Results 101 to 110 of about 4,903,889 (243)

Update on Immune Mechanisms in Hypertension [PDF]

, 2022
Shobana Navaneethabalakrishnan, Hannah Smith, Cristina M Arenaz, Bethany L. Goodlett, Justin G McDermott, Brett M. Mitchell   +5 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Enhancing mesothelin CAR T cell therapy for pancreatic cancer with an oncolytic herpes virus boosting CAR target antigen expression

Cancer Immunology, Immunotherapy
Mesothelin (MSLN) is a prominent target antigen for CAR T cell therapy due to its extensive expression in various solid tumors, including pancreatic cancer.
Mona Alhussein Aboalela, Mohamed Abdelmoneim, Shigeru Matsumura, Ibrahim Ragab Eissa, Itzel Bustos-Villalobos, Patricia Angela Sibal, Yu Orikono, Yuhei Takido, Yoshinori Naoe, Hideki Kasuya   +9 more
doaj   +1 more source

The multiple roles of Rab9 in the endolysosomal system

Communicative & Integrative Biology, 2016
The small GTPase Rab9 has long been described as a protein that mediates endosome-to-trans-Golgi Network (TGN) transport, and specifically mannose-6-phospate receptor (MPR) recycling.
Ana Kucera, Oddmund Bakke, Cinzia Progida   +2 more
doaj   +1 more source

Haemophagocytic lymphohistiocytosis in patients treated with immune checkpoint inhibitors: analysis of WHO global database of individual case safety reports [PDF]

, 2019
Roberta Noseda, Raffaela Bertoli, Laura Müller, Alessandro Ceschi   +3 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A SARS-CoV-2 variant‑adjusted threshold of protection model for monoclonal antibody pre-exposure prophylaxis against COVID-19

Nature Communications
Clinical development of monoclonal antibodies (mAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is challenging due to rapid changes in the variant landscape. This study identified a threshold model for neutralising antibody (nAb)
Rhiannon Edge, Sam Matthews, Bahar Ahani, Anastasia A. Aksyuk, Lindsay Clegg, John L. Perez, Mark T. Esser, Lee-Jah Chang, Ian Hirsch, Tonya Villafana, John Pura, Oleg Stepanov, Katie Streicher, Tom White, Taylor S. Cohen, Dean Follmann, Peter B. Gilbert, Seth Seegobin   +17 more
doaj   +1 more source

HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD‐1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma [PDF]

, 2006
Hui Geng, Guimei Zhang, Xiao Han, Ye Yuan, Dong Li, Hui Zhang, Hui Qiu, Yufei He, Zuo‐Hua Feng   +8 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

SVR with Hybrid Chaotic Immune Algorithm for Seasonal Load Demand Forecasting [PDF]

, 2011
Wei‐Chiang Hong, Yucheng Dong, Chien-Yuan Lai, Li-Yueh Chen, Shih-Yung Wei   +4 more
openalex   +1 more source