32 more
core   +4 more sources

Binding of the pseudorabies virus immediate-early protein to single-stranded DNA [PDF]

Journal of Virology, 1987
In an attempt to correlate the ability to activate transcription with affinity for single-stranded DNA, both wild-type and temperature-sensitive pseudorabies virus immediate-early proteins were tested for the ability to bind to single-stranded DNA columns. Wild-type and temperature-sensitive immediate-early proteins bound to nonspecific single-stranded
Caryl A. Chlan, Cynthia L. Coulter, L T Feldman   +2 more
openalex   +3 more sources

Data from Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma

, 2023
<div>Abstract<p>Glioblastoma (GBM) is the most common and aggressive human brain tumor. Human cytomegalovirus (HCMV) immediate-early (IE) proteins that are endogenously expressed in GBM cells are strong viral transactivators with oncogenic properties.
Liliana Soroceanu, Lisa Matlaf, Sabeena Khan, Armin Akhavan, Eric A. Singer, Vladimir Bezrookove, Stacy A. Decker, Saleena Ghanny, Piotr Hadaczek, Henrik Bengtsson, John R. Ohlfest, Maria-Gloria Luciani-Torres, Lualhati Harkins, Arie Perry, Hong Guo, Patricia Soteropoulos, Charles Cobbs   +16 more
openalex   +2 more sources

Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter [PDF]

Journal of Virology, 1990
The immediate-early two (IE2) gene products of human cytomegalovirus negatively regulate gene expression from the major immediate-early promoter in permissive human fibroblasts. A mutational analysis of the IE2 proteins indicated that the carboxyl-terminal region is required for negative regulation. The IE2 proteins that lack amino acid residues 365 to
T W, Hermiston, C L, Malone, M F, Stinski   +2 more
openaire   +2 more sources

TAF-like functions of human cytomegalovirus immediate-early proteins [PDF]

Journal of Virology, 1997
The human cytomegalovirus (HCMV) major immediate-early (IE) proteins IEP86 (IE2(579aa)) and IEP72 (IE1(491aa)) can transcriptionally activate a variety of simple promoters containing a TATA element and one upstream transcription factor binding site. In our previous studies, transcriptional activation was shown to correlate with IEP86 binding to both ...
D M, Lukac, N Y, Harel, N, Tanese, J C, Alwine   +3 more
openaire   +2 more sources

Human cytomegalovirus immediate early proteins upregulate endothelial p53 function [PDF]

FEBS Letters, 2000
Infected endothelial cells are found to be resistant to apoptosis possibly mediated by p53 cytoplasmic sequestration. We explored whether the immediate early 84 kDa protein (IE84) of cytomegalovirus (CMV) is responsible for p53 cytoplasmic sequestration.
Wang, Jun, Marker, Paul H, Belcher, John D, Wilcken, David E.L, Burns, Linda J, Vercellotti, Gregory M, Wang, Xing L   +6 more
openaire   +2 more sources

Immunological evasion of immediate-early varicella zoster virus proteins [PDF]

Immunogenetics, 2016
The varicella zoster virus (VZV) causes the childhood disease commonly known as chickenpox and can later in life reactivate as herpes zoster. The adaptive immune system is known to play an important role in suppressing VZV reactivation. A central aspect of this system is the presentation of VZV-derived peptides by the major histocompatibility complex ...
Pieter, Meysman, Dmitry, Fedorov, Viggo, Van Tendeloo, Benson, Ogunjimi, Kris, Laukens   +4 more
openaire   +2 more sources

Multimerization of ICP0, a herpes simplex virus immediate-early protein [PDF]

Journal of Virology, 1992
ICP0, a herpes simplex virus immediate-early gene product, is a highly phosphorylated nuclear protein that is a potent activator of virus and host genes. Using biochemical and genetic assays employing plasmids encoding mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we mutant forms of ICP0 and a recombinant adenovirus that ...
J, Chen, C, Panagiotidis, S, Silverstein
openaire   +2 more sources

Transcriptional activation by the pseudorabies virus immediate early protein. [PDF]

Genes & Development, 1990
The pseudorabies virus immediate early (IE) protein is a potent, promiscuous activator of viral and cellular gene transcription. The promiscuous action of IE protein has led to the suggestion that it functions by an unusual mechanism. Here, we show that IE protein has the two essential features of a typical cellular activator: (1) a transcriptional ...
K J, Martin, J W, Lillie, M R, Green
openaire   +2 more sources