Results 11 to 20 of about 5,479,910 (356)

Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework

mAbs, 2023
Optimal pharmacokinetic (PK) properties of therapeutic monoclonal antibodies (mAbs) are essential to achieve the desired pharmacological benefits in patients.
Romain Ollier, Aline Fuchs, Florence Gauye, Katarzyna Piorkowska, Sébastien Menant, Monisha Ratnam, Paolo Montanari, Florence Guilhot, Didier Phillipe, Mickael Audrain, Anne-Laure Egesipe, Damien Névoltris, Tamara Seredenina, Andrea Pfeifer, Marie Kosco-Vilbois, Tariq Afroz   +15 more
doaj   +1 more source

The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity

Nature Communications, 2022
CD28 costimulatory signalling can be suppressed by immune checkpoints, such as CTLA-4 and PD-1. Here the authors describe the design of the fusion therapeutic davoceticept (ALPN-202), based on a variant CD80 extracellular domain engineered to bind PD-L1 ...
Mark F. Maurer, Katherine E. Lewis, Joseph L. Kuijper, Dan Ardourel, Chelsea J. Gudgeon, Siddarth Chandrasekaran, Sherri L. Mudri, Kayla N. Kleist, Chris Navas, Martin F. Wolfson, Mark W. Rixon, Ryan Swanson, Stacey R. Dillon, Steven D. Levin, Yengo Raymond Kimbung, Masato Akutsu, Derek T. Logan, Björn Walse, Kristine M. Swiderek, Stanford L. Peng   +19 more
doaj   +1 more source

Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD

Neurobiology of Disease, 2023
Effective therapies are urgently needed to safely target TDP-43 pathology as it is closely associated with the onset and development of devastating diseases such as frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) and amyotrophic ...
Tariq Afroz, Elodie Chevalier, Mickael Audrain, Christopher Dumayne, Tamar Ziehm, Roger Moser, Anne-Laure Egesipe, Lorène Mottier, Monisha Ratnam, Manuela Neumann, Daniel Havas, Romain Ollier, Kasia Piorkowska, Mayank Chauhan, Alberto B. Silva, Samjhana Thapa, Jan Stöhr, Andrej Bavdek, Valerie Eligert, Oskar Adolfsson, Peter T. Nelson, Sílvia Porta, Virginia M.-Y. Lee, Andrea Pfeifer, Marie Kosco-Vilbois, Tamara Seredenina   +25 more
doaj   +1 more source

Gut Microbiota Variations between Henoch-Schonlein Purpura and Henoch-Schonlein Purpura Nephritis

Gastroenterology Research and Practice, 2022
Background. In China, little is known regarding the differences between children with Henoch-Schonlein purpura (HSP) and Henoch-Schonlein purpura nephritis (HSPN) concerning their gut microbiota. Methods.
Fang Zhou, Qimin Shao, Lihong Jia, Chunyan Cai   +3 more
doaj   +1 more source

Relationship of Para and Perirenal Fat and High-Density Lipoprotein and Its Function in Patients with Type 2 Diabetes Mellitus

International Journal of Endocrinology, 2021
Background. Para and perirenal fat is a fat pad surrounding the kidneys. Recent studies showed the association between para and perirenal fat and cardiovascular diseases including atherosclerosis and hypertension.
Jing Ke, Yan Wang, Simo Liu, Kun Li, YueChao Xu, Longyan Yang, Dong Zhao   +6 more
doaj   +1 more source

First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects

Clinical and Translational Science, 2021
ALPN‐101 (ICOSL vIgD‐Fc) is an Fc fusion protein of a human inducible T cell costimulatory ligand (ICOSL) variant immunoglobulin domain (vIgD) designed to inhibit the cluster of differentiation 28 (CD28) and inducible T cell costimulator (ICOS) pathways ...
Jing Yang, Jason D. Lickliter, Jan L. Hillson, Gary D. Means, Russell J. Sanderson, Kay Carley, Almudena Tercero, Kristi L. Manjarrez, Jennifer R. Wiley, Stanford L. Peng   +9 more
doaj   +1 more source

The impact of short-term confinement on human innate immunity

Scientific Reports, 2022
During space missions cosmonauts are exposed to a myriad of distinct stressors such as radiation, overloads, weightlessness, radiation, isolation in artificial environmental conditions, which causes changes in immune system.
S. A. Ponomarev, A. A. Sadova, M. P. Rykova, K. D. Orlova, D. D. Vlasova, S. M. Shulgina, E. N. Antropova, O. V. Kutko, N. S. Germanov, V. S. Galina, V. A. Shmarov   +10 more
doaj   +1 more source

Immune-system inspired approach for decentralized multi-agent control [PDF]

, 2016
This paper contains the first steps towards the development of a fully decentralized system framework. The novel approach that has been taken is derived from the inherent properties of the immune system. An assessment of the proposed control architecture
German, S., Shin, Hyo-Sang, Tsourdos, Antonios   +2 more
core   +1 more source

IMMUNITY [PDF]

International Economic Review, 2013
AbstractLegal provisions that protect elected politicians from prosecution have been common throughout history and still exist in most democracies. We provide the first systematic measurement of immunity and study, theoretically and empirically, its relation to corruption. Theory predicts that immunity is a double‐edged sword.
Karthik Reddy, Moritz Schularick, Vasiliki Skreta   +2 more
openaire   +6 more sources

Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains

Frontiers in Immunology, 2020
Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases.
Steven D. Levin, Lawrence S. Evans, Susan Bort, Erika Rickel, Katherine E. Lewis, Rebecca P. Wu, Joseph Hoover, Sean MacNeil, David La, Martin F. Wolfson, Mark W. Rixon, Stacey R. Dillon, Michael G. Kornacker, Ryan Swanson, Stanford L. Peng   +14 more
doaj   +1 more source