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Immediate-early genes, kindling and long-term potentiation
Neuroscience & Biobehavioral Reviews, 1989The mechanism(s) by which long-term changes are induced and maintained in the nervous system are poorly understood. Kindling is an example of a permanent change in brain function that results from repeated elicitation of seizures. Recently, a class of genes called "immediate-early genes" that were previously thought to be only involved in cell division,
M, Dragunow +4 more
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Immediate-early genes and chronic pain
APS Journal, 1994T he hypothesis presented by Zimmerman and Herdegen is an intriguing one. Both clinical and experimental evidence suggest that prolonged nociceptive input or neural injury may produce chronic foci of hyperactivity within the central nervous system (CNS). These foci may be responsible for the development of chronic pain. If this is indeed the case, such
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Immediate-early genes and opioid peptides
1995Cellular stimulation causes the rapid appearance of proteins in the nucleus which function as signal-regulated transcription factors converting membrane events into long-term changes in gene expression. These transcription factors are the products of a variety of immediate early genes (IEG).
J. Kraus, B. Bacher, X. Wang, V. Höllt
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Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles
Nature Neuroscience, 1999J. Guzowski +3 more
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Immediate-early gene expression in the barrel cortex
Somatosensory & Motor Research, 2006Since their detection in the early 1980s immediate-early genes (most of them being inducible transcription factors) have been regarded as molecular keys to the orchestration of late-effector genes that ultimately would enable functional and structural adaptation of the brain to changing external and internal demands.
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Immediate-early genes: ten years on
Trends in Neurosciences, 1995J I, Morgan, T, Curran
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Molecular interpretation of ERK signal duration by immediate early gene products
Nature Cell Biology, 2002Leon O. Murphy +4 more
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