Results 41 to 50 of about 898,111 (319)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Examining Disequilibrium in an Immersion Experience [PDF]

, 2013
This study examines the disequilibrium raised by a cultural immersion experience, using the structure of White racial identity development, in an effort to better scaffold the immersion experience in the future.
Addleman, Rebecca A., Brazo, Carol J., Harris, Genevieve   +2 more
core   +1 more source

Immersion microscopy based on photonic crystal materials

, 2005
Theoretical model of the enhanced optical resolution of the surface plasmon immersion microscope is developed, which is based on the optics of surface plasmon Bloch waves in the tightly bound approximation.
Davis, Christopher C., Elliott, Jill, Smolyaninov, Igor I., Wurtz, G., Zayats, Anatoly V.   +4 more
core   +1 more source

Phase separation processes in polymer solutions in relation to membrane formation [PDF]

, 1996
This review covers new experimental and theoretical physical research related to the formation of polymeric membranes by phase separation of a polymer solution, and to the morphology of these membranes.
Berg, J.W.A. van den, Dijkstra, P.J., Feijen, J., Witte, P. van de   +3 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Machine learning-based insights on the structural variations found in the C-terminal domains of differing human papillomavirus E6 and E7 protein models across geography, variants, and risk type

In Silico Research in Biomedicine
Human papillomavirus (HPV) are nonenveloped DNA viruses belonging to the Papillomaviridae family and, during HPV infection, the first viral genes expressed are the E6 and E7 oncogenes with the C-terminal domain mainly involved with oncogenicity.
Marni E. Cueno, Haruka Tamura, Felix Sugiyama, Kenichi Imai   +3 more
doaj   +1 more source

The Lived Experience of Cultural Immersion [PDF]

, 2013
This article presents the findings of a grounded theory study of 3 graduate students\u27 lived experience of cultural immersion. Results indicated that participants experienced 3 phases (goal setting, interaction, and evaluation) and 4 themes (bias ...
Avrus, Elaine M., Bonham, Erica J., Cook, Jennifer, Hipolito-Delgado, Carlos P.   +3 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Application of Virtual Reality in Computer Science Education: A Systemic Review Based on Bibliometric and Content Analysis Methods

Education Sciences, 2021
This study investigated the role of virtual reality (VR) in computer science (CS) education over the last 10 years by conducting a bibliometric and content analysis of articles related to the use of VR in CS education.
Friday Joseph Agbo, Ismaila Temitayo Sanusi, Solomon Sunday Oyelere, Jarkko Suhonen   +3 more
doaj   +1 more source

Constructing graphs with no immersion of large complete graphs [PDF]

, 2012
In 1989, Lescure and Meyniel proved, for $d=5, 6$, that every $d$-chromatic graph contains an immersion of $K_d$, and in 2003 Abu-Khzam and Langston conjectured that this holds for all $d$.
E. Heenehan, Karen L. Collins, Megan
core