CD8 CTL from Genital Herpes Simplex Lesions: Recognition of Viral Tegument and Immediate Early Proteins and Lysis of Infected Cutaneous Cells [PDF]
Journal of Immunology, 2001 David M. Koelle +5 more
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Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter [PDF]
Journal of Virology, 1990 The immediate-early two (IE2) gene products of human cytomegalovirus negatively regulate gene expression from the major immediate-early promoter in permissive human fibroblasts. A mutational analysis of the IE2 proteins indicated that the carboxyl-terminal region is required for negative regulation. The IE2 proteins that lack amino acid residues 365 to
Mark F. Stinski +2 more
openaire +3 more sources
Non-covalent Interaction With SUMO Enhances the Activity of Human Cytomegalovirus Protein IE1
Frontiers in Cell and Developmental Biology, 2021 Viruses interact with the host cellular pathways to optimize cellular conditions for replication. The Human Cytomegalovirus (HCMV) Immediate-Early protein 1 (IE1) is the first viral protein to express during infection.
Vasvi Tripathi +2 more
doaj +1 more source
Transcriptional activation by the pseudorabies virus immediate early protein. [PDF]
Genes & Development, 1990 The pseudorabies virus immediate early (IE) protein is a potent, promiscuous activator of viral and cellular gene transcription. The promiscuous action of IE protein has led to the suggestion that it functions by an unusual mechanism. Here, we show that IE protein has the two essential features of a typical cellular activator: (1) a transcriptional ...
Katherine J. Martin +2 more
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Gem: an Induced, Immediate Early Protein Belonging to the Ras Family [PDF]
Science, 1994 A gene encoding a 35-kilodalton guanosine triphosphate (GTP)-binding protein, Gem, was cloned from mitogen-induced human peripheral blood T cells. Gem and Rad, the product of a gene overexpressed in skeletal muscle in individuals with Type II diabetes, constitute a new family of Ras-related GTP-binding proteins. The distinct structural features of this
Maguire, J. +5 more
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Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins [PDF]
Journal of Virology, 1998 ABSTRACT The immediate-early (IE) proteins of herpes simplex virus (HSV) function on input genomes and affect many aspects of host cell metabolism to ensure the efficient expression and regulation of the remainder of the genome and, subsequently, the production of progeny virions. Due to the many and varied effects of IE proteins
L. A. Samaniego +2 more
semanticscholar +4 more sources
Inhibition of IFN-γ Signaling by an Epstein-Barr Virus Immediate-Early Protein [PDF]
Immunity, 2001 AbstractViruses have evolved elaborate mechanisms to target many aspects of the host's immune response. The cytokine IFN-γ plays a central role in resistance of the host to infection via direct antiviral effects as well as modulation of the immune response.
Thomas E. Morrison +4 more
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Immunological evasion of immediate-early varicella zoster virus proteins [PDF]
Immunogenetics, 2016 The varicella zoster virus (VZV) causes the childhood disease commonly known as chickenpox and can later in life reactivate as herpes zoster. The adaptive immune system is known to play an important role in suppressing VZV reactivation. A central aspect of this system is the presentation of VZV-derived peptides by the major histocompatibility complex ...
Dmitry Fedorov +5 more
openaire +3 more sources
Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells. [PDF]
PLoS ONE, 2016 Protein kinase inhibitors can be used as tools to identify proteins and pathways required for virus replication. Using virus replication assays and western blotting we found that the widely used protein kinase inhibitor BAY61-3606 inhibits replication of
Catherine M K Ho +5 more
doaj +1 more source