Results 61 to 70 of about 21,252 (310)

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal   +3 more
wiley   +1 more source

Survival Outcomes of Gemcitabine–Cisplatin–S‐1 Versus Gemcitabine–Cisplatin in Unresectable Biliary Tract Cancer: A Multicenter Retrospective Study With a Focus on Conversion Surgery

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
In this multicenter retrospective study conducted by the Biliary Tract Club, we compared survival outcomes between gemcitabine–cisplatin–S‐1 (GCS) and gemcitabine–cisplatin (GC) in patients with unresectable biliary tract cancer, with a particular focus on conversion surgery. GCS was associated with longer overall and progression‐free survival compared
Hisashi Kosaka   +27 more
wiley   +1 more source

The Immortality of the Soul in the First Half of Phaedo

open access: yesPlato
In the Phaedo, Plato presents a dual conception of the soul’s fate “ one for the philosophers, whose purified souls ascend toward the Forms (80e-81a, 82c-84b, 114c-115a), and one for non-philosophers, whose impure souls remain trapped in the cycle of ...
Minxing Huang
doaj   +1 more source

Живое универсальное разумное существо, остоящее из сознания и тела-трансформера [PDF]

open access: yesФилософия и космология, 2012
The problem of the survival and development of Homo sapiens put the need for a radical extension of human life on the agenda in the XXI century. Among the many possible scenarios, there is extreme radical scenario of human transformation and the creation
Кричевский С. В.
doaj  

Transformationen der Kantischen Postulatenlehre im „Cambridge Pragmatism“ (Charles S. Peirce, William James, Josiah Royce)

open access: yesКантовский сборник, 2021
The “Cambridge pragmatists”, Charles S. Peirce, William James and Josiah Royce, are at least in two respects significantly indebted to Kant: first, as von Kempski, Apel and Murphey have shown, with regard to the epistemological issues investigated in ...
Ludwig Nagl
doaj   +1 more source

Determinants of Long‐Term Benefit From High Dose Melphalan With Autologous Stem Cell Transplant in AL Amyloidosis

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT High dose melphalan (HDM) with autologous stem cell transplant is an established treatment for systemic light chain amyloidosis, but its incremental benefit in the era of effective standard intensity therapy is unknown. We retrospectively analyzed 475 transplant‐eligible patients who completed standard intensity treatment with or without HDM ...
Maximilian J. Steinhardt   +23 more
wiley   +1 more source

“Little” Immortality: Immortological Theme in the Internet Microformats

open access: yesCorpus Mundi
This article correlates in content with the previous article in the journal. Internet microformats (short stories, gifs, pics, memes, demotivators, etc.) have a short life compared to “monumental” content, but are characterized by a high speed of ...
Artur A. Dydrov, Milena S. Vizgina
doaj   +1 more source

Moldova – topos de legendă și nemurire

open access: yesRecherches, 2013
Ramona Blajan Rusu is the author of a monography about C. V. Gheorghiu. She defended her thesis at Alba Iulia university in 2012 (director of research Constantin Cublesan). The main subjects are: – C. V.
Ramona Blajan
doaj   +1 more source

Therapeutic Outcomes in VEXAS Syndrome: A Multicenter Comparative Cohort of Allogeneic Hematopoietic Stem Cell Transplantation and Hypomethylating Agents

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Hypomethylating agents (HMA) and allogeneic hematopoietic stem cell transplantation (alloHSCT) have both demonstrated remissions in VEXAS; however, comparative data is lacking. We conducted a multicenter, retrospective analysis of 66 patients diagnosed with VEXAS syndrome treated with HMA (n = 35) or alloHSCT (n = 31). Baseline characteristics
Saubia Fathima   +48 more
wiley   +1 more source

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