Results 21 to 30 of about 4,903,889 (243)

Design of a titering assay for lentiviral vectors utilizing direct extraction of DNA from transduced cells in microtiter plates

Molecular Therapy: Methods & Clinical Development, 2016
Using lentiviral vector products in clinical applications requires an accurate method for measuring transduction titer. For vectors lacking a marker gene, quantitative polymerase chain reaction is used to evaluate the number of vector DNA copies in ...
Michele E Murphy, Chintan D Vin, Megan M Slough, Wayne R Gombotz, Brenna Kelley-Clarke   +4 more
doaj   +1 more source

Association between Sleep Duration and Left Ventricular Hypertrophy for Patients with Type 2 Diabetes Mellitus

International Journal of Endocrinology, 2023
Objective. In this study, we aimed to estimate the impact of sleep duration on left ventricular hypertrophy (LVH) in type 2 diabetes mellitus (T2DM). Methods.
Lin Mu, Chao Li, Wenying Zhao, Aihua Li, Dong Zhao, Baoyu Zhang   +5 more
doaj   +1 more source

Frequent adaptive immune responses against arginase-1

OncoImmunology, 2018
The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Evelina Martinenaite, Rasmus Erik Johansson Mortensen, Morten Hansen, Morten Orebo Holmström, Shamaila Munir Ahmad, Nicolai Grønne Dahlager Jørgensen, Özcan Met, Marco Donia, Inge Marie Svane, Mads Hald Andersen   +9 more
doaj   +1 more source

An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma

OncoImmunology, 2021
Cells in the tumor microenvironment of Follicular lymphoma (FL) express checkpoint molecules such as programmed death ligands 1 and 2 (PD-L1 and PD-L2) and are suppressing anti-tumor immune activity.
Uffe Klausen, Nicolai Grønne Dahlager Jørgensen, Jacob Handlos Grauslund, Shamaila Munir Ahmad, Anne Ortved Gang, Evelina Martinenaite, Stine Emilie Weis-Banke, Marie Fredslund Breinholt, Guy Wayne Novotny, Julie Westerlin Kjeldsen, Morten Orebo Holmström, Lone Bredo Pedersen, Christian Bjørn Poulsen, Per Boye Hansen, Özcan Met, Inge Marie Svane, Carsten Utoft Niemann, Lars Møller Pedersen, Mads Hald Andersen   +18 more
doaj   +1 more source

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Molecular Cancer, 2021
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME).
Xiaoqi Mao, Jin Xu, Wei Wang, Chen Liang, J. Hua, Jiang Liu, Bo Zhang, Qingcai Meng, Xianjun Yu, S. Shi   +9 more
semanticscholar   +1 more source

Coronavirus infections and immune responses

Journal of Medical Virology, 2020
Coronaviruses (CoVs) are by far the largest group of known positive‐sense RNA viruses having an extensive range of natural hosts. In the past few decades, newly evolved Coronaviruses have posed a global threat to public health.
Geng Li, Yaohua Fan, Yan-ni Lai, Tiantian Han, Zonghui Li, Peiwen Zhou, Pan Pan, Wenbiao Wang, Dingwen Hu, Xiaohong Liu, Qiwei Zhang, Jianguo Wu   +11 more
semanticscholar   +1 more source

PD-1 blockade induces responses by inhibiting adaptive immune resistance

Nature, 2014
Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durable clinical responses in patients with various cancer types.
P. Tumeh, C. Harview, J. Yearley, I. Shintaku, E. Taylor, L. Robert, B. Chmielowski, M. Spasić, G. Henry, V. Ciobanu, Alisha N. West, M. Carmona, Christine Kivork, E. Seja, Grace Cherry, Antonio Gutierrez, T. Grogan, C. Mateus, G. Tomasic, J. Glaspy, R. Emerson, H. Robins, R. Pierce, D. Elashoff, C. Robert, A. Ribas   +25 more
semanticscholar   +1 more source

Immune oncology, immune responsiveness and the theory of everything

Journal for ImmunoTherapy of Cancer, 2018
Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic and long lasting but occur in a subset of tumors and are largely dependent upon the pre-existing immune contexture of individual cancers.
Tolga Turan, Deepti Kannan, Maulik Patel, J. Matthew Barnes, Sonia G. Tanlimco, Rongze Lu, Kyle Halliwill, Sarah Kongpachith, Douglas E. Kline, Wouter Hendrickx, Alessandra Cesano, Lisa H. Butterfield, Howard L. Kaufman, Thomas J. Hudson, Davide Bedognetti, Francesco Marincola, Josue Samayoa   +16 more
doaj   +1 more source

Selection of Murine Lymphoid and Hematopoietic Cells Using Polystyrene Tissue Culture Devices Containing Covalently Immobilized Antibody

BioTechniques, 1996
We have established rapid procedures that negatively deplete and positively select for specific murine cell populations. By using polystyrene tissue culture flasks containing a covalently bound mouse anti-rat antibody and specific anti-mouse, cell ...
A.E. Berson, K.M. Knobel, D. Rood, K. Chen, D. Lamons, M.A. McNally, T.B. Okarma, J.S. Lebkowski   +7 more
doaj   +1 more source

Genetic evidence for causal effects of leukocyte counts on risk for rheumatoid arthritis

Scientific Reports, 2023
Rheumatoid arthritis (RA) is an autoimmune disease characterized by the accumulation of leukocytes and inflammatory mediators within the synovial tissue. Leukocyte counts are proposed to play a role in the pathogenesis of RA.
Jin-Mei You, Yao-Chen Zhang, Ke-Yi Fan, Shang-Kai Bai, Zi-Yu Zhang, He-Yi Zhang, Ting Cheng, Yue-Hong Huo, Cai-Hong Wang, Xiao-Feng Li, Sheng-Xiao Zhang   +10 more
doaj   +1 more source