Results 301 to 310 of about 450,843 (345)
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Immediate-early genes in nociception
1995Cellular immediate-early genes (IEGs) share a close structural homology with some viral oncogenes. In the eukaryotic genome these counterparts of oncogenes have been termed proto-oncogenes. Recent advances in cellular biology have identified the activation and deactivation of IEGs as molecular mechanisms to control regulated and deregulated growth ...
Tölle, T. +3 more
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Expression of Immediate Early Genes in Sensory Ganglia
Neurochemical Research, 2001C-Jun and c-Fos belong to the family of immediate early genes. Apart from their role as transcription factors, a basal expression was shown for them in central nervous system tissues. The expression of c-Jun and c-Fos in sensory ganglia of guinea pig, rat and murine sensory ganglia was examined under normal, unstimulated conditions by quantitative ...
Groneberg, David A. +5 more
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Activation of immediate early genes after acute stress
NeuroReport, 1991We used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and ...
S S, Schreiber +3 more
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Kaposi's sarcoma-associated herpesvirus immediate early gene activity
Frontiers in Bioscience, 2004KSHV is the causative agent of three human proliferative disorders: Kaposi s sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Herpesvirus gene expression and viral replication is a complex, tightly regulated process involving latent, immediate early, early, and late viral gene transcription.
Vincent, Lacoste +3 more
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Immediate-early genes — how immediate and why early?
1995The prerequisite for multicellularity is the effective integration of component cells in the formation and maintenance of complex tissue architectures. As a consequence, metazoan cells require sophisticated molecular machinery with which to communicate with their environment.
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Immediate-early genes, neuronal plasticity, and memory
Biochemistry and Cell Biology, 1992The demonstration that the immediate-early gene c-fos is rapidly and transiently expressed in brain following a variety of manipulations has led to intense study of these genes to determine what physiological role they play. The very wide range of stimuli which lead to induction of immediate-early genes (IEGs) in the brain has raised concerns for the ...
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Immediate-early genes induced by antigen receptor stimulation
Current Opinion in Immunology, 1995Immediate early genes induced by triggering of the TCR frequently encode proteins that act in signal transduction cascades. Recent advances concerning several immediate-early proteins have been made, including signal-induced regulation of NF-kappa B by I kappa-B, the role of Nur77 in T-cell selection and apoptosis, and the function of PAC-1 in ...
K, Kelly, U, Siebenlist
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Immediate-early genes, kindling and long-term potentiation
Neuroscience & Biobehavioral Reviews, 1989The mechanism(s) by which long-term changes are induced and maintained in the nervous system are poorly understood. Kindling is an example of a permanent change in brain function that results from repeated elicitation of seizures. Recently, a class of genes called "immediate-early genes" that were previously thought to be only involved in cell division,
M, Dragunow +4 more
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Immediate-early genes and chronic pain
APS Journal, 1994T he hypothesis presented by Zimmerman and Herdegen is an intriguing one. Both clinical and experimental evidence suggest that prolonged nociceptive input or neural injury may produce chronic foci of hyperactivity within the central nervous system (CNS). These foci may be responsible for the development of chronic pain. If this is indeed the case, such
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Immediate-early genes and opioid peptides
1995Cellular stimulation causes the rapid appearance of proteins in the nucleus which function as signal-regulated transcription factors converting membrane events into long-term changes in gene expression. These transcription factors are the products of a variety of immediate early genes (IEG).
J. Kraus, B. Bacher, X. Wang, V. Höllt
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