Immediate Early Gene c-fos in the Brain: Focus on Glial Cells [PDF]
Brain Sciences, 2022 The c-fos gene was first described as a proto-oncogene responsible for the induction of bone tumors. A few decades ago, activation of the protein product c-fos was reported in the brain after seizures and other noxious stimuli.
Fernando Cruz-Mendoza +4 more
doaj +3 more sources
Influence of isoflurane on Immediate-Early Gene expression [PDF]
Frontiers in Behavioral Neuroscience, 2016 Background: Anterograde amnesia is a hallmark effect of volatile anesthetics. Isoflurane is known to affect both the translation and transcription of plasticity-associated genes required for normal memory formation in many brain regions.
Kristopher M Bunting +4 more
doaj +4 more sources
Functional correlates of immediate early gene expression in mouse visual cortex [PDF]
Peer Community Journal, 2022 During visual development, response properties of layer 2/3 neurons in visual cortex are shaped by experience. Both visual and visuomotor experience are necessary to coordinate the integration of bottom-up visual input and top-down motor-related input ...
Mahringer, David +4 more
doaj +2 more sources
Control of Immediate Early Gene Expression for Human Cytomegalovirus Reactivation [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Human cytomegalovirus (HCMV) is a beta herpesvirus that persists for life in the majority of the world's population. The persistence of HCMV in the human population is due to the exquisite ability of herpesviruses to establish a latent infection that ...
Donna Collins-McMillen +3 more
doaj +2 more sources
Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation [PDF]
Genome Biology, 2022 Background Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is known to associate with cytoplasmic polyadenylation elements (CPEs) located in the 3′ untranslated region (UTR) of specific mRNAs and assemble an activator complex promoting the ...
Fabian Poetz +5 more
doaj +2 more sources
The Lysine Demethylase KDM7A Regulates Immediate Early Genes in Neurons [PDF]
Advanced Science, 2023 Lysine demethylase KDM7A removes histone modifications H3K9me1/2 and H3K27me1/2. KDM7A plays critical roles in gene expression and contribute to biological processes including tumorigenesis, metabolism, and embryonic development.
Yifan Wang +4 more
doaj +2 more sources
Data on electroconvulsive seizure in mice, effects of anesthesia on immediate early gene expression [PDF]
Data in BriefAlthough electroconvulsive therapy (ECT) is one of the most effective treatments for severe mood and psychotic disorders, the mechanisms underlying its therapeutic effects remain unknown. Electroconvulsive stimulation (ECS), the animal model for ECT, can
A.B. Ozols +8 more
doaj +2 more sources
Visualization of odor-induced neuronal activity by immediate early gene expression
BMC Neuroscience, 2012 Background Sensitive detection of sensory-evoked neuronal activation is a key to mechanistic understanding of brain functions. Since immediate early genes (IEGs) are readily induced in the brain by environmental changes, tracing IEG expression provides a
Bepari Asim K +4 more
doaj +2 more sources
Somatodendritic expression of an immediate early gene is regulated by synaptic activity.
Proceedings of the National Academy of Sciences of the United States of America, 1995 Trans-synaptic activation of gene expression is linked to long-term plastic adaptations in the nervous system. To examine the molecular program induced by synaptic activity, we have employed molecular cloning techniques to identify an immediate early ...
Wolfgang Link +6 more
openalex +3 more sources
LINC00473 as an Immediate Early Gene under the Control of the EGR1 Transcription Factor [PDF]
Non-Coding RNA, 2020 Immediate early genes play an essential role in cellular responses to different stimuli. Many of them are transcription factors that regulate the secondary response gene expression. Non-coding RNAs may also be involved in this regulatory cascade. In fact,
Vincenza Aliperti +3 more
doaj +2 more sources