Results 91 to 100 of about 1,503,546 (252)

Data from: Independent and interactive effects of immune activation and larval diet on adult immune function, growth and development in the greater wax moth (Galleria mellonella)

, 2021
Organisms in the wild are likely to face multiple immune challenges as well as additional ecological stressors, yet their interactive effects on immune function are poorly understood.
Krams, Indrikis,University of Tartu, Pölkki, Mari,University of Turku, Krama, Tatjana,Daugavpils University, Valtonen, Terhi M.,University of Turku, Kecko, Sanita,Daugavpils University, Kangassalo, Katariina,University of Turku, Sorvari, Jouni,University of Eastern Finland, Rantala, Markus J.,University of Turku   +7 more
core   +1 more source

Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo

, 2020
© 2020 The Authors This study explores the hypothesis that simple polymer chemistries can be used to modulate the phenotype of human immune cells. Unbiased high-throughput screening of a large library of polymer chemistries is undertaken, identifying ...
M Ilyas (5547236), ACK Teo (10018505), Morgan R Alexander (10018523), A Latif (10018508), HM Rostam (10018490), David Winkler (4602496), Andrew L Hook (10018496), LE Fisher (10018493), Laurence Burroughs (2230228), Dave Barrett (10018514), Amir M Ghaemmaghami (10018526), L Kämmerling (10018511), C Mbadugha (10018502), JC Luckett (10018499), Grazziela P Figueredo (10018520), S Elsheikh (10018517)   +15 more
core   +2 more sources

A first‐in‐human, randomized study of the safety, pharmacokinetics and pharmacodynamics of povetacicept, an enhanced dual BAFF/APRIL antagonist, in healthy adults

Clinical and Translational Science
Therapeutic agents targeting the tumor necrosis factor (TNF) superfamily cytokines B‐cell activating factor (BAFF, BLyS) and/or A PRoliferation Inducing Ligand (APRIL) have demonstrated clinical effectiveness in multiple autoimmune diseases, such as ...
Rupert Davies, Stanford L. Peng, Jason Lickliter, Kristi McLendon, Amanda Enstrom, Allison G. Chunyk, Lori Blanchfield, NingXin Wang, Tiffany Blair, Heather M. Thomas, Alina Smith, Stacey R. Dillon   +11 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Immune mechanisms of protection: can adjuvants rise to the challenge? [PDF]

, 2010
For many diseases vaccines are lacking or only partly effective. Research on protective immunity and adjuvants that generate vigorous immune responses may help generate effective vaccines against such ...
MacLeod Megan KL, Philippa Marrack, Amy S McKee, Marrack, P., Megan KL MacLeod, Marrack Philippa, Kappler, J.W., John W Kappler, MacLeod, M.K.L., Kappler John W, McKee, A.S., McKee Amy S   +11 more
core   +1 more source

Determinants of innate immune responses to mycobacteria [PDF]

, 2012
Includes bibliographical references.Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers.
Shey, Muki Shehu
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology

Nature Communications
Aggregated TDP-43 is a hallmark of frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and limbic-predominant age-related TDP-43 encephalopathy (LATE), and a common co-pathology in other neurodegenerative diseases.
Efthymia Vokali, Elodie Chevalier, Nicolas Dreyfus, Dorian Charmey, Tania Melly, Jacqueline Kocher, Monisha Ratnam, Andreia M. Serra, Thomas Jaquier, Christophe Delgado, Myriam Ravache, Carlo Scialò, Sara Cappelli, Heiko Kroth, Francesca Capotosti, Ruth Luthi-Carter, Tariq Afroz, Madiha Derouazi, Cristian C. Constantinescu, Harro Seelaar, Emanuele Buratti, Peter T. Nelson, Magdalini Polymenidou, Andrea Pfeifer, Marie Kosco-Vilbois, Tamara Seredenina   +25 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source