Results 81 to 90 of about 450,843 (345)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Distinct epigenetic and gene expression changes in rat hippocampal neurons after Morris water maze training

Frontiers in Behavioral Neuroscience, 2015
Gene transcription and translation in the hippocampus is of critical importance in hippocampus-dependent memory formation, including during Morris water maze (MWM) learning.
Sylvia D. eCarter, Karen R. eMifsud, Johannes M.H.M. eReul   +2 more
doaj   +1 more source

Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation

Genome Biology, 2022
Background Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is known to associate with cytoplasmic polyadenylation elements (CPEs) located in the 3′ untranslated region (UTR) of specific mRNAs and assemble an activator complex promoting the ...
Fabian Poetz, Svetlana Lebedeva, Johanna Schott, Doris Lindner, Uwe Ohler, Georg Stoecklin   +5 more
doaj   +1 more source

The Biosemiotic Approach in Biology : Theoretical Bases and Applied Models [PDF]

, 2011
Biosemiotics is a growing fi eld that investigates semiotic processes in the living realm in an attempt to combine the fi ndings of the biological sciences and semiotics. Semiotic processes are more or less what biologists have typically referred to as “
El-Hani, Charbel, Emmeche, Claus, Kull, Kalevi, Queiroz, Joao   +3 more
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Time course of immediate early gene protein expression in the spinal cord following conditioning stimulation of the sciatic nerve in rats. [PDF]

PLoS ONE, 2015
Long-term potentiation induced by conditioning electrical stimulation of afferent fibers is a widely studied form of synaptic plasticity in the brain and the spinal cord.
Ognjen Bojovic, Debabrata Panja, Margarethe Bittins, Clive R Bramham, Arne Tjølsen   +4 more
doaj   +1 more source

Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress [PDF]

, 2012
When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and proteins are damaged and cellular transcription networks are activated.
Abdulkadir, Abdulkadir, Aggeli, Arsenian, Banks, Baron, Bedadala, Bedard, Bjelakovic, Bjelakovic, Bonventre, Brand, Calogero, Cao, Cao, Chang, Chen, Christy, Christy, Cramer, Datta, Dixit, Dixit, Dyson, Dyson, Eidelman, Elisabeth Deindl, Eto, Eto, Fahmy, Fahmy, Feldman, Forsberg, Förstermann, Gao, Gashler, Hallahan, Halliwell, Harja, Harman, Harrison, Hasan, Hasan, Hebert, Heo, Hill, Hirata, Huang, Irani, Iyoda, Izumi, Judith-Irina Pagel, Katsarou, Kawamura, Khachigian, Khachigian, Konishi, Lee, Liao, Lim, Lukac, Marais, Meira, Nishi, Nose, Nose, Nozik-Grayck, Ohba, Ouellette, Pagel, Paron, Pavletich, Peskin, Pines, Preston, Radisky, Sakamoto, Sattler, Schwachtgen, Sies, Sies, Stuart, Sudenga, Tell, Tell, Tell, Tell, Terashima, Treisman, Tsai-Morris, Vickers, Vivekananthan, Wang, Whitmarsh, Yan, Yan, Yang, Yang, Ye, Yu   +99 more
core   +2 more sources

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Comparative Analysis of Muscle Hypertrophy Models Reveals Divergent Gene Transcription Profiles and Points to Translational Regulation of Muscle Growth through Increased mTOR Signaling

Frontiers in Physiology, 2017
Skeletal muscle mass is a result of the balance between protein breakdown and protein synthesis. It has been shown that multiple conditions of muscle atrophy are characterized by the common regulation of a specific set of genes, termed atrogenes.
Marcelo G. Pereira, Marcelo G. Pereira, Kenneth A. Dyar, Kenneth A. Dyar, Leonardo Nogara, Leonardo Nogara, Francesca Solagna, Manuela Marabita, Martina Baraldo, Martina Baraldo, Francesco Chemello, Elena Germinario, Vanina Romanello, Vanina Romanello, Hendrik Nolte, Bert Blaauw, Bert Blaauw   +16 more
doaj   +1 more source

An HIV feedback resistor: auto-regulatory circuit deactivator and noise buffer. [PDF]

, 2006
Animal viruses (e.g., lentiviruses and herpesviruses) use transcriptional positive feedback (i.e., transactivation) to regulate their gene expression.
Shenk, Thomas, Weinberger, Leor S
core   +4 more sources