Results 271 to 280 of about 888,744 (374)

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

open access: yesAdvanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo   +15 more
wiley   +1 more source

The Sequence and Antiapoptotic Functional Domains of the Human Cytomegalovirus UL37 Exon 1 Immediate Early Protein Are Conserved in Multiple Primary Strains

open access: bronze, 2001
Wail Hayajneh   +7 more
openalex   +1 more source

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

open access: yesAdvanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen   +7 more
wiley   +1 more source

Blockchain‐Empowered H‐CPS Architecture for Smart Agriculture

open access: yesAdvanced Science, EarlyView.
This article reviews the current system architectures for smart agriculture and proposes a blockchain‐empowered hierarchical cyber‐physical system (H‐CPS) framework. It discusses the challenges and outlines future research directions, including the use of semantic blockchain to handle complex data and models.
Xiaoding Wang   +8 more
wiley   +1 more source

Elucidation of Mechanism of Action in Drug Invention: Using Stable Isotope Tracers to Unravel Biochemical Kinetics. [PDF]

open access: yesPharmacol Res Perspect
Kohnz RA   +10 more
europepmc   +1 more source

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