Results 31 to 40 of about 175,104 (304)

Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression

mBio, 2021
Interferons (IFNs) are one of the hallmarks of host antiviral immunity. IFNs exert their antiviral activities through the induction of IFN-stimulated genes (ISGs) and antiviral proteins; however, the mechanism by which ISGs inhibit adenovirus (Ad ...
Aniska Chikhalya, Meike Dittmann, Yueting Zheng, Sook-Young Sohn, Charles M. Rice, Patrick Hearing   +5 more
doaj   +1 more source

NPR1-Independent Activation of Immediate Early Salicylic Acid-Responsive Genes in Arabidopsis

Molecular Plant-Microbe Interactions, 2004
Salicylic acid (SA) is a key signal for the activation of defense genes in response to stress. The activation of late defense genes by SA, such as PR-1, involves the participation of the NPR1 protein.
Carolina Uquillas, Ingrid Letelier, Francisca Blanco, Xavier Jordana, Loreto Holuigue   +4 more
doaj   +1 more source

Phosphorylation of the Human Cytomegalovirus 86-Kilodalton Immediate-Early Protein IE2 [PDF]

Journal of Virology, 1998
ABSTRACTWe have investigated the phosphorylation state of the human cytomegalovirus 86-kDa immediate-early (IE) protein IEP86 from transfected and infected cells. We show that multiple domains of IEP86 are phosphorylated by cellular kinases, both in vitro and in vivo.
James C. Alwine, Noam Y. Harel
openaire   +3 more sources

Characterization of Regulatory Functions of the HSV-1 Immediate-Early Protein ICP22

Virology, 1996
Previous work has shown that the 68-kDa immediate-early protein of herpes simplex virus type 1 (HSV-1), also known as ICP22, is involved in the control of viral gene expression, although the precise mechanism remains to be elucidated. In order to study the function(s) of this protein, we constructed expression vectors containing the coding sequence of ...
Alberto L. Epstein, Irma Machuca, Bernard Jacquemont, Herve Berthomme, Catherine Prod'hon   +4 more
openaire   +2 more sources

DNA-binding properties of a herpes simplex virus immediate early protein [PDF]

Journal of Virology, 1982
The herpes simplex virus alpha, or immediate early, protein ICP4 has been shown to be central to the control of the early stages of virus replication. The detailed mechanism of this control is unknown. In this communication we show that purified ICP4 was unable to bind to DNA even though the protein was capable of such activity in a crude extract ...
K L Powell, M J Freeman
openaire   +3 more sources

Immediate early gene X-1 interacts with proteins that modulate apoptosis [PDF]

Biochemical and Biophysical Research Communications, 2004
Immediate early gene X-1 (IEX-1) modulates apoptosis, cellular growth, mechanical strain-induced cardiac hypertrophy, and vascular intimal hyperplasia. To determine how IEX-1 alters apoptosis, we performed yeast two-hybrid studies using IEX-1 as the "bait" protein, and examined interactions between IEX-1 and proteins expressed by a human kidney cDNA ...
Elena Frank, Rajiv Kumar, Hee Jeong Im, Ward Lutz   +3 more
openaire   +3 more sources

Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II.

PLoS Pathogens, 2020
Herpesvirus late promoters activate gene expression after viral DNA synthesis has begun. Alphaherpesviruses utilize a viral immediate-early protein to do this, whereas beta- and gammaherpesviruses primarily use a 6-member set of viral late-acting ...
Ming Li, Christopher B Ball, Geoffrey Collins, Qiaolin Hu, Donal S Luse, David H Price, Jeffery L Meier   +6 more
doaj   +1 more source

Identifying the key regulators orchestrating Epstein-Barr virus reactivation

Frontiers in Microbiology
Epstein-Barr virus (EBV) infects more than 90% of the human population worldwide and establishes lifelong infection in hosts by switching between latent and lytic infection.
Yaohao Wang, Jingwen Yu, Yonggang Pei
doaj   +1 more source

Endothelin-1 Activates MAPKs and Modulates Cell Cycle Proteins in OKP Cells

Journal of the Formosan Medical Association, 2007
The signaling mechanisms through which endothelin (ET)-1 induces hyperplasia of the renal tubular epithelium are largely unknown. Methods: These mechanisms were explored using ETB-overexpressing opossum kidney (OKP) cells as a model system. Results: ET-1
Tzong-Shinn Chu, Ming-Shiou Wu, Kwan-Dun Wu, Bor-Shen Hsieh   +3 more
doaj   +1 more source

The Accumulation of Arc (an Immediate Early Gene) mRNA by the Inhibition of Protein Synthesis

Journal of Pharmacological Sciences, 2003
Arc (activity-regulated cytoskeleton-associated protein) gene is one of the neuron-specific immediate early genes induced by neural activity. The regulation of Arc gene expression is unknown. We found that Arc mRNA is expressed constitutively in L929 cells, a mouse fibroblast cell line, and was, not transiently, increased by the calcium ionophore ...
Naomasa Miki, Eiichi Taira, Hisashi Ichikawa, Takahiro Fujimoto   +3 more
openaire   +5 more sources