Results 51 to 60 of about 4,903,889 (243)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Modeling Alzheimer’s disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

Frontiers in Neuroscience, 2023
IntroductionPeople with DS are highly predisposed to Alzheimer’s disease (AD) and demonstrate very similar clinical and pathological features. Ts65Dn mice are widely used and serve as the best-characterized animal model of DS.MethodsWe undertook studies
Cassia Overk, Emma Fiorini, Chiara Babolin, Marija Vukicevic, Catherine Morici, Rime Madani, Valerie Eligert, Marie Kosco-Vilbois, Amanda Roberts, Ann Becker, Andrea Pfeifer, William C. Mobley   +11 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

STING an Endoplasmic Reticulum Adaptor that Facilitates Innate Immune Signaling

Nature, 2008
The cellular innate immune system is essential for recognizing pathogen infection and for establishing effective host defence. But critical molecular determinants responsible for facilitating an appropriate immune response—following infection with DNA ...
Hiroki Ishikawa, G. Barber
semanticscholar   +1 more source

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Science, 2020
Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al.
D. Mathew, Josephine R. Giles, A. Baxter, D. Oldridge, A. Greenplate, Jennifer E. Wu, Cécile Alanio, L. Kuri-Cervantes, M. Pampena, K. D’Andrea, Sasikanth Manne, Zeyu Chen, Y. J. Huang, J. Reilly, A. Weisman, C. Ittner, O. Kuthuru, J. Dougherty, Kito Nzingha, N. Han, Justin Y. Kim, A. Pattekar, E. Goodwin, E. M. Anderson, M. Weirick, S. Gouma, C. P. Arevalo, M. Bolton, Fang Chen, S. Lacey, H. Ramage, S. Cherry, S. Hensley, Sokratis A. Apostolidis, Alexander C. Huang, L. Vella, L. Vella, M. Betts, N. Meyer, E. Wherry   +39 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

U-Shaped Association of Visceral Fat Area With Diabetic Peripheral Neuropathy

Journal of Diabetes Research
Conclusions: A U-shaped association exists between VFA and DPN prevalence in T2DM patients, suggesting clinical relevance of moderate visceral adiposity.
Xianhua Li, Yingxiang Wang, Xiaotong Feng, Lin Mao, Jing Ke, Dong Zhao   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells

Frontiers in Immunology, 2019
The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation.
Elisabeth Zinser, Ronald Naumann, Andreas B. Wild, Julia Michalski, Andrea Deinzer, Lena Stich, Christine Kuhnt, Alexander Steinkasserer, Ilka Knippertz   +8 more
doaj   +1 more source