Results 21 to 30 of about 175,104 (304)

The immediate early gene product EGR1 and polycomb group proteins interact in epigenetic programming during chondrogenesis. [PDF]

PLoS ONE, 2013
Initiation of and progression through chondrogenesis is driven by changes in the cellular microenvironment. At the onset of chondrogenesis, resting mesenchymal stem cells are mobilized in vivo and a complex, step-wise chondrogenic differentiation program
Frank Spaapen, Guus G H van den Akker, Marjolein M J Caron, Peggy Prickaerts, Celine Rofel, Vivian E H Dahlmans, Don A M Surtel, Yvette Paulis, Finja Schweizer, Tim J M Welting, Lars M Eijssen, Jan Willem Voncken   +11 more
doaj   +1 more source

Detection of Human Cytomegalovirus in Atherosclerotic Carotid Arteries in Humans

Journal of the Formosan Medical Association, 2008
Atherosclerosis plays an important role in stroke. A microbiological infection has been suggested to be involved in the pathogenesis of atherosclerosis, in particular the human cytomegalovirus (HCMV).
Li Yi, De-Xin Wang, Zi-Jing Feng
doaj   +1 more source

Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle.

PLoS Pathogens, 2009
The gamma-herpesvirus Epstein-Barr virus (EBV) persists for life in infected individuals despite the presence of a strong immune response. During the lytic cycle of EBV many viral proteins are expressed, potentially allowing virally infected cells to be ...
Nathan P Croft, Claire Shannon-Lowe, Andrew I Bell, Daniëlle Horst, Elisabeth Kremmer, Maaike E Ressing, Emmanuel J H J Wiertz, Jaap M Middeldorp, Martin Rowe, Alan B Rickinson, Andrew D Hislop   +10 more
doaj   +1 more source

Cytomegalovirus immediate-early 1 proteins form a structurally distinct protein class with adaptations determining cross-species barriers.

PLoS Pathogens, 2021
Restriction factors are potent antiviral proteins that constitute a first line of intracellular defense by blocking viral replication and spread. During co-evolution, however, viruses have developed antagonistic proteins to modulate or degrade the ...
Johannes Schweininger, Myriam Scherer, Franziska Rothemund, Eva-Maria Schilling, Sonja Wörz, Thomas Stamminger, Yves A Muller   +6 more
doaj   +1 more source

Binding of the pseudorabies virus immediate-early protein to single-stranded DNA [PDF]

Journal of Virology, 1987
In an attempt to correlate the ability to activate transcription with affinity for single-stranded DNA, both wild-type and temperature-sensitive pseudorabies virus immediate-early proteins were tested for the ability to bind to single-stranded DNA columns. Wild-type and temperature-sensitive immediate-early proteins bound to nonspecific single-stranded
L T Feldman, C A Chlan, C Coulter
openaire   +3 more sources

Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones [PDF]

Virology, 1988
The conditions that permit the interaction of immediate-early proteins of murine cytomegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the regulatory major immediate-early protein, interacts with DNA and dissociates at salt concentrations ...
Münch, Konrad, Keil, Günther M., Messerle, Martin, Koszinowski, Ulrich H.   +3 more
openaire   +4 more sources

Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA.

PLoS Pathogens, 2010
Histone deacetylation plays a pivotal role in regulating human cytomegalovirus gene expression. In this report, we have identified candidate HDAC1-interacting proteins in the context of infection by using a method for rapid immunoisolation of an epitope ...
Scott S Terhune, Nathaniel J Moorman, Ileana M Cristea, John Paul Savaryn, Christian Cuevas-Bennett, Michael P Rout, Brian T Chait, Thomas Shenk   +7 more
doaj   +1 more source

E2F/Rb Family Proteins Mediate Interferon Induced Repression of Adenovirus Immediate Early Transcription to Promote Persistent Viral Infection. [PDF]

PLoS Pathogens, 2016
Interferons (IFNs) are cytokines that have pleiotropic effects and play important roles in innate and adaptive immunity. IFNs have broad antiviral properties and function by different mechanisms. IFNs fail to inhibit wild-type Adenovirus (Ad) replication
Yueting Zheng, Thomas Stamminger, Patrick Hearing   +2 more
doaj   +1 more source

Analysis of the human herpesvirus-6 immediate-early 1 protein

Journal of General Virology, 2002
Herpesvirus immediate-early (IE) gene products play key roles in establishing productive infections, regulating reactivation from latency and evading immune recognition. Analyses of HHV-6 IE gene expression have revealed that the IE1 gene of the HHV-6A and HHV-6B variants exhibits a higher degree of sequence variation than other regions of the genome ...
Julie D. Fox, Richard Caswell, Richard J. Stanton, Gavin William Grahame Wilkinson, E. J. Sherratt   +4 more
openaire   +3 more sources

Epigenetic Control of Cytomegalovirus Latency and Reactivation

Viruses, 2013
Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate ...
Mary Hummel, Shixian Yan, Zheng Zhang, Michael Abecassis, Xue-feng Liu, Xueqiong Wang   +5 more
doaj   +1 more source