Immune dysregulation in myelodysplastic syndrome [PDF]
Hematology Reports, 2010 Myelodysplastic syndrome (MDS) represents one of the most challenging health-related problems in the elderly. Characterized by dysplastic morphology in the bone marrow in association with ineffective hematopoiesis, pathophysiological causes of this ...
Chiharu Sugimori +2 more
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Role of immune dysregulation in peri-implantitis [PDF]
Frontiers in ImmunologyPeri-implantitis, a complex condition that can lead to dental implant failure, is characterized by inflammatory destruction resulting from immune dysregulation.
Mingshu Huang +6 more
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Immune‐dysregulation harnessing in myeloid neoplasms [PDF]
Cancer MedicineMyeloid malignancies arise in bone marrow microenvironments and shape these microenvironments in favor of malignant development. Immune suppression is one of the most important stages in myeloid leukemia progression.
Mohammad Jafar Sharifi +5 more
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Mechanism-Based Strategies for the Management of Autoimmunity and Immune Dysregulation in Primary Immunodeficiencies [PDF]
, 2016 A broad spectrum of autoimmunity is now well described in patients with primary immunodeficiencies (PIDs). Management of autoimmune disease in the background of PID is particularly challenging given the seemingly discordant goals of immune support and ...
Jolán E. Walter +4 more
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Multidisciplinary approach to treating complex immune dysregulation disorders: an adaptive model for institutional implementation [PDF]
Frontiers in ImmunologyPatients with immune dysregulation may present with varying combinations of autoimmunity, autoinflammation, immunodeficiency, atopy, lymphoproliferation, and/or malignancy, often with multisystem involvement.
Lauren A. Henderson +25 more
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Immune Dysregulation as a Cause of Autoinflammation in Fragile X Premutation Carriers: Link between FMRI CGG Repeat Number and Decreased Cytokine Responses [PDF]
, 2014 BackgroundIncreased rates of autoinflammatory and autoimmune disorders have been observed in female premutation carriers of CGG repeat expansion alleles of between 55-200 repeats in the fragile X mental retardation 1 (FMR1) gene.
Milo Careaga +5 more
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Down Syndrome in Children: A Primary Immunodeficiency with Immune Dysregulation [PDF]
ChildrenBackground: The multisystemic features of Down syndrome (DS) in children are accompanied by immunodeficiency, making them susceptible to infections and immune dysregulation with autoimmune, allergic, inflammatory, and hematological complications.
Aleksandra Szczawińska-Popłonyk +2 more
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Therapeutic strategies focusing on immune dysregulation and neuroinflammation in rosacea [PDF]
Frontiers in ImmunologyRosacea is a complex inflammatory condition characterized by papulopustular lesions and erythema on the central face for which there is no cure.
Kuan-Yi Tu +5 more
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The impact of immune dysregulation on the risk of malignancy in common variable immunodeficiency: insights from a multicenter study. [PDF]
Front ImmunolBackground: Common Variable Immunodeficiency (CVID) represents a heterogenic group of primary immunodeficiencies (PID) characterized by impaired antibody production and susceptibility to infections.
Cabañero-Navalon MD +23 more
europepmc +2 more sources
Autoimmunity and Inborn Errors of Immunity: Two Faces of the Same Coin! [PDF]
Pediatric Infectious Disease, 2022 Autoimmune disorders are a heterogeneous group of disorders characterized by immune dysregulation and are associated with a loss of tolerance to self-antigens.
Neha Singh, Sagar Bhattad
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