Results 61 to 70 of about 480,670 (335)
Plasma Proteins as Biomarkers of Mortality After Total Body Irradiation in Mice
Dose-Response, 2020 During large-scale acute radiation exposure, rapidly distinguishing exposed individuals from nonexposed individuals is necessary. Identifying those exposed to high and potentially lethal radiation doses, and in need of immediate treatment, is especially ...
Hanjiang Fu +9 more
doaj +1 more source
Transcriptional activation of the adenoviral genome is mediated by capsid protein VI. [PDF]
PLoS Pathogens, 2012 Gene expression of DNA viruses requires nuclear import of the viral genome. Human Adenoviruses (Ads), like most DNA viruses, encode factors within early transcription units promoting their own gene expression and counteracting cellular antiviral defense ...
Sabrina Schreiner +11 more
doaj +1 more source
Temporal regulation of murine cytomegalovirus transcription and mapping of viral RNA synthesized at immediate early times after infection [PDF]
, 1984 The replication of murine cytomegalovirus strain Smith in murine embryonic fibroblasts was investigated at immediate early, early, and late times after infection.
Ebeling-Keil, Angelika +2 more
core +1 more source
Revealing nascent proteomics in signaling pathways and cell differentiation. [PDF]
, 2018 Regulation of gene expression at the level of protein synthesis is a crucial element in driving how the genetic landscape is expressed. However, we are still limited in technologies that can quantitatively capture the immediate proteomic changes that ...
Burlingame, Alma L +8 more
core +1 more source
Human Cytomegalovirus Immediate-Early 2 Protein IE86 Blocks Virus-Induced Chemokine Expression [PDF]
Journal of Virology, 2006 ABSTRACT The effect of human cytomegalovirus (HCMV) gene expression on cytokine (beta interferon) and chemokine (RANTES, MIG, MCP-2, MIP-1α, and interleukin-8) expression was examined. We demonstrate that HCMV gene expression is required to suppress the transcriptional induction of these cytokines and that the HCMV immediate-early 2 ...
R Travis, Taylor, Wade A, Bresnahan
openaire +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Characterization of the murine cytomegalovirus early transcription unit e1 that is induced by immediate-early proteins [PDF]
, 1990 The regulation of murine cytomegalovirus early (E) gene expression was studied in the cell line B25, which is stably transfected with the immediate-early ie1/ie3 gene complex.
Bühler, Bernhard +3 more
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Biomolecules, 2023 The etiology of exaggerated fibrous capsule formation around silicone mammary implants (SMI) is multifactorial but primarily induced by immune mechanisms towards the foreign material silicone.
Ines Schoberleitner +5 more
doaj +1 more source
The Biosemiotic Approach in Biology : Theoretical Bases and Applied Models [PDF]
, 2011 Biosemiotics is a growing fi eld that investigates semiotic processes in the living realm in an attempt to combine the fi ndings of the biological sciences and semiotics. Semiotic processes are more or less what biologists have typically referred to as “
El-Hani, Charbel +3 more
core +1 more source