The Transcriptional Corepressor NAB2 Inhibits NGF-induced Differentiation of PC12 Cells [PDF]
, 1998 The PC12 pheochromocytoma cell line responds to NGF by undergoing growth arrest and proceeding to differentiate toward a neuronal phenotype. Among the early genetic events triggered by NGF in PC12 cells are the rapid activation of the zinc finger ...
Davidson, Norman +5 more
core +2 more sources
Frontiers in Neuroscience, 2020 Patterns of neuronal activity that induce synaptic plasticity and memory storage activate kinase cascades in neurons that are thought to be part of the mechanism for synaptic modification.
Minoru Fujiki +6 more
doaj +1 more source
Stressor controllability modulates the stress response in fish
BMC Neuroscience, 2021 Background In humans the stress response is known to be modulated to a great extent by psychological factors, particularly by the predictability and the perceived control that the subject has of the stressor.
Marco Cerqueira +9 more
doaj +1 more source
Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease. [PDF]
, 2017 Molecular mechanisms underlying development of acute pneumonitis and/or late fibrosis following thoracic irradiation remain poorly understood. Here, we hypothesize that heterogeneity in disease progression and phenotypic expression of radiation-induced ...
Baye, Fitsum +8 more
core +4 more sources
Frontiers in Behavioral Neuroscience, 2013 Episodic memory reflects the capacity to recollect what, where and when a specific event happened in an integrative manner. Animal studies have suggested that the medial temporal lobe and the medial pre-frontal cortex are important for episodic-like ...
Flávio F Barbosa +7 more
doaj +1 more source
The Core Histone-binding Region of the Murine Cytomegalovirus 89K Immediate Early Protein [PDF]
, 1991 The gene regulatory immediate early protein, pp89, of murine cytomegalovirus interacts with both DNA-associated and isolated histones in vitro. We characterized the histone-binding region of pp89 and its cellular localization during cell division to ...
Bühler, Bernhard +3 more
core +1 more source
Striatal NELF-mediated RNA polymerase II stalling controls l-dopa induced dyskinesia
Neurobiology of Disease, 2016 Long-term l-3,4-dihydroxyphenylalanine (l-Dopa) treatment in Parkinson's disease leads to involuntary movements called dyskinesia, notably through an overexpression of immediate-early genes (IEG).
Matthieu F. Bastide +3 more
doaj +1 more source
Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment [PDF]
, 1992 Selective expression of murine cytomegalovirus (MCMV) immediate-early (IE) genes leads to the presentation by the major histocompatibility complex (MHC) class I molecule L a of a peptide derived from MCMV IE protein pp89 (Reddehase, M. J., J.
Del Val, Margarita +6 more
core +2 more sources
Immediate-Early Genes and Synaptic Function
Neurobiology of Learning and Memory, 1998 Classical studies have demonstrated a role for protein synthesis in long-term memory. The focus of our research is to identify the proteins that are essential for memory and to discover how they contribute to activity-dependent neuronal plasticity. We have developed whole-animal models that maximize the induction of activity-dependent genes and have ...
A, Lanahan, P, Worley
openaire +2 more sources
Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease [PDF]
, 2018 Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes.
Bai, Ying +10 more
core +1 more source