Results 61 to 70 of about 891,156 (376)

Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes [PDF]

, 2008
Background: Endothelin-1 stimulates Gq protein-coupled receptors to promote proliferation in dividing cells or hypertrophy in terminally differentiated cardiomyocytes.
Alsafi, A., Clerk, Angela, Cullingford, Timothy E., Dennis, Jayne L., Ekere, C., Fuller, Stephen John, Game, Laurence, Giraldo, Alejandro, Kemp, Timothy J., Markou, T., Pikkarainern, Sampsa, Sugden, Peter H., Zoumpoulidou, Georgia   +12 more
core   +2 more sources

Identifying the key regulators orchestrating Epstein-Barr virus reactivation

Frontiers in Microbiology
Epstein-Barr virus (EBV) infects more than 90% of the human population worldwide and establishes lifelong infection in hosts by switching between latent and lytic infection.
Yaohao Wang, Jingwen Yu, Yonggang Pei
doaj   +1 more source

Endothelin-1 Activates MAPKs and Modulates Cell Cycle Proteins in OKP Cells

Journal of the Formosan Medical Association, 2007
The signaling mechanisms through which endothelin (ET)-1 induces hyperplasia of the renal tubular epithelium are largely unknown. Methods: These mechanisms were explored using ETB-overexpressing opossum kidney (OKP) cells as a model system. Results: ET-1
Tzong-Shinn Chu, Ming-Shiou Wu, Kwan-Dun Wu, Bor-Shen Hsieh   +3 more
doaj   +1 more source

Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II.

PLoS Pathogens, 2020
Herpesvirus late promoters activate gene expression after viral DNA synthesis has begun. Alphaherpesviruses utilize a viral immediate-early protein to do this, whereas beta- and gammaherpesviruses primarily use a 6-member set of viral late-acting ...
Ming Li, Christopher B Ball, Geoffrey Collins, Qiaolin Hu, Donal S Luse, David H Price, Jeffery L Meier   +6 more
doaj   +1 more source

The Accumulation of Arc (an Immediate Early Gene) mRNA by the Inhibition of Protein Synthesis

Journal of Pharmacological Sciences, 2003
Arc (activity-regulated cytoskeleton-associated protein) gene is one of the neuron-specific immediate early genes induced by neural activity. The regulation of Arc gene expression is unknown. We found that Arc mRNA is expressed constitutively in L929 cells, a mouse fibroblast cell line, and was, not transiently, increased by the calcium ionophore ...
Naomasa Miki, Eiichi Taira, Hisashi Ichikawa, Takahiro Fujimoto   +3 more
openaire   +5 more sources

Identification of Cellular Proteins that Interact with Human Cytomegalovirus Immediate-Early Protein 1 by Protein Array Assay

Viruses, 2013
Human cytomegalovirus (HCMV) gene expression during infection is characterized as a sequential process including immediate-early (IE), early (E), and late (L)-stage gene expression.
Francisco Puerta Martínez, Qiyi Tang
doaj   +1 more source

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins [PDF]

, 2017
Using a high throughput screening methodology we surveyed a collection of largely uncharacterized validated or suspected kinase inhibitors for anti-human cytomegalovirus (HCMV) activity.
Beelontally, Rooksarr, Davison, Andrew J., Deng, Xianming, Goodmaker, Charles J., Gray, Nathanael S., Ho, Catherine M.K., Lau, Betty, Strang, Blair L., Swanson, Chad M., Wang, Jinhua, Wilkie, Gavin S.   +10 more
core   +2 more sources

Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication

Viruses, 2014
UL34 is one of the ~50 genes of human cytomegalovirus (HCMV) required for replication in cell culture in human fibroblasts. UL34 encodes highly related early (UL34a) and late (UL34b) proteins that are virtually identical, with the early protein ...
Rico Rana, Bonita J. Biegalke
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Plasma Proteins as Biomarkers of Mortality After Total Body Irradiation in Mice

Dose-Response, 2020
During large-scale acute radiation exposure, rapidly distinguishing exposed individuals from nonexposed individuals is necessary. Identifying those exposed to high and potentially lethal radiation doses, and in need of immediate treatment, is especially ...
Hanjiang Fu, Yong Xue, Fei Su, Kexin Ding, Yuan Wang, Haiyue Yu, Jie Zhu, Qing Li, Changhui Ge, Xiaofei Zheng   +9 more
doaj   +1 more source