Results 41 to 50 of about 175,104 (304)

Identification of Cellular Proteins that Interact with Human Cytomegalovirus Immediate-Early Protein 1 by Protein Array Assay

Viruses, 2013
Human cytomegalovirus (HCMV) gene expression during infection is characterized as a sequential process including immediate-early (IE), early (E), and late (L)-stage gene expression.
Francisco Puerta Martínez, Qiyi Tang
doaj   +1 more source

Plasma Proteins as Biomarkers of Mortality After Total Body Irradiation in Mice

Dose-Response, 2020
During large-scale acute radiation exposure, rapidly distinguishing exposed individuals from nonexposed individuals is necessary. Identifying those exposed to high and potentially lethal radiation doses, and in need of immediate treatment, is especially ...
Hanjiang Fu, Yong Xue, Fei Su, Kexin Ding, Yuan Wang, Haiyue Yu, Jie Zhu, Qing Li, Changhui Ge, Xiaofei Zheng   +9 more
doaj   +1 more source

Transcriptional activation of the adenoviral genome is mediated by capsid protein VI. [PDF]

PLoS Pathogens, 2012
Gene expression of DNA viruses requires nuclear import of the viral genome. Human Adenoviruses (Ads), like most DNA viruses, encode factors within early transcription units promoting their own gene expression and counteracting cellular antiviral defense ...
Sabrina Schreiner, Ruben Martinez, Peter Groitl, Fabienne Rayne, Remi Vaillant, Peter Wimmer, Guillaume Bossis, Thomas Sternsdorf, Lisa Marcinowski, Zsolt Ruzsics, Thomas Dobner, Harald Wodrich   +11 more
doaj   +1 more source

Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication

Viruses, 2014
UL34 is one of the ~50 genes of human cytomegalovirus (HCMV) required for replication in cell culture in human fibroblasts. UL34 encodes highly related early (UL34a) and late (UL34b) proteins that are virtually identical, with the early protein ...
Rico Rana, Bonita J. Biegalke
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Duplicate US1 Genes of Duck Enteritis Virus Encode a Non-essential Immediate Early Protein Localized to the Nucleus

Frontiers in Cellular and Infection Microbiology, 2020
The duplicate US1 genes of duck enteritis virus (DEV) encode a protein with a conserved Herpes_IE68 domain, which was found to be closely related to the herpes virus immediate early regulatory protein family and is highly conserved among counterparts ...
Yangguang Li, Yangguang Li, Yangguang Li, Ying Wu, Ying Wu, Ying Wu, Mingshu Wang, Mingshu Wang, Mingshu Wang, YunChao Ma, YunChao Ma, YunChao Ma, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Dekang Zhu, Dekang Zhu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Qiao Yang, Qiao Yang, Qiao Yang, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Ling Zhang, Ling Zhang, Ling Zhang, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Leichang Pan, Leichang Pan, Bin Tian, Bin Tian, Mujeeb Ur Rehman, Mujeeb Ur Rehman, Xiaoyue Chen, Xiaoyue Chen, Anchun Cheng, Anchun Cheng, Anchun Cheng   +60 more
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function

Viruses, 2020
The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections cause severe disease in immunosuppressed patients and congenital defects in ...
Catherine S. Adamson, Michael M. Nevels   +1 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Quantitative Proteomic Characterization of Foreign Body Response towards Silicone Breast Implants Identifies Chronological Disease-Relevant Biomarker Dynamics

Biomolecules, 2023
The etiology of exaggerated fibrous capsule formation around silicone mammary implants (SMI) is multifactorial but primarily induced by immune mechanisms towards the foreign material silicone.
Ines Schoberleitner, Klaus Faserl, Bettina Sarg, Daniel Egle, Christine Brunner, Dolores Wolfram   +5 more
doaj   +1 more source