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Autoimmunity and Inborn Errors of Immunity: Two Faces of the Same Coin! [PDF]

Pediatric Infectious Disease, 2022
Autoimmune disorders are a heterogeneous group of disorders characterized by immune dysregulation and are associated with a loss of tolerance to self-antigens.
Neha Singh, Sagar Bhattad
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Systemic Immune Dysregulation Correlates With Clinical Features of Early Non-Small Cell Lung Cancer

Frontiers in Immunology, 2022
BackgroundSystemic immune dysregulation correlates with cancer progression. However, the clinical implications of systemic immune dysregulation in early non-small cell lung cancer (NSCLC) remain unclear.MethodsUsing a panel of 9 markers to identify 12 ...
Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Feng Du, Zhongwei Xin, Zhongwei Xin, Dang Wu, Dang Wu, Qun Yu, Yimin Wu, Zhouyu Zhu, Wenshan Li, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Ying Chai, Shenghang Jin, Shenghang Jin, Pin Wu, Pin Wu   +21 more
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The yin-yang of immunity: Immune dysregulation in myelodysplastic syndrome with different risk stratification

Frontiers in Immunology, 2022
Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid clonal diseases with diverse clinical courses, and immune dysregulation plays an important role in the pathogenesis of MDS.
Xiaohuan Peng, Xiaohuan Peng, Xiaofeng Zhu, Xiaofeng Zhu, Tianning Di, Tianning Di, Futian Tang, Xiaojia Guo, Yang Liu, Jun Bai, Yanhong Li, Lijuan Li, Lijuan Li, Liansheng Zhang, Liansheng Zhang   +14 more
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Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction

Nature Communications, 2021
Multi-inflammatory syndrome in children (MIS-C) can be associated with SARS-CoV-2 infection but can also be similar to other inflammatory syndromes. Here the authors characterise the plasma proteome phenotype in MIS-C and compare to other SARS-CoV-2 ...
Caroline Diorio, Rawan Shraim, Laura A. Vella, Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Scott W. Canna, Sarah E. Henrickson, Kevin O. McNerney, Frances Balamuth, Chakkapong Burudpakdee, Jessica Lee, Tomas Leng, Alvin Farrel, Michele P. Lambert, Kathleen E. Sullivan, E. John Wherry, David T. Teachey, Hamid Bassiri, Edward M. Behrens   +19 more
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Immune Dysregulation in IgG4-Related Disease

Frontiers in Immunology, 2021
Immunoglobin G4-related disease (IgG4-RD) is one of the newly discovered autoimmune diseases characterized by elevated serum IgG4 concentrations and multi-organ fibrosis.
Jiachen Liu, Wei Yin, Lisa S. Westerberg, Pamela Lee, Quan Gong, Yan Chen, Lingli Dong, Chaohong Liu   +7 more
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Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical implications

Frontiers in Immunology, 2023
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis (Option B+) has dramatically improved the health of HIV-infected women and their children, with the majority being of HIV-exposed children born uninfected (HEU).
Hope Mataramvura, Madeleine J. Bunders, Madeleine J. Bunders, Kerina Duri   +3 more
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Immune Dysregulation in Acute SARS-CoV-2 Infection

Pathogens and Immunity, 2023
Introduction: Neutralizing antibodies have been shown to develop rapidly following SARS-CoV-2 infection, specifically against spike (S) protein, where cytokine release and production is understood to drive the humoral immune response during acute ...
Lauren Grimm, Chinyere Onyeukwu, Grace Kenny, Danielle Parent, Jia Fu, Shaurya Dhingra, Emily Yang, James Moy, PJ Utz, Russell Tracy, Alan Landay   +10 more
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Novel Discoveries in Immune Dysregulation in Inborn Errors of Immunity

Frontiers in Immunology, 2021
With the expansion of our knowledge on inborn errors of immunity (IEI), it gradually becomes clear that immune dysregulation plays an important part.
Anwen Ren, Wei Yin, Heather Miller, Lisa S. Westerberg, Fabio Candotti, Chan-Sik Park, Pamela Lee, Quan Gong, Quan Gong, Yan Chen, Chaohong Liu   +10 more
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Immune Dysregulation in Pediatric Common Variable Immunodeficiency: Implications for the Diagnostic Approach

Frontiers in Pediatrics, 2022
Infections and infectious complications are hallmarks of common variable immunodeficiency (CVID) and the leading cause of morbidity and mortality in affected patients at any age.
Aleksandra Szczawińska-Popłonyk, Katarzyna Ta̧polska-Jóźwiak, Eyal Schwartzmann, Natalia Popłonyk   +3 more
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EPIGENETIC ALTERATIONS IN GENE EXPRESSION IN THE AGING IMMUNE SYSTEM

Anti-Aging Eastern Europe, 2023
Immunosenescence or aging of the immune system is characterized by dysregulation of the innate and adaptive immune system mechanisms, associated with a systemic low-grade inflammation (i.e., «inflammaging»), non-effective protective humoral and cellular ...
Dimitrina Miteva, Tsvetelina Velikova
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