Results 51 to 60 of about 450,843 (345)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Immediate early splicing controls translation in activated T-cells and is mediated by hnRNPC2 phosphorylation

The EMBO Journal
The fast and transient induction of immediate early genes orchestrates the cellular response to various stimuli. These stimuli trigger phosphorylation cascades that promote immediate early gene transcription independent of de novo protein synthesis. Here
Mateusz Dróżdż, Luíza Zuvanov, Gopika Sasikumar, Debojit Bose, Franziska Bruening, Maria S Robles, Marco Preußner, Markus Wahl, Florian Heyd   +8 more
doaj   +1 more source

Brain-wide neuronal activation and functional connectivity are modulated by prior exposure to repetitive learning episodes

Frontiers in Behavioral Neuroscience, 2022
Memory storage and retrieval are shaped by past experiences. Prior learning and memory episodes have numerous impacts on brain structure from micro to macroscale.
Dylan J. Terstege, Isabella M. Durante, Jonathan R. Epp   +2 more
doaj   +1 more source

Characterization of the murine cytomegalovirus early transcription unit e1 that is induced by immediate-early proteins [PDF]

, 1990
The regulation of murine cytomegalovirus early (E) gene expression was studied in the cell line B25, which is stably transfected with the immediate-early ie1/ie3 gene complex.
Bühler, Bernhard, Keil, Günther M., Koszinowski, Ulrich H., Weiland, Frank   +3 more
core   +1 more source

Cognitive appraisal of environmental stimuli induces emotion-like states in fish [PDF]

, 2017
The occurrence of emotions in non-human animals has been the focus of debate over the years. Recently, an interest in expanding this debate to non-tetrapod vertebrates and to invertebrates has emerged. Within vertebrates, the study of emotion in teleosts
A Zayed, AI Faustino, D Nettle, DJ Anderson, ES Paul, G Leal, G Liebsch, GJ Quirk, J Ganz, J Ganz, J LeDoux, JA Russell, JA Russell, JE LeDoux, JE Ploski, JF Lopez-Olmeda, JM McNamara, KC Berridge, KC Berridge, KP Maruska, L Galhardo, LA O’Connell, LF Barrett, M Mendl, MA Vindas, MA Vindas, P Ekman, PC Trimmer, R Landgraf, RJ Dolan, S Millot, S Millot, SD Cardoso, SE Wendelaar Bonga, T Brosch, T Kawashima, TP Sheehan, TW Fawcett, WT Gibson, X Sun, Y Benjamini, Y Lin   +41 more
core   +5 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

MSK-Mediated Phosphorylation of Histone H3 Ser28 Couples MAPK Signalling with Early Gene Induction and Cardiac Hypertrophy

Cells, 2022
Heart failure is a leading cause of death that develops subsequent to deleterious hypertrophic cardiac remodelling. MAPK pathways play a key role in coordinating the induction of gene expression during hypertrophy.
Emma L. Robinson, Faye M. Drawnel, Saher Mehdi, Caroline R. Archer, Wei Liu, Hanneke Okkenhaug, Kanar Alkass, Jan Magnus Aronsen, Chandan K. Nagaraju, Ivar Sjaastad, Karin R. Sipido, Olaf Bergmann, J. Simon C. Arthur, Xin Wang, H. Llewelyn Roderick   +14 more
doaj   +1 more source

Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisons. [PDF]

, 2016
Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can have damaging, off-target effects on neurons leading to cognitive, sensory and motor deficits.
Butchbach, Matthew E.R., Gentillon, Cinsley, Harris, Ashlee W., Holbrook, Jennifer, Lumpkin, Casey J., McCahan, Suzanne M., Rossi, Sharyn L., Wang, Wenlan   +7 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Probing the roles of developmentally active neurons, in early-life adversity induced disruptions of adult behaviors

Frontiers in Neuroscience
Early life adversity (ELA) is associated with subsequent mental health problems, and animal studies provide evidence for a causal role of ELA in the risk for mental illness, including persistent brain changes at molecular, cellular, network and ...
Ryan Weber, Ali Mortazavi, Tallie Z. Baram, Tallie Z. Baram, Tallie Z. Baram, Amalia Floriou-Servou   +5 more
doaj   +1 more source