Results 131 to 140 of about 6,308 (185)

Immune-Mediated Necrotizing Myopathies: Current Landscape

Current Neurology and Neuroscience Reports
Immune-mediated necrotizing myopathy (IMNM), characterized by acute or subacute onset, severe weakness, and elevated creatine kinase levels, poses diagnostic and therapeutic challenges. This article provides a succinct overview of IMNM, including clinical features, diagnostic strategies, and treatment approaches.Recent insights highlight the different ...
Christoforos, Koumas, Francesco, Michelassi   +1 more
openaire   +2 more sources

Steroid-Responsive Myopathy: Immune-Mediated Necrotizing Myopathy or Polymyositis Without Inflammation?

Journal of Clinical Neuromuscular Disease, 2008
ABSTRACT Objective: To describe the clinical course and steroid responsiveness of a patient with subacute proximal symmetric weakness, very high serum creatine kinase activity, and myopathic pattern with fibrillations in the electromyogram, whose muscle biopsy showed necrotizing myopathy, with practically no ...
Menachem, Sadeh, Ron, Dabby
openaire   +2 more sources

The Characteristics of Imaging Patterns on Whole-body Magnetic Resonance Imaging of Anti-signal Recognition Particle Antibody-positive Immune-mediated Necrotizing Myopathy.

Acta neurologica Taiwanica
BACKGROUND Immune-mediated necrotizing myopathy (IMNM) is a rapidly progressive subtype of inflammatory myositis that can be managed with early immunotherapy.
Ya-Yuan Hou, Wei-Chin Huang, Chi-Ren Huang, Shun-Sheng Chen, Nai-Wen Tsai, Shu-Fang Chen   +5 more
semanticscholar   +1 more source

Immune-Mediated Necrotizing Myopathy (IMNM)

2019
Immune-mediated necrotizing myopathy (IMNM) is a distinct subset of the idiopathic inflammatory myopathies, characterized by proximal muscle weakness and muscle atrophy, markedly elevated CK levels, and myocyte necrosis with minimal inflammatory infiltrate on muscle biopsy.
Brittany Adler, Lisa Christopher-Stine
openaire   +1 more source

Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins

Rheumato
Statins are effective drugs for lowering cholesterol and reducing cardiovascular risk. Rarely, they can trigger autoimmune myopathies like immune-mediated necrotizing myopathy (IMNM), associated with anti-HMGCR antibodies.
Luis Angel Montero Furelos, Clara Fernandez Peña, Beatriz San Millan Tejedor   +2 more
semanticscholar   +1 more source

Efgartigimod restores muscle function in a humanized mouse model of immune-mediated necrotizing myopathy.

Rheumatology, 2023
OBJECTIVE Immune-mediated necrotizing myopathies (IMNMs) are severe forms of myositis often associated with pathogenic anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies (aAbs).
Sarah Julien, Bas van der Woning, Leentje De Ceuninck, Emma Briand, T. Jaworski, Gaëlle Roussel, Rachid Zoubaïri, Y. Allenbach, O. Benveniste, L. Drouot, O. Boyer   +10 more
semanticscholar   +1 more source

Increased prevalence and incidence of statin-associated immune-mediated necrotizing myopathy in Native Americans.

Rheumatology
OBJECTIVES Statin-associated immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy (IIM) associated with anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR) antibodies.
Tam N Dinh, Evelyn E Inga, Yvonne M Waters, Janell Francisco, Krystle L Tapia, Maheswari Muruganandam, N. S. Emil, Frank X. O’Sullivan, Wilmer L Sibbitt   +8 more
semanticscholar   +1 more source

Atypical Electrodiagnostic Findings in a Patient with Immune-Mediated Necrotizing Myopathy: A Case Study

Journal of Clinical Electrophysiology and Wound Management
Autoimmune Necrotizing Myositis (NAM)/Immune-Mediated Necrotizing Myositis (IMNM), a progressive myopathy, lacks skin lesions and exhibits unique pathologic traits.
Nancy S. Mansell, Ryan Boggs
semanticscholar   +1 more source

Anti-SRP Immune-Mediated Necrotizing Myopathy and Recent Cytomegalovirus Infection: A Case Report

International Journal of Innovative Research in Medical Science
Anti-signal recognition particle immune-mediated necrotizing myopathy (IMNM-SRP) is a rare, severe form of idiopathic inflammatory myopathy (IIM), marked by proximal muscle weakness, elevated creatine kinase levels, and significant muscle necrosis.
Beatriz Sampaio, Felisbela Gomes, João Teixeira, Mafalda Leal, Maria Rebelo   +4 more
semanticscholar   +1 more source

Statin-Associated Immune-Mediated Necrotizing Myopathy: A Case Report

International Journal of Physiatry
Statins are a widely used class of drugs that have been found to be safe and effective in treating hypercholesterolemia. Statin-associated muscle symptoms (SAMS) are a clinical spectrum defined as muscle pain, discomfort, and/or weakness with or without ...
Emily Andrews, Graham McDaniel, Haiping Mei   +2 more
semanticscholar   +1 more source