Results 21 to 30 of about 2,500,076 (170)
Infectious Diseases and Therapy, 2023 Introduction AZD7442 (tixagevimab/cilgavimab) comprises neutralising monoclonal antibodies (mAbs) that bind to distinct non-overlapping epitopes on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. Viral evolution during mAb
Gustavo H. Kijak +15 more
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Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD
Acta Neuropathologica CommunicationsAbnormal cytoplasmic localization and accumulation of pathological transactive response DNA binding protein of 43 kDa (TDP-43) underlies several devastating diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ...
Elodie Chevalier +9 more
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Molecular Therapy: Oncolytics, 2016 We have engineered an integration-deficient lentiviral vector, LV305, to deliver the tumor antigen NY-ESO-1 to human dendritic cells in vivo through pseudotyping with a modified Sindbis virus envelop protein.
Tina Chang Albershardt +5 more
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Personal immunity versus social immunity [PDF]
Behavioral Ecology, 2010 It is well known that organisms defend their fitness against attack from parasites and pathogens by mounting a personal immune response. However, there is increasing evidence that organisms from diverse taxa also exhibit immune responses for the purpose of protecting other individuals as well as themselves.
Cotter, Sheena, Kilner, R.M.
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Immune Dysregulation in Immune Thrombocytopenia [PDF]
Seminars in Hematology, 2013 Immune thrombocytopenia (ITP) is a bleeding disorder characterized by low platelet counts due to decreased platelet production as well as increased platelet destruction by autoimmune mechanisms. A shift toward Th1 and possibly Th17 cells together with impaired regulatory compartment, including T-regulatory (Tregs) and B-regulatory (Bregs) cells, have ...
Karina, Yazdanbakhsh +2 more
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BMC Complementary Medicine and Therapies, 2022 Background Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes local bone erosion and systemic osteoporosis. Harpagoside (HAR), an iridoid glycoside, has various pharmacological effects on pain, arthritis, and inflammation.
Ju-Young Kim +6 more
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Archivum Immunologiae et Therapiae Experimentalis, 2017 Skin is the largest organ of the body with a complex network of multitude of cell types that perform plastic and dynamic cellular communication to maintain several vital processes such as inflammation, immune response including induction of tolerance and disease prevention, wound healing, and angiogenesis.
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Nature Communications, 2023 Nirsevimab is a monoclonal antibody that binds to the respiratory syncytial virus (RSV) fusion protein. During the Phase 2b (NCT02878330) and MELODY (NCT03979313) clinical trials, infants received one dose of nirsevimab or placebo before their first RSV ...
Bahar Ahani +20 more
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Heteroclitic Immunization Induces Tumor Immunity [PDF]
The Journal of Experimental Medicine, 1998 In tumor transplantation models in mice, cytotoxic T lymphocytes (CTLs) are typically the primary effector cells. CTLs recognize major histocompatibility complex (MHC) class I–associated peptides expressed by tumors, leading to tumor rejection. Peptides presented by cancer cells can originate from viral proteins, normal self-proteins regulated during ...
R, Dyall +9 more
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International Journal of Vascular MedicineConclusions: In summary, our findings suggest that the risk of PAD is positively correlated with the number of MetS components in patients with T2DM, especially among younger patients and older patients. Additionally, the positive association between the
Xiaotong Feng +7 more
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