Results 11 to 20 of about 4,903,889 (243)

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

Cancer Cell, 2015
Suzanne L Topalian
exaly   +2 more sources

Gut Microbiota Variations between Henoch-Schonlein Purpura and Henoch-Schonlein Purpura Nephritis

Gastroenterology Research and Practice, 2022
Background. In China, little is known regarding the differences between children with Henoch-Schonlein purpura (HSP) and Henoch-Schonlein purpura nephritis (HSPN) concerning their gut microbiota. Methods.
Fang Zhou, Qimin Shao, Lihong Jia, Chunyan Cai   +3 more
doaj   +1 more source

Relationship of Para and Perirenal Fat and High-Density Lipoprotein and Its Function in Patients with Type 2 Diabetes Mellitus

International Journal of Endocrinology, 2021
Background. Para and perirenal fat is a fat pad surrounding the kidneys. Recent studies showed the association between para and perirenal fat and cardiovascular diseases including atherosclerosis and hypertension.
Jing Ke, Yan Wang, Simo Liu, Kun Li, YueChao Xu, Longyan Yang, Dong Zhao   +6 more
doaj   +1 more source

First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects

Clinical and Translational Science, 2021
ALPN‐101 (ICOSL vIgD‐Fc) is an Fc fusion protein of a human inducible T cell costimulatory ligand (ICOSL) variant immunoglobulin domain (vIgD) designed to inhibit the cluster of differentiation 28 (CD28) and inducible T cell costimulator (ICOS) pathways ...
Jing Yang, Jason D. Lickliter, Jan L. Hillson, Gary D. Means, Russell J. Sanderson, Kay Carley, Almudena Tercero, Kristi L. Manjarrez, Jennifer R. Wiley, Stanford L. Peng   +9 more
doaj   +1 more source

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update

Journal of Clinical Oncology, 2021
PURPOSE To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events (irAEs) in patients treated with immune checkpoint inhibitor (ICPi) therapy. METHODS A multidisciplinary panel of medical
B. Schneider, J. Naidoo, B. Santomasso, C. Lacchetti, S. Adkins, M. Anadkat, M. Atkins, Kelly J. Brassil, J. Caterino, I. Chau, M. Davies, M. Ernstoff, L. Fecher, M. Ghosh, I. Jaiyesimi, J. Mammen, A. Naing, L. Nastoupil, T. Phillips, Laura D. Porter, C. Reichner, Carole Seigel, Jung-Min Song, A. Spira, M. Suarez‐Almazor, U. Swami, John A Thompson, Praveen Vikas, Yinghong Wang, J. Weber, P. Funchain, Kathryn Bollin   +31 more
semanticscholar   +1 more source

Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains

Frontiers in Immunology, 2020
Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases.
Steven D. Levin, Lawrence S. Evans, Susan Bort, Erika Rickel, Katherine E. Lewis, Rebecca P. Wu, Joseph Hoover, Sean MacNeil, David La, Martin F. Wolfson, Mark W. Rixon, Stacey R. Dillon, Michael G. Kornacker, Ryan Swanson, Stanford L. Peng   +14 more
doaj   +1 more source

The impact of short-term confinement on human innate immunity

Scientific Reports, 2022
During space missions cosmonauts are exposed to a myriad of distinct stressors such as radiation, overloads, weightlessness, radiation, isolation in artificial environmental conditions, which causes changes in immune system.
S. A. Ponomarev, A. A. Sadova, M. P. Rykova, K. D. Orlova, D. D. Vlasova, S. M. Shulgina, E. N. Antropova, O. V. Kutko, N. S. Germanov, V. S. Galina, V. A. Shmarov   +10 more
doaj   +1 more source

The Immune Landscape of Cancer.

Immunity, 2018
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA.
V. Thorsson, David L. Gibbs, S. Brown, D. Wolf, Dante S. Bortone, Tai-Hsien Ou Yang, Eduard Porta-Pardo, G. Gao, Christopher L. Plaisier, James A. Eddy, E. Ziv, A. Culhane, Evan O. Paull, A. Sivakumar, A. Gentles, R. Malhotra, F. Farshidfar, A. Colaprico, J. Parker, Lisle E. Mose, N. S. Vo, Jianfang Liu, Yuexin Liu, J. Rader, Varsha Dhankani, Sheila M. Reynolds, R. Bowlby, A. Califano, A. Cherniack, D. Anastassiou, D. Bedognetti, A. Rao, Ken Chen, A. Krasnitz, Hai Hu, T. Malta, H. Noushmehr, C. Pedamallu, S. Bullman, A. Ojesina, Andrew Lamb, Wanding Zhou, Hui Shen, T. Choueiri, J. Weinstein, J. Guinney, J. Saltz, R. Holt, Charles E. Rabkin, Samantha J. Caesar-Johnson, John A. Demchok, Ina Felau, M. Kasapi, M. Ferguson, C. Hutter, H. Sofia, R. Tarnuzzer, Zhining Wang, Liming Yang, J. Zenklusen, J. Zhang, Sudha Chudamani, Jia Liu, Laxmi Lolla, R. Naresh, T. Pihl, Qiang Sun, Yunhu Wan, Ye Wu, Juok Cho, T. DeFreitas, S. Frazer, Nils Gehlenborg, G. Getz, David I Heiman, Jaegil Kim, M. Lawrence, Pei Lin, S. Meier, M. Noble, G. Saksena, Douglas Voet, Hailei Zhang, Brady Bernard, N. Chambwe, T. Knijnenburg, R. Kramer, Kalle Leinonen, Michael Miller, Sheila M. Reynolds, I. Shmulevich, V. Thorsson, Wei Zhang, Rehan Akbani, B. Broom, A. Hegde, Z. Ju, R. Kanchi, Anil Korkut, Jun Li, Han Liang, Shiyun Ling, Wenbin Liu, Yiling Lu, G. Mills, Kwok-shing Ng, Michael J. Ryan, Jing Wang, Jiexin Zhang, Adam Abeshouse, J. Armenia, D. Chakravarty, Walid K. Chatila, Ino de Bruijn, Jianjiong Gao, Benjamin E. Gross, Zachary J. Heins, Ritika Kundra, Konnor C. La, M. Ladanyi, Augustin Luna, Moriah G. Nissan, Angelica Ochoa, Sarah M. Phillips, Ed Reznik, F. Sánchez-Vega, C. Sander, N. Schultz, R. Sheridan, O. Sumer, Yichao Sun, B. Taylor, Jioajiao Wang, Hongxin Zhang, Pavana Anur, Myron Peto, P. Spellman, C. Benz, Joshua M. Stuart, Christopher K. Wong, C. Yau, N. Hayes, M. Wilkerson, Adrian Ally, Miruna Balasundaram, Denise Brooks, R. Carlsen, E. Chuah, Noreen Dhalla, R. Holt, Steven J. M. Jones, K. Kasaian, Darlene Lee, Yussanne Ma, M. Marra, Michael Mayo, Richard A. Moore, A. Mungall, K. Mungall, Gordon Robertson, S. Sadeghi, J. Schein, Payal Sipahimalani, Angela Tam, N. Thiessen, Kane Tse, Tina Wong, Ashton C. Berger, R. Beroukhim, C. Cibulskis, S. Gabriel, G. Ha, M. Meyerson, S. Schumacher, J. Shih, M. Kucherlapati, R. Kucherlapati, S. Baylin, Ludmila V. Danilova, Moiz Bootwalla, Phillip H. Lai, D. Maglinte, D. J. Van Den Berg, D. Weisenberger, T. Auman, S. Balu, T. Bodenheimer, C. Fan, K. Hoadley, A. Hoyle, S. Jefferys, Corbin D. Jones, S. Meng, P. Mieczkowski, Amy H. Perou, C. Perou, J. Roach, Yan Shi, J. Simons, Tara J. Skelly, Matthew G. Soloway, Donghui Tan, Umadevi Veluvolu, T. Hinoue, P. Laird, Michelle Bellair, K. Chang, K. Covington, C. Creighton, H. Dinh, H. Doddapaneni, L. Donehower, J. Drummond, R. Gibbs, R. Glenn, Walker Hale, Yi Han, Jianhong Hu, V. Korchina, Sandy Lee, L. Lewis, Wei Li, Xiuping Liu, M. Morgan, Donna Morton, D. Muzny, J. Santibanez, Margi Sheth, E. Shinbrot, Linghua Wang, Min Wang, D. Wheeler, Liu Xi, Fengmei Zhao, J. Hess, Elizabeth L. Appelbaum, Matthew H. Bailey, M. Cordes, L. Ding, C. Fronick, L. Fulton, R. Fulton, C. Kandoth, E. Mardis, M. McLellan, Christopher A. Miller, Heather K. Schmidt, R. Wilson, D. Crain, Erin E. Curley, J. Gardner, Kevin R Lau, D. Mallery, S. Morris, J. Paulauskis, R. Penny, C. Shelton, T. Shelton, M. Sherman, E. Thompson, P. Yena, Jay Bowen, J. Gastier-Foster, M. Gerken, K. Leraas, T. Lichtenberg, N. Ramirez, L. Wise, E. Zmuda, N. Corcoran, T. Costello, C. Hovens, A. Carvalho, Ana C. de Carvalho, J. Fregnani, A. Longatto-Filho, R. Reis, C. Scapulatempo-Neto, H. C. Silveira, D. O. Vidal, Andrew Burnette, J. Eschbacher, B. Hermes, Ardene Noss, Rosy Singh, Matthew L. Anderson, Patricia D. Castro, M. Ittmann, D. Huntsman, B. Kohl, X. Le, Richard A. Thorp, C. Andry, Elizabeth R. Duffy, V. Lyadov, O. Paklina, G. Setdikova, A. Shabunin, M. Tavobilov, C. McPherson, R. Warnick, R. Berkowitz, Daniel Cramer, C. Feltmate, N. Horowitz, A. Kibel, M. Muto, C. Raut, A. Malykh, J. Barnholtz-Sloan, Wendi Barrett, K. Devine, J. Fulop, Q. Ostrom, K. Shimmel, Yingli Wolinsky, A. Sloan, A. D. De Rose, F. Giuliante, M. Goodman, B. Karlan, C. Hagedorn, J. Eckman, Jodi Harr, J. Myers, Kelinda Tucker, L. A. Zach, B. Deyarmin, L. Kvecher, C. Larson, R. Mural, S. Somiari, A. Vícha, T. Zelinka, Joseph Bennett, M. Iacocca, B. Rabeno, P. Swanson, M. Latour, L. Lacombe, B. Têtu, A. Bergeron, Mary McGraw, S. Staugaitis, J. Chabot, H. Hibshoosh, A. Sepulveda, T. Su, Timothy C. Wang, O. Potapova, Olga Voronina, L. Desjardins, O. Mariani, S. Roman-Roman, X. Sastre, M. Stern, F. Cheng, S. Signoretti, A. Berchuck, D. Bigner, E. Lipp, J. Marks, S. McCall, R. McLendon, A. Secord, A. Sharp, M. Behera, D. Brat, Amy Y. Chen, K. Delman, S. Force, F. Khuri, K. Magliocca, S. Maithel, J. Olson, T. Owonikoko, A. Pickens, S. Ramalingam, Dong-Myung Shin, G. Sica, Erwin G. Van Meir, Hongzhen Zhang, Wil Eijckenboom, A. Gillis, E. Korpershoek, L. Looijenga, W. Oosterhuis, H. Stoop, K. V. van Kessel, E. Zwarthoff, C. Calatozzolo, L. Cuppini, S. Cuzzubbo, F. DiMeco, G. Finocchiaro, L. Mattei, A. Perin, B. Pollo, Chu Chen, J. Houck, Pawadee Lohavanichbutr, A. Hartmann, C. Stoehr, R. Stoehr, H. Taubert, S. Wach, B. Wullich, W. Kycler, D. Murawa, M. Wiznerowicz, K. Chung, J. Edenfield, Julie M Martin, E. Baudin, G. Bubley, R. Bueno, A. De Rienzo, W. Richards, S. Kalkanis, T. Mikkelsen, L. Scarpace, N. Girard, M. Aymerich, E. Campo, E. Giné, A. Guillermo, Nguyen Van Bang, Phan Thi Hong Hanh, Bui Duc Phu, Yufang Tang, H. Colman, K. Evason, P. Dottino, J. Martignetti, H. Gabra, H. Juhl, Teniola Akeredolu, Serghei Stepa, D. Hoon, K. Ahn, K. Kang, F. Beuschlein, A. Breggia, M. Birrer, D. Bell, M. Borad, A. Bryce, E. Castle, V. Chandan, J. Cheville, J. Copland, M. Farnell, T. Flotte, N. Giama, T. Ho, M. Kendrick, J. Kocher, Karla J. Kopp, C. Moser, D. Nagorney, D. O'Brien, B. O'neill, T. Patel, G. Petersen, F. Que, M. Rivera, L. Roberts, R. Smallridge, T. Smyrk, M. Stanton, H. Thompson, M. Torbenson, J. D. Yang, Lizhi Zhang, F. Brimo, J. Ajani, Ana Maria Angulo Gonzalez, C. Behrens, J. Bondaruk, R. Broaddus, B. Czerniak, B. Esmaeli, J. Fujimoto, J. Gershenwald, Charles C. Guo, C. Logothetis, F. Meric-Bernstam, C. Moran, L. Ramondetta, D. Rice, A. Sood, P. Tamboli, T. Thompson, P. Troncoso, A. Tsao, I. Wistuba, Candace D. Carter, L. Haydu, P. Hersey, V. Jakrot   +499 more
semanticscholar   +1 more source

Binding Affinity Measurement of Antibodies from Crude Hybridoma Samples by SPR

Bio-Protocol, 2014
Surface Plasmon Resonance (SPR) is widely used to generate kinetic and affinity information on specific interactions between biomolecules. This technique is label-free and monitors the binding event in real-time. It is generally used for characterization
Dorin Ndao, David Hickman, María López-Deber, Aurélien Davranche, Andrea Pfeifer, Andreas Muhs   +5 more
doaj   +1 more source

The Application of Evidence-Based Medicine in Individualized Medicine

Biomedicines, 2023
The fundamental aim of healthcare is to improve overall health of the population by providing state-of-the-art healthcare for individuals at an affordable cost. The foundation for this system is largely referred to as “evidence-based medicine”. Too often,
Peter Van de Vliet, Tobias Sprenger, Linde F. C. Kampers, Jennifer Makalowski, Volker Schirrmacher, Wilfried Stücker, Stefaan W. Van Gool   +6 more
doaj   +1 more source