Identifying the key regulators orchestrating Epstein-Barr virus reactivation
Frontiers in MicrobiologyEpstein-Barr virus (EBV) infects more than 90% of the human population worldwide and establishes lifelong infection in hosts by switching between latent and lytic infection.
Yaohao Wang, Jingwen Yu, Yonggang Pei
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Endothelin-1 Activates MAPKs and Modulates Cell Cycle Proteins in OKP Cells
Journal of the Formosan Medical Association, 2007 The signaling mechanisms through which endothelin (ET)-1 induces hyperplasia of the renal tubular epithelium are largely unknown. Methods: These mechanisms were explored using ETB-overexpressing opossum kidney (OKP) cells as a model system. Results: ET-1
Tzong-Shinn Chu +3 more
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Properties of an equine herpesvirus 1 mutant devoid of the internal inverted repeat sequence of the genomic short region [PDF]
, 2011 The 150kbp genome of equine herpesvirus-1 (EHV-1) is composed of a unique long (UL) region and a unique short (Us) segment, which is flanked by identical internal and terminal repeat (IR and TR) sequences of 12.7kbp.
Ahn, ByungChul +3 more
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Viruses, 2013 Human cytomegalovirus (HCMV) gene expression during infection is characterized as a sequential process including immediate-early (IE), early (E), and late (L)-stage gene expression.
Francisco Puerta MartÃnez, Qiyi Tang
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The Accumulation of Arc (an Immediate Early Gene) mRNA by the Inhibition of Protein Synthesis
Journal of Pharmacological Sciences, 2003 Arc (activity-regulated cytoskeleton-associated protein) gene is one of the neuron-specific immediate early genes induced by neural activity. The regulation of Arc gene expression is unknown. We found that Arc mRNA is expressed constitutively in L929 cells, a mouse fibroblast cell line, and was, not transiently, increased by the calcium ionophore ...
Naomasa Miki +3 more
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Lateralization, maturation, and anteroposterior topography in the lateral habenula revealed by ZIF268/EGR1 immunoreactivity and labeling history of neuronal activity [PDF]
, 2015 We report habenular lateralization in a simple transgenic mouse model used for labeling a facet of neuronal activity history. A transgenic construct comprised of a zif268/egr1 immediate-early gene promoter and a gene for normal Venus fluorescent protein ...
Hamada Michito +6 more
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Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes [PDF]
, 2008 Background: Endothelin-1 stimulates Gq protein-coupled receptors to promote proliferation in dividing cells or hypertrophy in terminally differentiated cardiomyocytes.
Alsafi, A. +12 more
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Plasma Proteins as Biomarkers of Mortality After Total Body Irradiation in Mice
Dose-Response, 2020 During large-scale acute radiation exposure, rapidly distinguishing exposed individuals from nonexposed individuals is necessary. Identifying those exposed to high and potentially lethal radiation doses, and in need of immediate treatment, is especially ...
Hanjiang Fu +9 more
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Transcriptional activation of the adenoviral genome is mediated by capsid protein VI. [PDF]
PLoS Pathogens, 2012 Gene expression of DNA viruses requires nuclear import of the viral genome. Human Adenoviruses (Ads), like most DNA viruses, encode factors within early transcription units promoting their own gene expression and counteracting cellular antiviral defense ...
Sabrina Schreiner +11 more
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Virtual Identification of Essential Proteins Within the Protein Interaction Network of Yeast [PDF]
, 2005 Topological analysis of large scale protein-protein interaction networks (PINs) is important for understanding the organisational and functional principles of individual proteins. The number of interactions that a protein has in a PIN has been observed to be correlated with its indispensability.
arxiv +1 more source