Results 11 to 20 of about 1,253,551 (390)

Acute Stress Enhances Epigenetic Modifications But Does Not Affect the Constitutive Binding of pCREB to Immediate-Early Gene Promoters in the Rat Hippocampus

Frontiers in Molecular Neuroscience, 2017
The immediate early genes (IEGs) c-Fos and Egr-1 are rapidly and transiently induced in sparse neurons within the hippocampus after exposure to an acute stressor.
Sylvia D. Carter, Karen R. Mifsud, Johannes M. H. M. Reul   +2 more
doaj   +2 more sources

A whole-brain analysis of functional connectivity and immediate early gene expression reveals functional network shifts after operant learning

NeuroImage
Previous studies of operant learning have addressed neuronal activities and network changes in specific brain areas, such as the striatum, sensorimotor cortex, prefrontal/orbitofrontal cortices, and hippocampus.
Kazumi Kasahara, Keigo Hikishima, Mariko Nakata, Tomokazu Tsurugizawa, Noriyuki Higo, Kenji Doya   +5 more
doaj   +2 more sources

MECHANISMS OF IMMEDIATE-EARLY GENES ACTIVATION

Медицинский вестник Юга России, 2016
In our article, we focus on molecular mechanisms of immediately early genes expression. We discuss extracellular signals that are transduced into the nucleus through a variety of signaling mechanisms to elicit changes in patterns of immediately early ...
P. P. Polyakov, A. S. Lipatova, A. H. Kade   +2 more
doaj   +3 more sources

Immediate early gene fingerprints of multi-component behaviour. [PDF]

Sci Rep, 2020
AbstractThe ability to execute different responses in an expedient temporal order is central for efficient goal-directed actions and often referred to as multi-component behaviour. However, the underlying neural mechanisms on a cellular level remain unclear.
Rook N, Letzner S, Packheiser J, Güntürkün O, Beste C.   +4 more
europepmc   +5 more sources

Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress. [PDF]

Cell Rep, 2020
Murai J, Zhang H, Pongor L, Tang SW, Jo U, Moribe F, Ma Y, Tomita M, Pommier Y.   +8 more
europepmc   +2 more sources

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus [PDF]

Cell, 1985
A strong transcription enhancer was identified in the genomic DNA (235 kb) of human cytomegalovirus (HCMV), a ubiquitous and severe pathogen of the herpesvirus group.
M. Boshart, F. Weber, G. Jahn, Karoline Dorsch-H⇒ler, B. Fleckenstein, W. Schaffner   +5 more
semanticscholar   +3 more sources

Shared and distinct brain regions targeted for immediate early gene expression by ketamine and psilocybin

bioRxiv, 2022
Background Psilocybin is a psychedelic with therapeutic potential. While there is growing evidence that psilocybin exerts its beneficial effects through enhancing neural plasticity, the exact brain regions involved are not completely understood ...
Pasha A Davoudian, Ling-Xiao Shao, A. Kwan   +2 more
semanticscholar   +1 more source

IL-3-Induced Immediate Expression of c-fos and c-jun Is Modulated by the IKK2-JNK Axis

Cells, 2022
Interleukin (IL)-3 is a pleiotropic cytokine that regulates the survival, proliferation, and differentiation of hematopoietic cells. The binding of IL-3 to its receptor activates intracellular signaling, inducing transcription of immediate early genes ...
Hirotaka Fujita, Toshitsugu Fujita, Hodaka Fujii   +2 more
doaj   +1 more source

The ORF45 Protein of Kaposi’s Sarcoma-Associated Herpesvirus and Its Critical Role in the Viral Life Cycle

Viruses, 2022
Kaposi’s sarcoma-associated herpesvirus (KSHV) protein ORF45 is a virion-associated tegument protein that is unique to the gammaherpesvirus family. Generation of KSHV ORF45-knockout mutants and their subsequent functional analyses have permitted a better
Natalie Atyeo, Bernadett Papp
doaj   +1 more source

Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function

Viruses, 2020
The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections cause severe disease in immunosuppressed patients and congenital defects in ...
C. Adamson, M. Nevels
semanticscholar   +1 more source