Results 41 to 50 of about 11,893,583 (290)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Full-Scale Simulation of the Fluid–Particle Interaction Under Magnetic Field Based on IIM–IBM–LBM Coupling Method

open access: yesFrontiers in Materials, 2022
In this article, a full-scale computational model for fluid–particle interaction under a magnetic field is developed. In this model, the fluid field is solved by the lattice Boltzmann method, and the hydrodynamic force acting on the particle is computed ...
Wei Peng   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Lattice Boltzmann method and immersed boundary method for the simulation of viscous fluid flows [PDF]

open access: yes, 2018
Most realistic fluid flow problems are characterised by high Reynolds numbers and complex boundaries. Over the last ten years, immersed boundary methods (IBM) that are able to cope with realistic geometries have been applied to Lattice- Boltzmann ...
Falagkaris, Emmanouil
core   +3 more sources

Numerical Investigation of Freely Falling Objects Using Direct-Forcing Immersed Boundary Method

open access: yesMathematics, 2020
The fluid-structure interaction of solid objects freely falling in a Newtonian fluid was investigated numerically by direct-forcing immersed boundary (DFIB) method. The Navier–Stokes equations are coupled with equations of motion through virtual force to
Cheng-Shu You   +3 more
doaj   +1 more source

A Revisit of Implicit Monolithic Algorithms for Compressible Solids Immersed Inside a Compressible Liquid

open access: yesFluids, 2021
With the development of mature Computational Fluid Dynamics (CFD) tools for fluids (air and liquid) and Finite Element Methods (FEM) for solids and structures, many approaches have been proposed to tackle the so-called Fluid–Structure Interaction or ...
Sheldon Wang
doaj   +1 more source

A fine-grained parallelization of the immersed boundary method

open access: yesThe International Journal of High Performance Computing Applications, 2022
We present new algorithms for the parallelization of Eulerian–Lagrangian interaction operations in the immersed boundary method. Our algorithms rely on two well-studied parallel primitives: key-value sort and segmented reduce. The use of these parallel primitives allows us to implement our algorithms on both graphics processing units (GPUs) and on ...
Andrew T. Kassen   +2 more
openaire   +3 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

An improved direct forcing immersed boundary method for floating body simulations in waves

open access: yesApplied Ocean Research
This paper introduces a novel direct forcing immersed boundary method tailored to simulate nonlinear interactions between ocean waves and arbitrarily complex free-floating structures.
Ahmet Soydan, Widar W. Wang, Hans Bihs
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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