Results 81 to 90 of about 175,104 (304)
Mapping of human herpesvirus 6 immediate–early 2 protein transactivation domains
Virology, 2006 The immediate-early 2 (IE2) protein of human herpesvirus 6 (HHV-6) is a potent transactivator of multiple cellular and viral promoters. Deletion mutants of HHV-6 variant A IE2 allowed us to map functional transactivation domains acting on complex and minimal promoter sequences.
Louis Flamand +2 more
openaire +3 more sources
Advanced Functional Materials, EarlyView.This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley +1 more source
Characterisation of immediate early 1 protein of primate and rodent cytomegaloviruses
, 2023 The HCMV protein hIE1 is a multifunctional regulator that can, on one hand, antagonise the immune system in different ways and, on the other hand, promote lytic replication through interaction and stabilisation of the cellular protein hFEN1 or by transactivation of viral promoters. IE1 antagonises PML-NBs, a part of the intrinsic immune system, through
openaire +2 more sources
PLoS ONE, 2012 Laterality is a basic characteristic of the brain which is detectable early in life. Although early experiences affect laterality of the mature brain, there are no reports on their immediate neurochemical effects during neonatal life, which could provide
Androniki Raftogianni +6 more
doaj +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A visible light‐responsive polyacrylamide‐azobenzene hydrogel enables safe, reversible stiffness control for studying cell mechanobiology without harmful UV exposure. This approach reveals stem cells respond rapidly to mechanical changes, showing altered shape and protein distribution within one hour.
Aafreen Ansari +11 more
wiley +1 more source
The Equine Herpesvirus 1 Immediate-Early Protein Interacts with EAP, a Nucleolar-Ribosomal Protein
Virology, 2001 The equine herpesvirus 1 (EHV-1) immediate-early (IE) phosphoprotein is essential for the activation of transcription from viral early and late promoters and regulates transcription from its own promoter. The IE protein of 1487 amino acids contains a serine-rich tract (SRT) between residues 181 and 220.
Kimberly A. Buczynski +3 more
openaire +3 more sources
PLoS Pathogens, 2016 We used pulse-labeling with the methionine analogue homopropargylglycine (HPG) to investigate spatiotemporal aspects of protein synthesis during herpes simplex virus (HSV) infection.
Catherine Su Hui Teo +2 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Simultaneous utilization of calix[4]pyrrole‐ and crown ether‐based molecular recognition allows the construction of a high molecular weight alternating supramolecular polymer. This heat processible polymer can be used as a durable and reusable adhesive on glass and steel with temperature‐enhanced adhesion strength without the need for a solvent ...
Deniz Memis, Abdullah Aydogan
wiley +1 more source
BMC Biology, 2012 Background Efficient osteogenic differentiation is highly dependent on coordinated signals arising from growth factor signalling and mechanical forces. Bone morphogenetic proteins (BMPs) are secreted proteins that trigger Smad and non-Smad pathways and ...
Kopf Jessica +3 more
doaj +1 more source