The Lysine Demethylase KDM7A Regulates Immediate Early Genes in Neurons [PDF]
Advanced Science, 2023 Lysine demethylase KDM7A removes histone modifications H3K9me1/2 and H3K27me1/2. KDM7A plays critical roles in gene expression and contribute to biological processes including tumorigenesis, metabolism, and embryonic development.
Yifan Wang +4 more
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Retrosplenial cortex in spatial memory: focus on immediate early genes mapping [PDF]
Molecular Brain, 2021 The ability to form, retrieve and update autobiographical memories is one of the most fascinating features of human behavior. Spatial memory, the ability to remember the layout of the external environment and to navigate within its boundaries, is closely
Edyta Balcerek +2 more
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Identification of the Immediate-Early Genes of Cyprinid Herpesvirus 2 [PDF]
Viruses, 2020 Cyprinid herpesvirus 2 (CyHV-2), which infects goldfish and crucian carp causing high mortality, is an emerging viral pathogen worldwide. The genome of CyHV-2 is large and comprises double-stranded DNA, including several genes similar to cyprinid ...
Ruizhe Tang +4 more
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ATRX Promotes Transcription Initiation of HSV-1 Immediate Early Genes During Early Lytic Infection [PDF]
VirusesHerpes simplex virus 1 (HSV-1) transcribes its genome using host RNA polymerase II (Pol II) in a temporally regulated cascade. We previously proposed a model of Transient Immediate Early gene Mediated Repression (TIEMR), in which early repression of ...
Laura E. M. Dunn +2 more
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Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus [PDF]
CellsBrain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the formation and elimination of synapses.
Pavel P. Tregub +7 more
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Dissecting Neuronal Activation on a Brain-Wide Scale With Immediate Early Genes [PDF]
Frontiers in Neuroscience, 2020 Visualizing neuronal activation on a brain-wide scale yet with cellular resolution is a fundamental technical challenge for neuroscience. This would enable analyzing how different neuronal circuits are disrupted in pathology and how they could be rescued
Alessandra Franceschini +8 more
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Synapse development organized by neuronal activity-regulated immediate-early genes [PDF]
Experimental and Molecular Medicine, 2018 Neuroscience: Environment-driven gene activation Immediate-early genes (IEGs), genes that are rapidly and transiently activated by cellular stimuli, regulate the interactions between neurons and key brain functions.
Seungjoon Kim, Hyeonho Kim, Ji Won Um
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Multiplexed detection of nuclear immediate early gene expression reveals hippocampal neuronal subpopulations that engage in the acquisition and updating of spatial experience [PDF]
Frontiers in Integrative NeuroscienceAcquired spatial representations are not static. Each re-exposure to the spatial environment stimulates retrieval of the stored experience followed by information re-encoding, including updating if the environment has changed.
Thu-Huong Hoang, Denise Manahan-Vaughan
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Editorial: The Role of Immediate Early Genes in Neuropsychiatric Illness [PDF]
Frontiers in Behavioral Neuroscience, 2020 Amelia L. Gallitano
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Treadmill Exercise as a Preventive Measure Against Age-Related Anxiety and Social Behavioral Disorders in Rats: When Is It Worth Starting? [PDF]
Annals of Rehabilitation Medicine, 2022 Objective To determine the appropriate time points to start regular exercise which could reduce age-related anxiety and impaired social behavior. Methods For this study, 8-week-old male Wistar rats were divided into three groups: no exercise (NoEX ...
Satoru Taguchi +5 more
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