Results 1 to 10 of about 217,947 (308)

Immune‐dysregulation harnessing in myeloid neoplasms [PDF]

Cancer Medicine
Myeloid malignancies arise in bone marrow microenvironments and shape these microenvironments in favor of malignant development. Immune suppression is one of the most important stages in myeloid leukemia progression.
Mohammad Jafar Sharifi, Ling Xu, Nahid Nasiri, Mehnoosh Ashja‐Arvan, Hadis Soleimanzadeh, Mazdak Ganjalikhani‐Hakemi   +5 more
doaj   +4 more sources

Role of immune dysregulation in peri-implantitis [PDF]

Frontiers in Immunology
Peri-implantitis, a complex condition that can lead to dental implant failure, is characterized by inflammatory destruction resulting from immune dysregulation.
Mingshu Huang, Chao Wang, Ping Li, Ping Li, Hongye Lu, An Li, Shulan Xu   +6 more
doaj   +2 more sources

Multidisciplinary approach to treating complex immune dysregulation disorders: an adaptive model for institutional implementation [PDF]

Frontiers in Immunology
Patients with immune dysregulation may present with varying combinations of autoimmunity, autoinflammation, immunodeficiency, atopy, lymphoproliferation, and/or malignancy, often with multisystem involvement.
Lauren A. Henderson, Roshini S. Abraham, Aisha Ahmed, Lindsey Blount, Scott W. Canna, Natalia S. Chaimowitz, Shanmuganathan Chandrakasan, Bria Coates, James A. Connelly, Megan A. Cooper, Christine N. Duncan, Anthony French, Melissa Hazen, Michelle L. Hermiston, Brian Nolan, Anish Ray, Melissa J. Rose, Lisa Forbes Satter, Lisa Forbes Satter, Grant Schulert, Sara Kristen Sexson Tejtel, Tiphanie Vogel, Tiphanie Vogel, Kelly Walkovich, Matt S. Zinter, Edward M. Behrens   +25 more
doaj   +2 more sources

Down Syndrome in Children: A Primary Immunodeficiency with Immune Dysregulation [PDF]

Children
Background: The multisystemic features of Down syndrome (DS) in children are accompanied by immunodeficiency, making them susceptible to infections and immune dysregulation with autoimmune, allergic, inflammatory, and hematological complications.
Aleksandra Szczawińska-Popłonyk, Natalia Popłonyk, Karina Awdi   +2 more
doaj   +2 more sources

Autoimmunity and Inborn Errors of Immunity: Two Faces of the Same Coin! [PDF]

Pediatric Infectious Disease, 2022
Autoimmune disorders are a heterogeneous group of disorders characterized by immune dysregulation and are associated with a loss of tolerance to self-antigens.
Neha Singh, Sagar Bhattad
doaj   +1 more source

Systemic Immune Dysregulation Correlates With Clinical Features of Early Non-Small Cell Lung Cancer

Frontiers in Immunology, 2022
BackgroundSystemic immune dysregulation correlates with cancer progression. However, the clinical implications of systemic immune dysregulation in early non-small cell lung cancer (NSCLC) remain unclear.MethodsUsing a panel of 9 markers to identify 12 ...
Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Feng Du, Zhongwei Xin, Zhongwei Xin, Dang Wu, Dang Wu, Qun Yu, Yimin Wu, Zhouyu Zhu, Wenshan Li, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Ying Chai, Shenghang Jin, Shenghang Jin, Pin Wu, Pin Wu   +21 more
doaj   +1 more source

The yin-yang of immunity: Immune dysregulation in myelodysplastic syndrome with different risk stratification

Frontiers in Immunology, 2022
Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid clonal diseases with diverse clinical courses, and immune dysregulation plays an important role in the pathogenesis of MDS.
Xiaohuan Peng, Xiaohuan Peng, Xiaofeng Zhu, Xiaofeng Zhu, Tianning Di, Tianning Di, Futian Tang, Xiaojia Guo, Yang Liu, Jun Bai, Yanhong Li, Lijuan Li, Lijuan Li, Liansheng Zhang, Liansheng Zhang   +14 more
doaj   +1 more source

Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction

Nature Communications, 2021
Multi-inflammatory syndrome in children (MIS-C) can be associated with SARS-CoV-2 infection but can also be similar to other inflammatory syndromes. Here the authors characterise the plasma proteome phenotype in MIS-C and compare to other SARS-CoV-2 ...
Caroline Diorio, Rawan Shraim, Laura A. Vella, Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Scott W. Canna, Sarah E. Henrickson, Kevin O. McNerney, Frances Balamuth, Chakkapong Burudpakdee, Jessica Lee, Tomas Leng, Alvin Farrel, Michele P. Lambert, Kathleen E. Sullivan, E. John Wherry, David T. Teachey, Hamid Bassiri, Edward M. Behrens   +19 more
doaj   +1 more source

Immune Dysregulation in IgG4-Related Disease

Frontiers in Immunology, 2021
Immunoglobin G4-related disease (IgG4-RD) is one of the newly discovered autoimmune diseases characterized by elevated serum IgG4 concentrations and multi-organ fibrosis.
Jiachen Liu, Wei Yin, Lisa S. Westerberg, Pamela Lee, Quan Gong, Yan Chen, Lingli Dong, Chaohong Liu   +7 more
doaj   +1 more source

Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical implications

Frontiers in Immunology, 2023
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis (Option B+) has dramatically improved the health of HIV-infected women and their children, with the majority being of HIV-exposed children born uninfected (HEU).
Hope Mataramvura, Madeleine J. Bunders, Madeleine J. Bunders, Kerina Duri   +3 more
doaj   +1 more source